Antimicrobial Activity Evaluation of Newly Synthesized N,N-Disubstituted Taurinamidobenzenesulfonamide Derivatives

Year 2021, Volume: 8 Issue: 1, 321 - 328, 28.02.2021

Özlem Akgül , Ayşegül Ateş , Şafak Ermertcan

https://doi.org/10.18596/jotcsa.834579

Cited By: 1

Abstract

Herein we synthesized 6 new N,N-disubstituted taurinamidobenzensulfonamide derivatives and characterized their structures by means of 1H and 13C NMR, HR-MS analysis. In addition, their in vitro antibacterial and antifungal activities were tested against two gram-positive, two gram-negative bacteria, and two fungal strains by using broth microdilution method. Compounds 1 (methoxy substitution) and 2 (methyl substitution) displayed the best antibacterial activity against Escherichia coli and Staphylococcus aureus, respectively. E. faecalis was affected by compounds 1, 2, 4, and 6, becoming the most susceptible pathogen compared to other tested bacterial and fungal strains. Interestingly, changing fluoro atom in compound 6 with the chloro atom, as in compound 5, deteriorated the antibacterial activity against all bacterial strains. As a result, these results provide us to investigate the relationship between structural changes and antibacterial/antifungal activity, which can be further used to develop more effective taurine derivatives.

Keywords

Taurine, taurinamidobenzensulfonamide, antibacterial, antifungal, microdilution

Supporting Institution

The Scientific and Technological Research Council of Turkey [TUBITAK; Project number: SBAG- 117S516] and Ege University Scientific Research Projects Coordination Unit [Project number: 16-ECZ-012].

Project Number

SBAG- 117S516, 16-ECZ-012.

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