Year 2017, Volume 4 , Issue 1, Pages 313 - 326 2017-01-09

Novel metal complexes of mixed piperaquine-acetaminophen and piperaquine-acetylsalicylic acid: Synthesis, characterization and antimicrobial activities

Yusuf Oloruntoyin Ayipo [1] , Joshua Ayoola Obaleye [2] , Umar Muhammad Badeggi [3]


Synthesis of coordination compounds of Zinc(II), Copper(II), Nickel(II), Cobalt(II) and Iron(II) with mixed piperaquine-acetaminophen and piperaquine-acetylsalicylic acid has been studied. The complexes were characterized via: solubility test, melting point determination, conductivity measurement, Atomic Absorption Spectroscopy, UV-Visible Spectroscopy, FTIR Spectroscopy and magnetic susceptibility. The complexes were proposed to have a stoichiometry ratio of 1:1:1 between each metal salt and the ligands with tetrahedral and octahedral geometry following the reaction pattern of MX.yH2O + L1L2/3 to give ML1L2/3X.yH2O. Biological activities of the synthesized complexes have been evaluated against Escherichia coli and Staphylococcus aureus.

Antimalaria, Analgesic, Mixed ligands, Metal complexes, Spectroscopy, Biological activities
  • Wiesner J., Ortmann R., Jomaa H., and Schlitzer M., New Antimalarial Drugs, Angew. Chem. Internat. Ed. Engl., 2003, 42 (43) , 5274-5293.
  • Maribel N., Techniques used to Study MetalloDrugs-DNA interactions, Ivic Instituto Venezolano De Investigaciones Cientifica, 23-30 Julio, 2010.
  • World Health Organisation, Model Formulary for Children (2nd ed.), 2010, ISBN 978-92-4-159932-0. http://www.who.int/entity/selection_medicines/list/WMFc_2010.pdf. Retrieved 2011-03-30
  • World Health Organisation, Model List of Essential Medicines for Children (2nded.), 2010, http://www.who.int/entity/medicines/publications/essentialmedicines/Updated_second_children_list_en.pdf. Retrieved 2011-03-30.
  • Obaleye J. A., Amolegbe S. A. and Gbotoso G. O., Some metal-antimalarial drug complexes: synthesis, characterization and their effect against malaria parasites, http://www.journal.unaab.edu.ng/index.php/COLNAS/article/viewFile/193/190, 2006.
  • Olliaro P. L. and Taylor W. R., Antimalarial compounds: from bench to bedside. J Exp Biol, 2003, 206:3753-3759.
  • Marcus J. R., Rose M., Machteld E. B., Marion B., Stephane P., Mupawjay P., Pratap S. and Francois N., Dihydroartemisinin-Piperaquine Rescue Treatment of Multidrug-resistant Plasmodium Falciparum Malaria in Pregnanc. American Journal of Tropical Medicine and Hygiene, 2008, 78 (4) 543 – 545.
  • Sanjukta B. Ranbaxy Laboratory Ltd., India. www.synriam.com/2synriamRanbaxy.pdf, 2013.
  • Ogunniran K. O., Ajani O. O., Ehi-Eromosele C. O., Obaleye J. A., Adekoya J. A. and Ajanaku C. O., Cu(II) and Fe(III) complexes of sulphadoxine mixed with pyramethamine: synthesis, characterization, antimicrobial and toxicology study. International Journal of Physical Science, 2012, Vol. 7(13), pp 1998 – 2005.
  • Shruti S. S., Jadhav W. N., Khade B. C. and Arbad B. R., Synthesis, characterization and antimicrobial study of some 3d metal complexes of sulfadoxine. International Journal of ChemTech Research, 2014, Vol. 6, No 4, pp 2291 – 2294.
  • Cotton F. A., Geoffrey W. and Carlos A. M., Advanced Inorganic Chemistry, Wiley, New York, NY, 1988, 6th Ed. ISBN: 978-0-471-19957-1
  • Miessler G. L.; Donald A. T., Inorganic Chemistry, Pearson Education Inc., U. S. A., 1999, pp. 642. ISBN: 978-0321811059
  • Encyclopedia Britannica, https://en.wikipedia.org/wiki/Encyclopædia_Britannica, 2010.
  • Adediji J. F., Olayinka E. T., Adebayo M. A. and Babatunde O., Antimalarial mixed ligand metal complexes: Synthesis, physicochemical and biological activities. International Journal of Physical Sciences, 2009, 4 (9) 529 – 534.
  • Lee, J. D., Coincise Inorganic Chemistry; Wiley: India, 1999, pp 223 – 232.
  • Karunajeewa H., Lim C., Hung T. Y., Ilett K. F., Denis M. B., Socheat D. and Davis T. M., Safety evaluation of fixed combination piperaquine plus dihydroartemisinin (Artekin) in Cambodian children and adults with malaria. Br J Clin Pharmacol, 2004, 57:93-99.
  • Lawal A. and Obaleye J. A., Synthesis, characterization and antibacterial activity of aspirin and paracetamol-metal complexes. BIOKEMISTRY, 2006, 19 (1): 9-15.
  • Wikipedia: en.wikibooks.org/wiki/Inorganic_Chemistry/Qualitative_Analysis/Tests_for_anions
Journal Section Articles
Authors

