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Characterization of Magnetic Polymeric Microparticles

Year 2016, Volume: 3 Issue: 3, 185 - 204, 08.01.2017
https://doi.org/10.18596/jotcsa.74979

Abstract

The separation process is very important in a variety of scientific fields, especially in biochemistry and biotechnology. The separation performance of a method can be determined by the separation time and the purity of the separated molecule, which is directly proportional with the ligand chosen for the target molecule. The separation time is actually a very important step for the cost and the time-dependent analysis, especially in medical applications. Magnetic separation is a very advantageous technique because it eliminates the time-consuming sample preparation and centrifugation steps. However, the magnetic performance of adsorbent may not be strong enough to respond the magnetic force applied externally. Therefore, in nanoparticle studies, magnetic performance of nanoparticles is highly important. In this study, the magnetic performance of polymeric microparticles synthesized using different magnetic cores (Fe2O3&Fe3O4, Fe&Ni, Ni&Co, Fe&Ni&Co) with a solid support, HEMA (2-hydroxyl ethylmethacrylate), and a functional monomer, AdeM (adenine methacrylate), were compared. Some other properties such as size, zeta potential, surface morphology, etc. were also studied.

References

  • Josephson L, Tung C-H, Moore A, Weissleder R. High-efficiency intracellular magnetic labeling with novel superparamagnetic-Tat peptide conjugates. Bioconjugate chemistry. 1999;10(2):186-91.
  • Partington KM, Jenkinson EJ, Anderson G. A novel method of cell separation based on dual parameter immunomagnetic cell selection. Journal of immunological methods. 1999;223(2):195-205.
  • Türkmen D, Yavuz H, Denizli A. Synthesis of tentacle type magnetic beads as immobilized metal chelate affinity support for cytochrome c adsorption. International journal of biological macromolecules. 2006;38(2):126-33.
  • Park J-H, Im K-H, Lee S-H, Kim D-H, Lee D-Y, Lee Y-K, et al. Preparation and characterization of magnetic chitosan particles for hyperthermia application. Journal of Magnetism and Magnetic Materials. 2005;293(1):328-33.
  • Lübbe AS, Alexiou C, Bergemann C. Clinical applications of magnetic drug targeting. Journal of Surgical Research. 2001;95(2):200-6.
  • Hinds KA, Hill JM, Shapiro EM, Laukkanen MO, Silva AC, Combs CA, et al. Highly efficient endosomal labeling of progenitor and stem cells with large magnetic particles allows magnetic resonance imaging of single cells. Blood. 2003;102(3):867-72.
  • Mornet S, Vasseur S, Grasset F, Duguet E. Magnetic nanoparticle design for medical diagnosis and therapy. Journal of Materials Chemistry. 2004;14(14):2161-75.
  • Serda RE, Adolphi NL, Bisoffi M, Sillerud LO. Targeting and cellular trafficking of magnetic nanoparticles for prostate cancer imaging. Molecular imaging. 2007;6(4):277.
  • Ranzoni A, Sabatte G, van IJzendoorn LJ, Prins MW. One-step homogeneous magnetic nanoparticle immunoassay for biomarker detection directly in blood plasma. Acs Nano. 2012;6(4):3134-41.
  • Fee CJ. Stability of the liquid‐fluidized magnetically stabilized fluidized bed. AIChE journal. 1996;42(5):1213-9.
  • Graves D. Bioseparations in the Magnetically Stabilized Fluidized Bed, Chapter 9, 187 207 Barker and Ganetsos, Eds., Preparative and Production Scale Chromatography. Marcel Dekker, Inc., NY; 1993.
