Inhibition of DNase I Enzyme with Nickel(II) Triphenylphosphine Complexes Incorporating Tridentate Schiff Base Ligands in Vitro

Year 2018, Volume: 5 Issue: 3, 1399 - 1406, 01.09.2018

Şükriye Güveli

https://doi.org/10.18596/jotcsa.472530

Cited By: 3

Abstract

The
nickel(II) complexes containing 3-methoxy-salicylaldehyde-N⁴-R thiosemicarbazones
(R:-H₂,-propyl)with triphenylphosphine coligands have been
synthesized. The structure of Ni(II)-centered metal complex was approved by
elemental analysis and melting point. The solid-state structure of complex 2 bearing PPh₃ as co-ligand was
clarified by single crystal X-ray crystallography, which revealed square planar
geometry around Ni(II) ion. Thiosemicarbazone
ligands are coordinated by ONS mode to nickel(II). The potential of these complexes to inhibit the DNase I enzyme, which
uses DNA as a substrate, was investigated in vitro. The results revealed that
the compounds inhibited the DNase enzyme in directly and/or indirectly (by
masking of DNA molecules) at ≥0.1 µg/ml concentrations in vitro.

Keywords

Nickel(II) complexes , thiosemicarbazones , X-ray crystallography , DNase I

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