3-Hydroxypyridine and 3-(Hydroxymethyl)pyridine in the Synthesis of Salts of Aryldithiophosphonic Acids on the Basis of Monoterpenyl Alcohols

Year 2023, Volume: 10 Issue: 4, 953 - 960, 11.11.2023

Ilyas Nizamov , Andrey Yakovlev , Ilnar Nizamov , Marina Shulaeva

https://doi.org/10.18596/jotcsa.1290931

Cited By: 1

Abstract

3-Hydroxypyridinium and 3-(hydroxymethyl)pyridinium O-terpenyl aryldithiophosphonates were obtained by the reactions of 3-hydroxypyridine and 3-(hydroxymethyl)pyridine with O-terpenyl aryldithiophosphonic acids on the basis of (1R,2S,5R)-(−)-menthol, (1S)-endo-(–)-borneol, racemic isoborneol, and carvacrol. The obtained salts possess high antimicrobial activity against Bacillus cereus and Candida albicans.

Keywords

3-Hydroxypyridine, 3-(hydroxymethyl)pyridine, dithiophosphonates, antimicrobial activity.

Thanks

This paper has been supported by the Kazan Federal University Strategic Academic Leadership Program (“PRIORITY-2030”), and the Russian Foundation for Basic Research (grants no. 18-415-160012-р_Volga Region_а). The authors are grateful to the staff of Distributed Spectral-Analytical Center of Shared Facilities for Study of Structure, Composition and Properties of Substances and Materials of Federal Research Center of Kazan Scientific Center of the Russian Academy of Sciences for their research and assistance in discussing the results. The researchers are thankful to Professor Oscar K. Pozdeev, Kazan State Medical Academy, Department of Microbiology, for biological evaluation.

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