NOVEL ANTIMONY(III) HALIDE COMPLEXES WITH SOME N-ALKYL THIOUREAS: SYNTHESIS, CHARACTERIZATION AND STUDY OF THEIR EFFECT UPON THE CATALYTIC OXIDATION OF LINOLEIC ACID TO HYDROPEROXYLINOLEIC ACID BY LIPOXYGENASE

Year 2017, Volume: 4 Issue: 1, 81 - 98, 09.01.2017

İbrahim İsmet Öztürk

https://doi.org/10.18596/jotcsa.31798

Cited By: 1

Abstract

Four novel antimony(III) compounds (SbX₃; X = Cl or Br) of thiourea derivatives; N-methylthiourea (NMTU)  and N-ethylthiourea (NETU) of formulae [SbCl₃(NMTU)₃] (1), [SbBr₃(NMTU)₃] (2), [SbCl₃(NETU)₃] (3) and [SbBr₃(NETU)₃] (4) were synthesized. These new antimony(III) halide compounds were characterized by melting point, elemental analysis, molar conductivity, FT-Infrared spectroscopy, FT-Raman spectroscopy, UV-Vis spectroscopy, NMR (¹H and ¹³C) spectroscopy and TG-DTA analysis. The reactions of N-methylthiourea (NMTU) and N-ethylthiourea (NETU) with SbX₃ (X = Cl or Br) in a 2:1 ligand/metal rate but unexpectedly products were formed in a 3:1 ligand/metal rate. The compounds are non-electrolytes in solution and spectroscopic data of the compounds are appropriate with six coordinate octahedral geometry by three halide ions and three sulfur atoms from thiourea ligands. N-methythiourea and N-ethylthiourea ligands behave as monodentate in compounds 1-4 with the binding through sulfur.  The influence of these compounds 1–4, N-methythiourea and N-ethylthiourea upon the catalytic peroxidation of linoleic acid to hyperoxolinoleic acid by lipoxygenase was kinetically studied. 

Keywords

Antimony(III) halide compounds, N-alkyl thioureas, Spectroscopic Characterization, Lipoxygenase

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