Chitosan-drug encapsulation as a potential candidate for COVID-19 drug delivery systems: A review

Onome Ejeromedoghene; Olayinka Oderinde; George Egejuru; Sheriff Adewuyi

doi:10.18596/jotcsa.773780

Review

Chitosan-drug encapsulation as a potential candidate for COVID-19 drug delivery systems: A review

Year 2020, Volume: 7 Issue: 3, 851 - 864, 30.10.2020

Onome Ejeromedoghene , Olayinka Oderinde George Egejuru Sheriff Adewuyi

https://doi.org/10.18596/jotcsa.773780

Cited By: 8

Abstract

Since the outbreak of COVID-19, the World Health Organization (WHO), Centre for Disease Control (CDC), and other health organizations around the world have coordinated the flow of information and given out preventive directives measures and guidelines to reduce the impact and spread of the disease. Meanwhile, bodies of scientists and researchers around the world are still working ceaselessly to study the virus, mode of transmission mechanisms, and are rapidly developing therapeutic antiviral drugs and vaccines. Thus, the urgent need for the fabrication of biocompatible and biodegradable composite materials as drug delivery vehicles for the efficient loading, targeted delivery and controlled release of antiviral drugs to the target site is been inspired. Therefore, this review highlights the antimicrobial and antiviral activities of chitosan as well as the potency of a combined therapy via electrostatic/hydrogen bonding encapsulation onto the WHO suggested clinical trial drugs and possible chelation with metal ions to form new improved antiviral compounds as a promising agent for the targeted drug delivery.

Keywords

COVID-19, Biopolymeric chitosan, Antiviral agent, Drug delivery, Biocompatible, Antibiotics, Antibiotics

Supporting Institution

Southeast University, China

Project Number

N/A

Thanks

China Scholarship Council

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