  • Sawakami-Kobayashi K, Segawa O, Obata K, Hornes E, Yohda M, Tajima H, et al. Multipurpose robot for automated cycle sequencing. Biotechniques. 2003;34(3):634-7.
  • Tanaka T, Matsunaga T. Fully automated chemiluminescence immunoassay of insulin using antibody-protein A-bacterial magnetic particle complexes. Analytical chemistry. 2000;72(15):3518-22.
  • Idil N, Perçin I, Karakoç V, Yavuz H, Aksöz N, Denizli A. Concanavalin A immobilized magnetic poly (glycidyl methacrylate) beads for prostate specific antigen binding. Colloids and Surfaces B: Biointerfaces. 2015;134:461-8.
  • Zheng W, Gao F, Gu H. Carboxylated magnetic polymer nanolatexes: preparation, characterization and biomedical applications. Journal of magnetism and magnetic materials. 2005;293(1):199-205.
  • Pollert E, Knížek K, Maryško M, Závěta K, Lančok A, Boháček J, et al. Magnetic poly (glycidyl methacrylate) microspheres containing maghemite prepared by emulsion polymerization. Journal of magnetism and magnetic materials. 2006;306(2):241-7.
  • Lea T, Vartdal F, Davies C, Ugelstad J. Magnetic monosized polymer particles for fast and specific fractionation of human mononuclear cells. Scandinavian journal of immunology. 1985;22(2):207-16.
  • Ramanujan R, Chong W. The synthesis and characterization of polymer coated iron oxide microspheres. Journal of Materials Science: Materials in Medicine. 2004;15(8):901-8.
  • Jayachandran KNN, Chatterji PR. Preparation of linear and crosslinked polymer microspheres by dispersion polymerization. Journal of Macromolecular Science, Part C: Polymer Reviews. 2001;41(1-2):79-94.
  • Horak D, Lednický F, Petrovský E, Kapička A. Magnetic characteristics of ferrimagnetic microspheres prepared by dispersion polymerization. Macromolecular Materials and Engineering. 2004;289(4):341-8.
  • Uygun DA, Karagözler AA, Akgöl S, Denizli A. Magnetic hydrophobic affinity nanobeads for lysozyme separation. Materials Science and Engineering: C. 2009;29(7):2165-73.
  • Safarik I, Safarikova M. Magnetic techniques for the isolation and purification of proteins and peptides. BioMagnetic Research and Technology. 2004;2(1):1.
  • Özkara S, Akgöl S, Çanak Y, Denizli A. A Novel Magnetic Adsorbent for Immunoglobulin‐G Purification in a Magnetically Stabilized Fluidized Bed. Biotechnology progress. 2004;20(4):1169-75.
  • Takahashi K, Hiwada K, Kokubu T. Occurrence of anti-gizzard P34K antibody cross-reactive components in bovine smooth muscles and non-smooth muscle tissues. Life sciences. 1987;41(3):291-6.
  • Hu T-T, Wu J-Y. Study on the characteristics of a biological fluidized bed in a magnetic field. Chemical engineering research & design. 1987;65(3):238-42.
  • Burns MA, Graves DJ. Continuous affinity chromatography using a magnetically stabilized fluidized bed. Biotechnology progress. 1985;1(2):95-103.
  • Rebroš M, Rosenberg M, Mlichova Z, Krištofíková Ľ. Hydrolysis of sucrose by invertase entrapped in polyvinyl alcohol hydrogel capsules. Food Chemistry. 2007;102(3):784-7.
  • Denizli A, Özkan G, Arica MY. Preparation and characterization of magnetic polymethylmethacrylate microbeads carrying ethylene diamine for removal of Cu (II), Cd (II), Pb (II), and Hg (II) from aqueous solutions. Journal of applied polymer science. 2000;78(1):81-9.
  • Xue B, Sun Y. Protein adsorption equilibria and kinetics to a poly (vinyl alcohol)-based magnetic affinity support. Journal of Chromatography A. 2001;921(2):109-19.
