Doping Agent Naphazoline Hydrochloride: Development of Simple and Fast Voltammetric Method for Its Determination in Human Serum

Year 2019, Volume: 6 Issue: 1, 79 - 88, 15.05.2019

Tuğçe Çetinkol Funda Öztürk , Pinar Esra Erden

https://doi.org/10.18596/jotcsa.450793

Cited By: 2

Abstract

Electrochemical
behavior of naphazoline hydrochloride on a carbon paste electrode that was modified
with aluminium oxide nanoparticles (Al₂O₃NPs) was
investigated in a Britton-Robinson (BR) buffer (pH 7.0) using various
voltammetric techniques. The results support the presence of an irreversible
and diffusion-controlled electrochemical oxidation signal of naphazoline
hydrochloride which is approximately at 0.9 V vs. Ag/AgCl. A selective,
accurate, and simple square-wave anodic adsorptive stripping voltammetric
method was purposed for naphazoline hydrochloride detection. The linear
response was within the range of 5.0 × 10^-8- 3.0 ×
10^-5 mol L^-1 with a detection limit of 2.6 × 10^–8
mol L^–1 (0.0064 mg L^–1). In addition, the purposed method
was also utilized for naphazoline hydrochloride determination in human serum
sample. 

Keywords

Aluminium oxide nanoparticles, doping agent, electrochemical techniques, naphazoline, human serum

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