Novel Green Method for the Spectrophotometric Determination of Metoclopramide Hydrochloride in Pharmaceutical Formulations

Year 2023, Volume: 10 Issue: 1, 193 - 204, 28.02.2023

Ghufran A. Alhammadi , Lamya A. Sarsam

https://doi.org/10.18596/jotcsa.1158403

Abstract

A less environmentally harmful reagent, 2-tert-Butyl-4-methoxyphenol (BHA), is used to evaluate Metoclopramide hydrochloride (MCP.H) by simple, rapid, sensitive, accurate and precise spectrophotometric method, through azo coupling reaction between metoclopramide hydrochloride medicine and it's pharmaceutical preparation by utilizing BHA as a reagent, (MCP.H) azo-dye formed shows the higher absorption peak at 504 nm. Absorbance- concentration relation is linear over the range from 20 to 280 µg / 5 mL, (i.e. 4-56 ppm) with a good sensitivity (molar absorptivity 0.26x104 L.mol-1.
cm-1); good precision (RSD better than 0.844 %) and high accuracy (relative error less than + 0.4%), Sandell's sensitivity index is -0.1293 µg.cm-2, the calculated limit of detection (LOD) is 0.0658 µg/mL and the evaluated limit of quantitation (LOQ) is 0.2193 µg/mL. The application has had successful results for the assay of metoclopramide hydrochloride in dosage forms of tablets and injection.

Keywords

butylated hydroxyanisole, metoclopramide hydrochloride, spectrophotomety, friendly environment

Thanks

The authors express their honest thanks to Department of Chemistry and New and Renewable Energies, College of Science, University of Mosul, Mosul, Iraq to benefit the research facilities.

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