  • Tüzmen N, Kalburcu T, Denizli A. α-Amylase immobilization onto dye attached magnetic beads: Optimization and characterization. Journal of Molecular Catalysis B: Enzymatic. 2012;78:16-23.
  • Martin C, Cuellar J. Synthesis of a novel magnetic resin and the study of equilibrium in cation exchange with amino acids. Industrial & engineering chemistry research. 2004;43(2):475-85.
  • Akgöl S, Türkmen D, Denizli A. Cu (II)‐incorporated, histidine‐containing, magnetic‐metal‐complexing beads as specific sorbents for the metal chelate affinity of albumin. Journal of applied polymer science. 2004;93(6):2669-77.
  • Altıntaş EB, Uzun L, Denizli A. Synthesis and characterization of monosize magnetic poly (glycidyl methacrylate) beads. China Part. 2007;5(1):174-9.
  • Tong XD, Sun Y. Application of magnetic agarose support in liquid magnetically stabilized fluidized bed for protein adsorption. Biotechnology progress. 2003;19(6):1721-7.
  • Çorman ME, Öztürk N, Tüzmen N, Akgöl S, Denizli A. Magnetic polymeric nanospheres as an immobilized metal affinity chromatography (IMAC) support for catalase. Biochemical Engineering Journal. 2010;49(2):159-64.
  • Shan Z, Wu Q, Wang X, Zhou Z, Oakes KD, Zhang X, et al. Bacteria capture, lysate clearance, and plasmid DNA extraction using pH-sensitive multifunctional magnetic nanoparticles. Analytical biochemistry. 2010;398(1):120-2.
  • Nie L, Gao L, Yan X, Wang T. Functionalized tetrapod-like ZnO nanostructures for plasmid DNA purification, polymerase chain reaction and delivery. Nanotechnology. 2006;18(1):015101.
  • Reddy DHK, Yun Y-S. Spinel ferrite magnetic adsorbents: Alternative future materials for water purification? Coordination Chemistry Reviews. 2016;315:90-111.
  • Kose K, Denizli A. Poly(hydroxyethyl methacrylate) based magnetic nanoparticles for lysozyme purification from chicken egg white. Artif Cell Nanomed B. 2013;41(1):13-20.
  • Köse K. Nucleotide incorporated magnetic microparticles for isolation of DNA. Process Biochemistry.
  • Köse K, Erol K, Emniyet AA, Köse DA, Avcı GA, Uzun L. Fe(II)-Co(II) Double Salt Incorporated Magnetic Hydrophobic Microparticles for Invertase Adsorption. Applied Biochemistry and Biotechnology. 2015;177(5):1025-39.
  • Erol K, Kose K, Kose DA, Sizir U, Satir IT, Uzun L. Adsorption of Victoria Blue R (VBR) dye on magnetic microparticles containing Fe(II)-Co(II) double salt. Desalination and Water Treatment. 2016;57(20):9307-17.
  • Hur D, Ekti SF, Say R. N-Acylbenzotriazole mediated synthesis of some methacrylamido amino acids. Letters in Organic Chemistry. 2007;4(8):585-7.
  • Erol K, Köse K, Köse DA, Sızır Ü, Tosun Satır İ, Uzun L. Adsorption of Victoria Blue R (VBR) dye on magnetic microparticles containing Fe (II)–Co (II) double salt. Desalination and Water Treatment. 2016;57(20):9307-17.
  • Kara A, Osman B, Yavuz H, Beşirli N, Denizli A. Immobilization of α-amylase on Cu 2+ chelated poly (ethylene glycol dimethacrylate-n-vinyl imidazole) matrix via adsorption. Reactive and Functional Polymers. 2005;62(1):61-8.
  • Fabian K, Hubert A. Shape-induced pseudo-single-domain remanence. Geophysical Journal International. 1999;138(3):717-26.
  • Baberschke K. Anisotropy in Magnetism. In: Baberschke K, Nolting W, Donath M, editors. Band-Ferromagnetism: Ground-State and Finite-Temperature Phenomena. Berlin, Heidelberg: Springer Berlin Heidelberg; 2001. p. 27-45.
Year 2016, Volume: 3 Issue: 3, 185 - 204, 08.01.2017
https://doi.org/10.18596/jotcsa.74979

