In this paper, we investigated the mineralization
of hydrochlorothiazide, a diuretic drug which is used for the treatment of
hypertension, using H2O2 as the oxidizing agent in
subcritical water as a medium. Response surface methodology was applied to
optimize experimental parameters such as temperature, treatment time, and
concentration of the oxidizing agent. 85.22% of TOC removal was obtained at 403
K, 80 mM of hydrogen peroxide and 147.3 min. The reliability of the performed
method was evaluated by ANOVA and the theoretical equation of TOC removal of hydrochlorothiazide
was proposed. F and p values of the model were determined as
62.88 and lower than 0.0001, respectively.
Hydrochlorothiazide Degradation Subcritical water Hydrogen peroxide Response surface methodology
Primary Language | English |
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Subjects | Chemical Engineering |
Journal Section | Articles |
Authors | |
Publication Date | September 1, 2018 |
Submission Date | August 1, 2018 |
Acceptance Date | September 18, 2018 |
Published in Issue | Year 2018 Volume: 5 Issue: 3 |