Author: Yusuf Oloruntoyin Ayipo

Author: Joshua Ayoola Obaleye

Author: Umar Muhammad Badeggi

Dates

Application Date : October 7, 2016
Acceptance Date : November 15, 2019
Publication Date : January 9, 2017

Bibtex @ { jotcsa287331, journal = {Journal of the Turkish Chemical Society Section A: Chemistry}, issn = {}, eissn = {2149-0120}, address = {}, publisher = {Turkish Chemical Society}, year = {2017}, volume = {4}, pages = {313 - 326}, doi = {10.18596/jotcsa.287331}, title = {Novel metal complexes of mixed piperaquine-acetaminophen and piperaquine-acetylsalicylic acid: Synthesis, characterization and antimicrobial activities}, key = {cite}, author = {Ayipo, Yusuf Oloruntoyin and Obaleye, Joshua Ayoola and Badeggi, Umar Muhammad} }
APA Ayipo, Y , Obaleye, J , Badeggi, U . (2017). Novel metal complexes of mixed piperaquine-acetaminophen and piperaquine-acetylsalicylic acid: Synthesis, characterization and antimicrobial activities. Journal of the Turkish Chemical Society Section A: Chemistry , 4 (1) , 313-326 . DOI: 10.18596/jotcsa.287331
MLA Ayipo, Y , Obaleye, J , Badeggi, U . "Novel metal complexes of mixed piperaquine-acetaminophen and piperaquine-acetylsalicylic acid: Synthesis, characterization and antimicrobial activities". Journal of the Turkish Chemical Society Section A: Chemistry 4 (2017 ): 313-326 <https://dergipark.org.tr/en/pub/jotcsa/issue/27291/287331>
Chicago Ayipo, Y , Obaleye, J , Badeggi, U . "Novel metal complexes of mixed piperaquine-acetaminophen and piperaquine-acetylsalicylic acid: Synthesis, characterization and antimicrobial activities". Journal of the Turkish Chemical Society Section A: Chemistry 4 (2017 ): 313-326
RIS TY - JOUR T1 - Novel metal complexes of mixed piperaquine-acetaminophen and piperaquine-acetylsalicylic acid: Synthesis, characterization and antimicrobial activities AU - Yusuf Oloruntoyin Ayipo , Joshua Ayoola Obaleye , Umar Muhammad Badeggi Y1 - 2017 PY - 2017 N1 - doi: 10.18596/jotcsa.287331 DO - 10.18596/jotcsa.287331 T2 - Journal of the Turkish Chemical Society Section A: Chemistry JF - Journal JO - JOR SP - 313 EP - 326 VL - 4 IS - 1 SN - -2149-0120 M3 - doi: 10.18596/jotcsa.287331 UR - https://doi.org/10.18596/jotcsa.287331 Y2 - 2019 ER -
EndNote %0 Journal of the Turkish Chemical Society Section A: Chemistry Novel metal complexes of mixed piperaquine-acetaminophen and piperaquine-acetylsalicylic acid: Synthesis, characterization and antimicrobial activities %A Yusuf Oloruntoyin Ayipo , Joshua Ayoola Obaleye , Umar Muhammad Badeggi %T Novel metal complexes of mixed piperaquine-acetaminophen and piperaquine-acetylsalicylic acid: Synthesis, characterization and antimicrobial activities %D 2017 %J Journal of the Turkish Chemical Society Section A: Chemistry %P -2149-0120 %V 4 %N 1 %R doi: 10.18596/jotcsa.287331 %U 10.18596/jotcsa.287331
ISNAD Ayipo, Yusuf Oloruntoyin , Obaleye, Joshua Ayoola , Badeggi, Umar Muhammad . "Novel metal complexes of mixed piperaquine-acetaminophen and piperaquine-acetylsalicylic acid: Synthesis, characterization and antimicrobial activities". Journal of the Turkish Chemical Society Section A: Chemistry 4 / 1 (January 2017): 313-326 . https://doi.org/10.18596/jotcsa.287331
AMA Ayipo Y , Obaleye J , Badeggi U . Novel metal complexes of mixed piperaquine-acetaminophen and piperaquine-acetylsalicylic acid: Synthesis, characterization and antimicrobial activities. JOTCSA. 2017; 4(1): 313-326.
Vancouver Ayipo Y , Obaleye J , Badeggi U . Novel metal complexes of mixed piperaquine-acetaminophen and piperaquine-acetylsalicylic acid: Synthesis, characterization and antimicrobial activities. Journal of the Turkish Chemical Society Section A: Chemistry. 2017; 4(1): 326-313.