Application of Oxidative Coupling Reaction using Brucine and Sodium Periodate as Chromogenic Reagent for the Assay of Perindopril Erbumine in Formulations

Year 2021, Volume: 8 Issue: 3, 803 - 810, 31.08.2021

Thuttagunta Manıkya Sastry Ramakrıshna Karıpeddı

https://doi.org/10.18596/jotcsa.757440

Abstract

The drug Perindopril Erbumine (PE), an ACE inhibitor, and can be used to treat the patients with hypertension and cardiac failure problems. A sensitive, inexpensive, and precise analytical technique has been developed for the estimation of Perindopril in bulk and formulations. The procedure involves the development of color by forming an oxidative coupling reaction between drug (PE) and Brucine/IO4-). The formed colored species were measured at max=520 nm. The developed method showed linearity within the concentration limits of 8-24 μg mL-1. The linear correlation coefficient (r) and molar absorptivity were found to be 0.9999 and 9.16 x 103 mol-1.cm-1. % Recovery ± SD values were in the range of 99.16 - 100.7 (± 0.41 - ± 0.8) (n=3) which indicates the accuracy of the developed method. The interference of other excipients that are commonly present in formulations is found to be negligible. Precision and accuracy of the proposed method were confirmed by Student’s t-test and F-tests at 95% confidence limits with (n-1) degrees of freedom. The validity parameters of the proposed method were calculated by ICH guidelines.

Keywords

Spectrophotometry, Perindopril Erbumine, Brucine, coversyl and perigard-DF.

Thanks

The authors are grateful to the management of Gayatri Vidya Parishad College of Engineering (Autonomous), Visakhapatnam for providing research laboratory facilities

