Synthesis, Characterization, and Molecular Docking Studies of Fluoro and Chlorophenylhydrazine Schiff Bases

Year 2019, Volume: 6 Issue: 3, 303 - 310, 20.10.2019

Ayşegül Şenocak

https://doi.org/10.18596/jotcsa.535441

Abstract

Six Schiff bases synthesized by
condensation reaction of p-fluoro and chlorophenylhydrazines with some carbonyl
compounds were reported in this work. Structures of the prepared compounds were
elucidated by FT-IR, 1H- and 13C-NMR spectroscopy. FT-IR
spectra exhibited characteristic transitions for all compounds. Also, their
structures were proved by NMR spectroscopy, especially with the imine peak
which is an indicator of the formation of Schiff bases. In addition, molecular
docking studies of the Schiff bases were carried out on Alzheimer’s disease. The
calculated docking scores and inhibition constants pointed out the usage
probability of 2-chloro-5-nitrobenzaldehyde Schiff bases as a new drug
candidate for Alzheimer’s disease after structural regulations.

Keywords

Schiff base, Phenylhydrazine, NMR spectroscopy, Alzheimer’s disease, Cholinesterase, Molecular docking

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