Year 2016, Volume 3 , Issue 3, Pages 47 - 58 2017-01-08

Production and Investigation of Controlled Drug Release Properties of Tamoxifen Loaded Alginate-Gum Arabic Microbeads

Rukiye Yavaşer [1] , Onur Korkmaz [2] , Bernis Girgin [3] , Çağdaş Sunna [4] , Arife Alev Karagözler [5]

The entrapment of tamoxifen onto alginate-gum arabic beads and the production of controlled drug release was investigated in this study. The polymeric system that would provide the controlled release of tamoxifen was formed using alginate and gum arabic. In the first phase of the study, the optimization of the alginate-gum arabic beads production was conducted; then the study continued with drug entrapment experiments. Tamoxifen entrapment yield was found to be approximately 90% of initial tamoxifen concentration. In vitro drug release experiments were performed in simulated gastric juice and intestinal fluid where the tamoxifen release was 20% and 53% of the initial drug present, respectively. As a result of this study, it is expected that a valuable contribution to the field of controlled drug release system production is realized.

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Journal Section Articles

Author: Rukiye Yavaşer

Author: Onur Korkmaz

Author: Bernis Girgin

Author: Çağdaş Sunna

Author: Arife Alev Karagözler


Application Date : July 4, 2016
Acceptance Date : February 25, 2020
Publication Date : January 8, 2017

Vancouver Yavaşer R , Korkmaz O , Girgin B , Sunna Ç , Karagözler A . Production and Investigation of Controlled Drug Release Properties of Tamoxifen Loaded Alginate-Gum Arabic Microbeads. Journal of the Turkish Chemical Society Section A: Chemistry. 2017; 58-47.