References

• 1. Sweetman S C. In Martindale: The complete Drug Reference. Brayfield A, Buckingham R (eds). 36th Edition, Vol II, Pharmaceutical Press, London. 2009; p.928. ISBN: 9780857113672.
• 2. Budavari S (editor). The Merck Index: An Encyclopedia of Chemicals, Drugs and Biologicals. Merck & Co. Inc., 12th edition, White House Station, New Jersey. 1996; ISBN: 9780412756504.
• 3. British Pharmacopoeia : British pharmacopoeial Commission Office, vol I & vol II, London, UK. 2009; p. 4612.
• 4. Joseph PR and Alfonso R. Remington’s The Science and Practice of Pharmacy, Publisher, Lippincott Williams & Wilkins, 20th Edition, Baltimore, Maryland, USA. 2000; p. 1281. ISBN: 0-7817-4673-6.
• 5. Montvale, NJ. P.D.R.: ‘Physicians’ desk reference’, 54th Edn., Medical Economics Company Publisher, U.S. 2000; p. 3057. ISBN: 9781563633300.
• 6. Nayak SP, Pillai S. Simultaneous estimation of amlodipine besylate and perindopril erbumine by UV spectrophotometric method. Res J of Pharmacy and Technol. 2011; 4: 735-8.
• 7. Kale SS, Bakal RL, Chandewar AV, Sakhare RS. Two wavelength method for estimation of indapamide and perindopril erbumine in combined tablet dosage form. Res J Pharmacy Technol. 2011; 4: 545-8.
• 8. El-Gizawy SM, Abdelmageed OH, Derayea SM, Omar MA, Abdel-Megied AM. Chiral separation of perindopril erbumine enantiomers using high performance liquid chromatography and capillary electrophoresis. Anal Methods. 2014;6(3):825–30. DOI: https://doi.org/10.1039/C3AY42056F.
• 9. Gizawy SM, Bebawy LI, Abdelmageed OH, Omar MA, Deryea SM, Abdel-Megied AM. High Performance Liquid Chromatography, TLC-Densitometry, and First-Derivative Spectrophotometry for Simultaneous Determination of Amlodipine and Perindopril in Bulk Powder and its Tablets. Journal of Liquid Chromatography & Related Technologies. 2013 Apr;36(10):1323–39. DOI: https://doi.org/10.1080/10826076.2012.686141.
• 10. Pattan SR, Patni AC, Mali RA. Patni CJ, Godge RK, Bhawar HS and Marathe RP. Analytical method development and validation of perindopril erbumine and amlodipine besylate in bulk and tablet dosage form by HPLC. Indian Drugs. 2013;50:32–5.
• 11. Singh M, Kaskhedikar SG, Singhvi G, Soni L. HPLC estimation of perindopril erbumine in tablet dosage form. Asian J Chem. 2011; 23: 3909-11.
• 12. Chaudhary AB, Patel R, Chaudhary S. Determination of losartan potassium and perindopril erbumine in tablet formulations by reversed-phase HPLC. International Journal of ChemTech Research. 2010;2:1141–6.
• 13. Mastanamma S, Saidulu P, Sravanthi A, Rajitha E. Stability Indicating Validated RP-HPLC Method for Simultaneous Determination of Hydralazine Hydrochloride and Isosorbide Dinitrate in Bulk and Pharmaceutical Dosage Form. Int J Pharm Sci Rev Res. 2016;28:141–8.
• 14. Dugga HHT, Peraman R, Nayakanti D. Stability-Indicating RP-HPLC Method for the Quantitative Analysis of Perindopril Erbumine in Tablet Dosage Form. Journal of Chromatographic Science. 2014 Apr 1;52(4):315–20. DOI: https://doi.org/10.1093/chromsci/bmt031.
• 15. Joseph J, Philip B, Sundarapandian M. Method development and validation for simultaneous estimation of perindopril erbumine and indapamide by RP-HPLC in pharmaceutical dosage forms. International Journal of Pharmacy and Pharmaceutical Sciences. 2011;3(4):288–93.
• 16. Oza C, Prajapati J, Mehta P. RP-HPLC method for the determination of losartan potassium and perindopril erbumine in combined tablet dosage form. International Journal of Pharma and Bio Sciences. 2011;2(1):709–7015.
• 17. Prajapati J, Patel A, Patel M, Prajapati N, Prajapati R. Analytical method development and validation of Amlodipine besylate and Perindopril erbumine in combine dosage form by RP-HPLC. International Journal of PharmTech Research. 2011;3(2):801–8.
• 18. Prameela Rani A, Bala Sekaran C. A validated RP-HPLC method for the determination of Perindopril Erbumine in pharmaceutical formulations. Int J PharmTech Res. 2009; 1(3): 575-8.
• 19. Fael H, Sakur AA-H. Novel Spectrofluorimetric Method for the Determination of Perindopril Erbumine Based on Fluorescence Quenching of Rhodamine B. J Fluoresc. 2015 Nov;25(6):1577–84. DOI: https://doi.org/10.1007/s10895-015-1666-2.
• 20. Fael H, Sakur AA-H. Novel Spectrofluorimetric Method for the Determination of Perindopril Erbumine Based on Charge Transfer Reaction with 7-Hydroxycoumarin. J Fluoresc. 2015 Jul;25(4):811–8. DOI: https://doi.org/10.1007/s10895-015-1596-z.
• 21. Sridevi N, Jahnavi G, Sekaran CB. Spectrophotometric analysis of perindopril erbumine in bulk and tablets using bromophenol blue. Der Pharmacia Lettre. 2012;4(1):159–69.
• 22. Rahman N, Rahman H, Khatoon A. Development of Spectrophotometric Method for the Determination of Perindopril Erbumine in Pharmaceutical Formulations Using 2, 4 dinitrofluorobenzene. J Chil Chem Soc. 2012;57(2):1069–73. DOI: https://doi.org/10.4067/S0717-97072012000200002.
• 23. Rahman N, Rahman H. Quantitative analysis of perindopril erbumine in pharmaceutical preparations by spectrophotometry via ternary complex formation with Zn(II) and eosin and charge transfer complexation with iodine. Spectroscopy. 2011;25(2):123–36. DOI: https://doi.org/10.1155/2011/106936.
• 24. Rahman N, Rahman H, Haque SM. Kinetic spectrophotometric method for the determination of perindopril erbumine in pure and commercial dosage forms. Arabian Journal of Chemistry. 2017 Feb;10:S831–8. DOI: https://doi.org/10.1016/j.arabjc.2012.12.017.
• 25. Rahman N, Anwar N, Kashif M. Optimized and Validated Initial-Rate Method for the Determination of Perindopril Erbumine in Tablets. Chem Pharm Bull. 2006;54(1):33–6. DOI: https://doi.org/10.1248/cpb.54.33.
• 26. Jain DS, Subbaiah G, Sanyal M, Pande UC, Shrivastav P. First LC–MS/MS electrospray ionization validated method for the quantification of perindopril and its metabolite perindoprilat in human plasma and its application to bioequivalence study. Journal of Chromatography B. 2006 Jun;837(1–2):92–100. DOI: https://doi.org/10.1016/j.jchromb.2006.04.008.
• 27. Nirogi RVS, Kandikere VN, Shukla M, Mudigonda K, Maurya S, Komarneni P. High-throughput quantification of perindopril in human plasma by liquid chromatography/tandem mass spectrometry: application to a bioequivalence study. Rapid Commun Mass Spectrom. 2006 Jun 30;20(12):1864–70. DOI: https://doi.org/10.1002/rcm.2529.
• 28. Maurer HH, Kraemer T, Arlt JW. Screening for the Detection of Angiotensin-Converting Enzyme Inhibitors, Their Metabolites, and AT II Receptor Antagonists. Therapeutic Drug Monitoring [Internet]. 1998;20(6). URL: https://journals.lww.com/drug-monitoring/Fulltext/1998/12000/Screening_for_the_Detection_of.22.aspx.
• 29. Massart DL, editor. Chemometrics: a textbook. Amsterdam ; New York : New York, NY, U.S.A: Elsevier ; Distributors for the U.S. and Canada, Elsevier Science Pub. Co; 1988. 488 p. (Data handling in science and technology). ISBN: 978-0-444-42660-4.
• 30. Rao GR, Murthy SSN, Rao EV. Spectrophotometric determination of some sulphur compounds and tryptophan with brucine and sodium metaperiodate, Indian Drugs. 1985; 22: 484-8.
• 30. International Conference on Harmonisation Expert Working Group. International conference on harmonisation of technical requirements for registration of pharmaceuticals for human use. ICH harmonised tripartite guideline. Guideline for good clinical practice. 1997 CFR & ICH Guidelines. 1997;