Abstract

References

  • Josephson L, Tung C-H, Moore A, Weissleder R. High-efficiency intracellular magnetic labeling with novel superparamagnetic-Tat peptide conjugates. Bioconjugate chemistry. 1999;10(2):186-91.
  • Partington KM, Jenkinson EJ, Anderson G. A novel method of cell separation based on dual parameter immunomagnetic cell selection. Journal of immunological methods. 1999;223(2):195-205.
  • Türkmen D, Yavuz H, Denizli A. Synthesis of tentacle type magnetic beads as immobilized metal chelate affinity support for cytochrome c adsorption. International journal of biological macromolecules. 2006;38(2):126-33.
  • Park J-H, Im K-H, Lee S-H, Kim D-H, Lee D-Y, Lee Y-K, et al. Preparation and characterization of magnetic chitosan particles for hyperthermia application. Journal of Magnetism and Magnetic Materials. 2005;293(1):328-33.
  • Lübbe AS, Alexiou C, Bergemann C. Clinical applications of magnetic drug targeting. Journal of Surgical Research. 2001;95(2):200-6.
  • Hinds KA, Hill JM, Shapiro EM, Laukkanen MO, Silva AC, Combs CA, et al. Highly efficient endosomal labeling of progenitor and stem cells with large magnetic particles allows magnetic resonance imaging of single cells. Blood. 2003;102(3):867-72.
  • Mornet S, Vasseur S, Grasset F, Duguet E. Magnetic nanoparticle design for medical diagnosis and therapy. Journal of Materials Chemistry. 2004;14(14):2161-75.
  • Serda RE, Adolphi NL, Bisoffi M, Sillerud LO. Targeting and cellular trafficking of magnetic nanoparticles for prostate cancer imaging. Molecular imaging. 2007;6(4):277.
  • Ranzoni A, Sabatte G, van IJzendoorn LJ, Prins MW. One-step homogeneous magnetic nanoparticle immunoassay for biomarker detection directly in blood plasma. Acs Nano. 2012;6(4):3134-41.
  • Fee CJ. Stability of the liquid‐fluidized magnetically stabilized fluidized bed. AIChE journal. 1996;42(5):1213-9.
  • Graves D. Bioseparations in the Magnetically Stabilized Fluidized Bed, Chapter 9, 187 207 Barker and Ganetsos, Eds., Preparative and Production Scale Chromatography. Marcel Dekker, Inc., NY; 1993.
  • Sawakami-Kobayashi K, Segawa O, Obata K, Hornes E, Yohda M, Tajima H, et al. Multipurpose robot for automated cycle sequencing. Biotechniques. 2003;34(3):634-7.
  • Tanaka T, Matsunaga T. Fully automated chemiluminescence immunoassay of insulin using antibody-protein A-bacterial magnetic particle complexes. Analytical chemistry. 2000;72(15):3518-22.
  • Idil N, Perçin I, Karakoç V, Yavuz H, Aksöz N, Denizli A. Concanavalin A immobilized magnetic poly (glycidyl methacrylate) beads for prostate specific antigen binding. Colloids and Surfaces B: Biointerfaces. 2015;134:461-8.
  • Zheng W, Gao F, Gu H. Carboxylated magnetic polymer nanolatexes: preparation, characterization and biomedical applications. Journal of magnetism and magnetic materials. 2005;293(1):199-205.
  • Pollert E, Knížek K, Maryško M, Závěta K, Lančok A, Boháček J, et al. Magnetic poly (glycidyl methacrylate) microspheres containing maghemite prepared by emulsion polymerization. Journal of magnetism and magnetic materials. 2006;306(2):241-7.
  • Lea T, Vartdal F, Davies C, Ugelstad J. Magnetic monosized polymer particles for fast and specific fractionation of human mononuclear cells. Scandinavian journal of immunology. 1985;22(2):207-16.
  • Ramanujan R, Chong W. The synthesis and characterization of polymer coated iron oxide microspheres. Journal of Materials Science: Materials in Medicine. 2004;15(8):901-8.
  • Jayachandran KNN, Chatterji PR. Preparation of linear and crosslinked polymer microspheres by dispersion polymerization. Journal of Macromolecular Science, Part C: Polymer Reviews. 2001;41(1-2):79-94.
  • Horak D, Lednický F, Petrovský E, Kapička A. Magnetic characteristics of ferrimagnetic microspheres prepared by dispersion polymerization. Macromolecular Materials and Engineering. 2004;289(4):341-8.
  • Uygun DA, Karagözler AA, Akgöl S, Denizli A. Magnetic hydrophobic affinity nanobeads for lysozyme separation. Materials Science and Engineering: C. 2009;29(7):2165-73.
  • Safarik I, Safarikova M. Magnetic techniques for the isolation and purification of proteins and peptides. BioMagnetic Research and Technology. 2004;2(1):1.
  • Özkara S, Akgöl S, Çanak Y, Denizli A. A Novel Magnetic Adsorbent for Immunoglobulin‐G Purification in a Magnetically Stabilized Fluidized Bed. Biotechnology progress. 2004;20(4):1169-75.
  • Takahashi K, Hiwada K, Kokubu T. Occurrence of anti-gizzard P34K antibody cross-reactive components in bovine smooth muscles and non-smooth muscle tissues. Life sciences. 1987;41(3):291-6.
