Year 2016, Volume 3 , Issue 2, Pages 147 - 158 2016-05-31

IN SILICO MODELLING OF CYTOTOXIC BEHAVIOUR OF ANTI-LEUKEMIC COMPOUNDS ON HL-60 CELL LINE

David Ebuka Arthur [1] , Adamu Uzairu [2] , Paul Mamza [3] , Eyije Abechi [4] , Gideon Shallangwa [5]


This research employs multiple linear regression technique in the modelling of some potent anti-leukemic compounds using paDEL molecular descriptor software calculator, to identify the best relationship between the chemical structure and toxicities of the anticancer datasets against some leukemic cell lines (HL-60). Statistical parameters such as Q2 and R2pred (test set) were computed to validate the strength of the model, while Williams plot was used to assess its applicability domain. The mean effects of the molecular descriptors in the models were calculated to illuminate the principal properties of the molecules responsible for their cytotoxicity.

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Journal Section Articles
Authors

Author: David Ebuka Arthur

Author: Adamu Uzairu

Author: Paul Mamza

Author: Eyije Abechi

Author: Gideon Shallangwa

Dates

Application Date : April 1, 2016
Acceptance Date : October 22, 2019
Publication Date : May 31, 2016

Bibtex @ { jotcsa260522, journal = {Journal of the Turkish Chemical Society Section A: Chemistry}, issn = {}, eissn = {2149-0120}, address = {}, publisher = {Turkish Chemical Society}, year = {2016}, volume = {3}, pages = {147 - 158}, doi = {10.18596/jotcsa.40785}, title = {IN SILICO MODELLING OF CYTOTOXIC BEHAVIOUR OF ANTI-LEUKEMIC COMPOUNDS ON HL-60 CELL LINE}, key = {cite}, author = {Arthur, David Ebuka and Uzairu, Adamu and Mamza, Paul and Abechi, Eyije and Shallangwa, Gideon} }
APA Arthur, D , Uzairu, A , Mamza, P , Abechi, E , Shallangwa, G . (2016). IN SILICO MODELLING OF CYTOTOXIC BEHAVIOUR OF ANTI-LEUKEMIC COMPOUNDS ON HL-60 CELL LINE. Journal of the Turkish Chemical Society Section A: Chemistry , 3 (2) , 147-158 . DOI: 10.18596/jotcsa.40785
MLA Arthur, D , Uzairu, A , Mamza, P , Abechi, E , Shallangwa, G . "IN SILICO MODELLING OF CYTOTOXIC BEHAVIOUR OF ANTI-LEUKEMIC COMPOUNDS ON HL-60 CELL LINE". Journal of the Turkish Chemical Society Section A: Chemistry 3 (2016 ): 147-158 <https://dergipark.org.tr/en/pub/jotcsa/issue/24619/260522>
Chicago Arthur, D , Uzairu, A , Mamza, P , Abechi, E , Shallangwa, G . "IN SILICO MODELLING OF CYTOTOXIC BEHAVIOUR OF ANTI-LEUKEMIC COMPOUNDS ON HL-60 CELL LINE". Journal of the Turkish Chemical Society Section A: Chemistry 3 (2016 ): 147-158
RIS TY - JOUR T1 - IN SILICO MODELLING OF CYTOTOXIC BEHAVIOUR OF ANTI-LEUKEMIC COMPOUNDS ON HL-60 CELL LINE AU - David Ebuka Arthur , Adamu Uzairu , Paul Mamza , Eyije Abechi , Gideon Shallangwa Y1 - 2016 PY - 2016 N1 - doi: 10.18596/jotcsa.40785 DO - 10.18596/jotcsa.40785 T2 - Journal of the Turkish Chemical Society Section A: Chemistry JF - Journal JO - JOR SP - 147 EP - 158 VL - 3 IS - 2 SN - -2149-0120 M3 - doi: 10.18596/jotcsa.40785 UR - https://doi.org/10.18596/jotcsa.40785 Y2 - 2019 ER -
EndNote %0 Journal of the Turkish Chemical Society Section A: Chemistry IN SILICO MODELLING OF CYTOTOXIC BEHAVIOUR OF ANTI-LEUKEMIC COMPOUNDS ON HL-60 CELL LINE %A David Ebuka Arthur , Adamu Uzairu , Paul Mamza , Eyije Abechi , Gideon Shallangwa %T IN SILICO MODELLING OF CYTOTOXIC BEHAVIOUR OF ANTI-LEUKEMIC COMPOUNDS ON HL-60 CELL LINE %D 2016 %J Journal of the Turkish Chemical Society Section A: Chemistry %P -2149-0120 %V 3 %N 2 %R doi: 10.18596/jotcsa.40785 %U 10.18596/jotcsa.40785
ISNAD Arthur, David Ebuka , Uzairu, Adamu , Mamza, Paul , Abechi, Eyije , Shallangwa, Gideon . "IN SILICO MODELLING OF CYTOTOXIC BEHAVIOUR OF ANTI-LEUKEMIC COMPOUNDS ON HL-60 CELL LINE". Journal of the Turkish Chemical Society Section A: Chemistry 3 / 2 (May 2016): 147-158 . https://doi.org/10.18596/jotcsa.40785
AMA Arthur D , Uzairu A , Mamza P , Abechi E , Shallangwa G . IN SILICO MODELLING OF CYTOTOXIC BEHAVIOUR OF ANTI-LEUKEMIC COMPOUNDS ON HL-60 CELL LINE. JOTCSA. 2016; 3(2): 147-158.
Vancouver Arthur D , Uzairu A , Mamza P , Abechi E , Shallangwa G . IN SILICO MODELLING OF CYTOTOXIC BEHAVIOUR OF ANTI-LEUKEMIC COMPOUNDS ON HL-60 CELL LINE. Journal of the Turkish Chemical Society Section A: Chemistry. 2016; 3(2): 158-147.