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Traditional Medicinal Uses, Phytochemicals, and Pharmacological Activities of Genus Rhamnus: A review

Year 2021, Volume: 8 Issue: 3, 899 - 932, 31.08.2021
https://doi.org/10.18596/jotcsa.929188

Abstract

The genus Rhamnus belongs to the Rhamnaceae family, which contains approximately 137 species, traditionally used as folk medicine in East Asia, North and South America, and subtropical regions of Africa. The genus is used traditionally to treat diseases such as cancer, wound, jaundice, hepatitis, gonorrhea, laxative, hypertension, malaria, stomach ache, snake bite and diarrhea. Anthraquinones and flavonoids are the most cited compounds from the genus of which polyphenols were abundant with tremendous antioxidant, wound healing and antiinflammatory activities. Pharmacological activity evaluation of the extracts and isolated compounds revealed anti-inflammatory, antioxidant, antimalarial, antibacterial, anti-mutagenic, anti-genotoxic, hepatoprotective, anticancer, and anti-proliferative activity. The genus afforded drug leads such as 6-methoxysorigenin (12) and prinoidin (23) with anti-tyrosinase and cytotoxicity, respectively, as well as antioxidant drug leads such as Kaempferol-3-O-β-rhamninoside (31) rhamnetin-3-O-β-isorhamninoside (37) and isotorachrysone (55). The present review endeavors to provide a comprehensive and up to date compilation of documented traditional medicinal uses, phytochemicals and pharmacological activities of the genus and provided valuable information in support of its uses as an alternative medicine for future healthcare practice.

Thanks

Authors express their gratitude to Adama Science and Technology University for providing access to various journal databases.

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Year 2021, Volume: 8 Issue: 3, 899 - 932, 31.08.2021
https://doi.org/10.18596/jotcsa.929188

Abstract

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There are 132 citations in total.

Details

Primary Language English
Subjects Biochemistry and Cell Biology (Other)
Journal Section REVIEW ARTICLES
Authors

Gashaw Nigussie 0000-0002-7758-6367

Haregua Melak This is me 0000-0002-3375-8809

Milkyas Endale Annisa 0000-0002-5301-9923

Publication Date August 31, 2021
Submission Date April 28, 2021
Acceptance Date July 26, 2021
Published in Issue Year 2021 Volume: 8 Issue: 3

Cite

Vancouver Nigussie G, Melak H, Endale Annisa M. Traditional Medicinal Uses, Phytochemicals, and Pharmacological Activities of Genus Rhamnus: A review. JOTCSA. 2021;8(3):899-932.