Posaconazole loaded ocular inserts for antifungal activity

Year 2020, , 1 - 6, 01.04.2020

Kadir Aykaç , Evrim Yenilmez , Müzeyyen Demirel , Ebru Başaran

https://doi.org/10.37662/jpt.2020.0

Abstract

Corneal and conjunctival infections are common ocular diseases; however, sometimes lead to blindness when neglected. Despite most of the ocular drug delivery systems are in eye drop form, they suffer from poor retention on the ocular surface and low ocular bioavailability leading to unsatisfactory results even with repeated treatment. Therefore, there is a need for more effective drug delivery systems for the ocular application. The present study was carried out to demonstrate that ocular inserts effectively delivers a significant concentration of drug with topical administration for the treatment of fungal infections with the help of extended residence time on the ocular surface. Chitosan-based inserts were prepared by the freeze-drying method. The prepared inserts were evaluated for various parameters. Layered structures were revealed with scanning electron microscopy analyses. Thermal and structural behaviors were analyzed by differential scanning calorimetry and Fourier-transform infrared spectroscopy with nuclear magnetic resonance analyses, respectively. Drug contents were evaluated by a validated HPLC method. In vitro release studies were also performed in simulated tear fluid at 34±1°C for 48 hours. Analyses results revealed that chitosan-based ocular inserts were suitable systems for posaconazole delivery for the treatment of severe ocular fungal infections.

Keywords

Chitosan, In-Vitro Release, Ocular Bioavailability, Ocular Inserts, Posaconazole

Supporting Institution

Anadolu University Scientific Research Project Foundation

Project Number

BAP No:1901S006

Thanks

The study was financed by Anadolu University Scientific Research Project Foundation (BAP No:1901S006). Authors would like to thank to BIBAM management for SEM, and DOPNA-LAB for FT-IR and 1H-NMR analyses.

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