Synthesis of Chlorotoxin by Native Chemical Ligation

Year 2018, Volume: 5 Issue: 2, 845 - 856, 01.01.2018

Yuvaraj Tcm , Parameshwara Naik P Venkatesh T. V Krishnamurthy G , Manjuraj T

https://doi.org/10.18596/jotcsa.341379

Cited By: 1

Abstract

A series of Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) metal complexes are
derived from ligand (N-(3-methoxyphenyl)-2-[(2E)-3-phenylprop-2-enoyl]hydrazinecarboxamide[MPH],
and structurally characterized by various physicochemical and spectral tools such as IR,
UV-Visible, 1H-NMR, LC-Mass, powder XRD and TGA-DTC.These studies
showed that the ligand coordinated to the metal atom in a bidentate manner and
have octahedral environment.X-ray diffraction studies indicates that the Co(II)
and Cu(II) complexes are Crystalline in nature, Degradation mechanism, kinetic
and thermodynamic parameters of the synthesized metal complexes has been
evaluated.The synthesized compounds were evaluated for in vitroantioxidant
DPPH assay, in which metal complexes showed excellent activity. The molecular
docking analysis by using human antioxidant enzyme DTT (PDB: 3MNG)have
also been evaluated. The ligand and their metal complexes were screened for
their antifungal and antibacterial activities against different species of
pathogenic fungi and bacteria.

Keywords

Semicarbazide, Metal complexes. Powder XRD, TGA, antioxidant

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