Year 2017, Volume 4 , Issue 1, Pages 313 - 326 2017-01-09

Novel metal complexes of mixed piperaquine-acetaminophen and piperaquine-acetylsalicylic acid: Synthesis, characterization and antimicrobial activities

Yusuf Oloruntoyin Ayipo [1] , Joshua Ayoola Obaleye [2] , Umar Muhammad Badeggi [3]

Synthesis of coordination compounds of Zinc(II), Copper(II), Nickel(II), Cobalt(II) and Iron(II) with mixed piperaquine-acetaminophen and piperaquine-acetylsalicylic acid has been studied. The complexes were characterized via: solubility test, melting point determination, conductivity measurement, Atomic Absorption Spectroscopy, UV-Visible Spectroscopy, FTIR Spectroscopy and magnetic susceptibility. The complexes were proposed to have a stoichiometry ratio of 1:1:1 between each metal salt and the ligands with tetrahedral and octahedral geometry following the reaction pattern of MX.yH2O + L1L2/3 to give ML1L2/3X.yH2O. Biological activities of the synthesized complexes have been evaluated against Escherichia coli and Staphylococcus aureus.

Antimalaria, Analgesic, Mixed ligands, Metal complexes, Spectroscopy, Biological activities
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Journal Section Articles

Author: Yusuf Oloruntoyin Ayipo

Author: Joshua Ayoola Obaleye

Author: Umar Muhammad Badeggi


Application Date : October 7, 2016
Acceptance Date : November 28, 2020
Publication Date : January 9, 2017

Vancouver Ayipo Y , Obaleye J , Badeggi U . Novel metal complexes of mixed piperaquine-acetaminophen and piperaquine-acetylsalicylic acid: Synthesis, characterization and antimicrobial activities. Journal of the Turkish Chemical Society Section A: Chemistry. 2017; 313-326.