EASY SYNTHESIS OF 3,4-DIHYDROPYRIMIDIN -2-(1H)-ONES USING PHOSPHATE FERTILIZERS MAP, DAP AND TSP AS EFFICIENT CATALYSTS

Year 2017, Volume: 4 Issue: 2, 481 - 488, 06.03.2017

Sarra Sıbous Said Boukhrıs , Rachida Ghaılane Nouzha Habbadı Amina Hassıkou Abdelaziz Souızı

https://doi.org/10.18596/jotcsa.286900

Cited By: 4

Abstract

A simple,
efficient and green procedure has been developed for the synthesis of
dihydropyrimidinones (Products of Biginelli) using phosphate fertilizers (mono-ammonium
phosphate (MAP), di-ammonium phosphate (DAP) and triple super phosphate (TSP))
as catalyst. The one-step reaction involved the three compounds, which are
registered aromatic aldehydes, dicarbonyl compounds and the urea/thiourea. This
new method provides some advantages such as obtaining excellent yields (98%),
as well as the short duration of the reaction, which may attain 2 min. These
catalytic heterogeneous systems present also the advantage of being easily
recycled.

Keywords

Heterogeneous catalysts, MAP, DAP, TSP, 3, 4-dihydropyrimidin-2(1H)-ones

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