ANTICANCER ACTIVITIES OF EVEN NUMBERED MONOKETO EICOSANOIC ACID ANILIDES AND SEMICARBAZONES

Abstract

This study was undertaken to examine the possible cytotoxic effect of anilide and semicarbazone derivatives of (4-12) monoketo eicosanoic acids (3.125 – 100 µM) on canine mammary tumour cell line (CMT-U27) as compared with doxorubicin. Among these compounds, 8-semicarbazone eicosanoic acid (3) and 10-keto eicosanoic acid anilide (9) displayed effective cytotoxic potential against CMT-U27 and IC₅₀ concentrations were recorded at 1.952 µM and 54.00 µM, respectively. 

Keywords

• Anilide,Semicarbazone,Fatty Acid,Canine mammary tumor

References

1. 1. Venkatesh P. Synthesis, characterization and antimicrobial activity of various schiff bases complexes of Zn(II) and Cu(II) ions. Asian J Pharm. Hea. Sci. 2011; 1: 8-11.
2. 2. Hussein MA, Omar RH, Farghaly HS. Design, synthesis, structure elucidation and biochemical evaluation of some schiff’s base derivatives bearing pyrazolo [3,4-D] pyrimidine-4-ones. Int. J. Acad Res. 2011; 3/2: 454-462.
3. 3. Nair R, Shah A, Baluja S, Chanda S. Synthesis and antibacterial activity of some schiff base complexes. J. Serb. Chem. Soc. 2006; 71: 733-44.
4. 4. Sathe BS, Jaychandran E, Jagtap VA, Sreenivasa GM. Synthesis characterization and anti-inflammatory evaluation of new fluorobenzothiazole schiff’s bases. Int. J. Pharm. Res. Dev. 2011; 3: 164-69.
5. 5. Pandey A, Dewangan D, Verma S, Mishra A, Dubey RD. Synthesis of schiff bases of 2-amino-5-aryl-1, 3, 4-thiadiazole and its analgesic, antiinflammatory, antibacterial and antitubercular activity. Int. J. Chem. Tech. Res. 2011; 3: 178-84.
6. 6. Fahmy HH, El-Eraky W, (2001) Synthesis and evaluation of analgesic and anti-inflammatory activities of O- substituted salicylamides. Arch. Pharm. Res. 24, 171-179.
7. 7. Chinnasamy RP, Sundararagan R, Govindaraj S, (2010) Synthesis, characterization and analgesic activity of novel Schiff base isatin derivatives. J. Adv. Pharm. Technol. Res. 1, 342-347.
8. 8. Ali MM, Jesmin M, Salam SMA, Khanam JA, Islam MF, Islam MN, (2009) Pesticidal activities of some schiff bases derived from benzoin, salicylaldehde, aminophenol and 2, 4- dinitrophenylhydrazine. J. Sci. Res. 1, 641-646.

9. 9. Jesmin M, Ali MM, Islam MN, (2008) Pesticidal Activity of some Schiff Base Complexes Derived from some Divalent Metal Acetates, Glycine and Salicylaldehyde. J. Sci. Found. 6, 49-56.
10. 10. Jon JK, Swieczkowski DM, Anthony JC, Truant JP, (1972) Fatty Acids and Derivatives as Antimicrobial Agents. Antimicrob. Agents Chemother. 2/1, 23-28.
11. 11. Maag H, (1984) Fatty acid derivatives: Important surfactants for household, cosmetic and industrial purposes. J. Am. Oil Chem. Soc. 61, 259-267.
12. 12. Pasha MA, Nanjundaswamy HM, (2004) Reductive fission of azoarenes to aminoarenes by aluminium/hydrazine hydrate. J. Chem. Res. 750-752.
13. 13. Hartley D, Kidd H, (1987) The Agrochemicals Hand Book, 2nd ed.; Royal Society of Chemistry: Nottingham, p 215.
14. 14. Maurer EW, Smith FD, (1980) Fatty acid amides and anilides, syntheses and antimicrobial properties. J. Am. Oil Chem. Soc. 57, 98-103.
15. 15. Shaikh MMA, Azad MAK, Jesmin M, Ahsan S, Rahman MM, Kraham JA, Islam MN, Shahria SMS, (2012) In vivo anticancer activity of vanillin semicarbazone. Asian Pac. J. Trop. Biomed. 438-442.
16. 16. Çelik H, Özeriş S, (1996) Synthesis of Even Numbered of (2-12) Monohydroxy Eicosanoic Acid Isomers. Chim. Acta Turc. 24, 23-27.