Electrochemical oxidation pathway of the anti-cancer agent dasatinib using disposable pencil graphite electrode and its adsorptive stripping voltammetric determination in biological samples

Year 2018, Volume: 5 Issue: 2, 381 - 392, 01.01.2018

Dilek Eskiköy Bayraktepe , Kamran Polat , Zehra Yazan

https://doi.org/10.18596/jotcsa.345238

Cited By: 8

Abstract

The present study describes the
use of pencil graphite electrode (PGE) for the investigation of
electro-oxidation mechanism and voltammetric stripping determination of
dasatinib (DST) in Britton-Robinson buffer solution (BR). Relating to cyclic
voltammetric studies, an irreversible oxidation signal was obtained at about
1.0 V. The oxidation electrode process is adsorption-controlled and
pH-dependent. For quantitative determination of DST, square wave adsorptive
stripping voltammetry (AdsSWV) was employed in BR of pH 3.0. The oxidation peak
current varies linearly with the DST concentration in the range of 0.0092 – 1.0
µM. Dedection (LOD)
and quantification (LOQ) values are founded as 0.0028 µM and 0.0092 µM, respectively. The developed
AdsSWV method based on disposible and cheap PGE was applied successfuly to the real
urine samples and the recovery results are given in the range of 97.94% to
100.82%. 

Keywords

Dasatinib, pencil graphite electrode, voltammetry

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