  • Hu T-T, Wu J-Y. Study on the characteristics of a biological fluidized bed in a magnetic field. Chemical engineering research & design. 1987;65(3):238-42.
  • Burns MA, Graves DJ. Continuous affinity chromatography using a magnetically stabilized fluidized bed. Biotechnology progress. 1985;1(2):95-103.
  • Rebroš M, Rosenberg M, Mlichova Z, Krištofíková Ľ. Hydrolysis of sucrose by invertase entrapped in polyvinyl alcohol hydrogel capsules. Food Chemistry. 2007;102(3):784-7.
  • Denizli A, Özkan G, Arica MY. Preparation and characterization of magnetic polymethylmethacrylate microbeads carrying ethylene diamine for removal of Cu (II), Cd (II), Pb (II), and Hg (II) from aqueous solutions. Journal of applied polymer science. 2000;78(1):81-9.
  • Xue B, Sun Y. Protein adsorption equilibria and kinetics to a poly (vinyl alcohol)-based magnetic affinity support. Journal of Chromatography A. 2001;921(2):109-19.
  • Tüzmen N, Kalburcu T, Denizli A. α-Amylase immobilization onto dye attached magnetic beads: Optimization and characterization. Journal of Molecular Catalysis B: Enzymatic. 2012;78:16-23.
  • Martin C, Cuellar J. Synthesis of a novel magnetic resin and the study of equilibrium in cation exchange with amino acids. Industrial & engineering chemistry research. 2004;43(2):475-85.
  • Akgöl S, Türkmen D, Denizli A. Cu (II)‐incorporated, histidine‐containing, magnetic‐metal‐complexing beads as specific sorbents for the metal chelate affinity of albumin. Journal of applied polymer science. 2004;93(6):2669-77.
  • Altıntaş EB, Uzun L, Denizli A. Synthesis and characterization of monosize magnetic poly (glycidyl methacrylate) beads. China Part. 2007;5(1):174-9.
  • Tong XD, Sun Y. Application of magnetic agarose support in liquid magnetically stabilized fluidized bed for protein adsorption. Biotechnology progress. 2003;19(6):1721-7.
  • Çorman ME, Öztürk N, Tüzmen N, Akgöl S, Denizli A. Magnetic polymeric nanospheres as an immobilized metal affinity chromatography (IMAC) support for catalase. Biochemical Engineering Journal. 2010;49(2):159-64.
  • Shan Z, Wu Q, Wang X, Zhou Z, Oakes KD, Zhang X, et al. Bacteria capture, lysate clearance, and plasmid DNA extraction using pH-sensitive multifunctional magnetic nanoparticles. Analytical biochemistry. 2010;398(1):120-2.
  • Nie L, Gao L, Yan X, Wang T. Functionalized tetrapod-like ZnO nanostructures for plasmid DNA purification, polymerase chain reaction and delivery. Nanotechnology. 2006;18(1):015101.
  • Reddy DHK, Yun Y-S. Spinel ferrite magnetic adsorbents: Alternative future materials for water purification? Coordination Chemistry Reviews. 2016;315:90-111.
  • Kose K, Denizli A. Poly(hydroxyethyl methacrylate) based magnetic nanoparticles for lysozyme purification from chicken egg white. Artif Cell Nanomed B. 2013;41(1):13-20.
  • Köse K. Nucleotide incorporated magnetic microparticles for isolation of DNA. Process Biochemistry.
  • Köse K, Erol K, Emniyet AA, Köse DA, Avcı GA, Uzun L. Fe(II)-Co(II) Double Salt Incorporated Magnetic Hydrophobic Microparticles for Invertase Adsorption. Applied Biochemistry and Biotechnology. 2015;177(5):1025-39.
  • Erol K, Kose K, Kose DA, Sizir U, Satir IT, Uzun L. Adsorption of Victoria Blue R (VBR) dye on magnetic microparticles containing Fe(II)-Co(II) double salt. Desalination and Water Treatment. 2016;57(20):9307-17.
  • Hur D, Ekti SF, Say R. N-Acylbenzotriazole mediated synthesis of some methacrylamido amino acids. Letters in Organic Chemistry. 2007;4(8):585-7.
  • Erol K, Köse K, Köse DA, Sızır Ü, Tosun Satır İ, Uzun L. Adsorption of Victoria Blue R (VBR) dye on magnetic microparticles containing Fe (II)–Co (II) double salt. Desalination and Water Treatment. 2016;57(20):9307-17.
  • Kara A, Osman B, Yavuz H, Beşirli N, Denizli A. Immobilization of α-amylase on Cu 2+ chelated poly (ethylene glycol dimethacrylate-n-vinyl imidazole) matrix via adsorption. Reactive and Functional Polymers. 2005;62(1):61-8.
  • Fabian K, Hubert A. Shape-induced pseudo-single-domain remanence. Geophysical Journal International. 1999;138(3):717-26.
  • Baberschke K. Anisotropy in Magnetism. In: Baberschke K, Nolting W, Donath M, editors. Band-Ferromagnetism: Ground-State and Finite-Temperature Phenomena. Berlin, Heidelberg: Springer Berlin Heidelberg; 2001. p. 27-45.
There are 47 citations in total.

Details

Journal Section Articles
Authors

Kazım Köse

Publication Date January 8, 2017
Submission Date August 16, 2016
Published in Issue Year 2016 Volume: 3 Issue: 3

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Vancouver Köse K. Characterization of Magnetic Polymeric Microparticles. JOTCSA. 2017;3(3):185-204.