Year 2020, Volume 1 , Issue 1, Pages 25 - 39 2020-04-01

Brain-targeted nanoparticles to overcome the blood-brain barrier

Indrit SEKO [1] , Adem ŞAHİN [2] , Hayrettin TONBUL [3] , Yılmaz ÇAPAN [4]


The blood-brain barrier is one of the most complicated barrier to pass for therapeutic drugs. Because of the structure of the blood-brain barrier, only a few small molecules with appropriate lipophilicity, molecular weight, and charge can penetrate through the blood-brain barrier and pass in the central nervous system. Because of this unique property, blood-brain barrier is still a major problem for the treatment of central nervous system diseases. In the last decades, many strategies to overcome this barrier have been investigated. Compared to other drug delivery strategies, due to the reduced side effects and no requirement for surgical operations, brain targeted nanoparticle is one the most promising and popular strategy used do deliver drugs to the brain. Many in vitro and in vivo preclinical studies have been conducted to determine optimum brain targeted nanoparticles. These studies were reported that characteristics of nanoparticles such as particle size, zeta potential, and targeting ligand are critical to achieving the goals. In this review, first of all, the structure of the blood-brain barrier and possible causes of blood-brain barrier disruption were summarized. Later, previous strategies of brain targeted drug delivery and characteristic prosperities for optimized brain-targeted nanoparticles were evaluated. Moreover, different strategies, such as focus ultrasound, which can increase the effectiveness of nanoparticular system applications, are mentioned.
Brain Targeting, Nanoparticles, Particle Size, The Blood-Brain Barrier, Zeta Potential
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Primary Language en
Subjects Pharmacy, Pharmacology and Pharmacy
Journal Section Review Articles
Authors

Orcid: 0000-0002-9970-5195
Author: Indrit SEKO
Institution: Hacettepe University
Country: Turkey


Orcid: 0000-0002-3996-2931
Author: Adem ŞAHİN
Institution: SELCUK UNIVERSITY
Country: Turkey


Orcid: 0000-0001-5510-8973
Author: Hayrettin TONBUL
Institution: INONU UNIVERSITY
Country: Turkey


Orcid: 0000-0003-1234-9018
Author: Yılmaz ÇAPAN (Primary Author)
Institution: HACETTEPE UNIVERSITY
Country: Turkey


Thanks ChemDraw 15 Software (PerkinElmer, USA) was used for producing Graphical Abstract and Figure 1-2.
Dates

Application Date : May 25, 2020
Acceptance Date : June 2, 2020
Publication Date : April 1, 2020

Bibtex @review { jpharmtech741841, journal = {Journal of Pharmaceutical Technology}, issn = {}, eissn = {2717-7904}, address = {Anadolu Üniversitesi Eczacılık Fakültesi Farmasötik Teknoloji Abd Tepebaşı Eskişehir}, publisher = {Mustafa Sinan KAYNAK}, year = {2020}, volume = {1}, pages = {25 - 39}, doi = {10.37662/jpt.2020.4}, title = {Brain-targeted nanoparticles to overcome the blood-brain barrier}, key = {cite}, author = {Seko, Indrit and Şahi̇n, Adem and Tonbul, Hayrettin and Çapan, Yılmaz} }
APA Seko, I , Şahi̇n, A , Tonbul, H , Çapan, Y . (2020). Brain-targeted nanoparticles to overcome the blood-brain barrier . Journal of Pharmaceutical Technology , 1 (1) , 25-39 . DOI: 10.37662/jpt.2020.4
MLA Seko, I , Şahi̇n, A , Tonbul, H , Çapan, Y . "Brain-targeted nanoparticles to overcome the blood-brain barrier" . Journal of Pharmaceutical Technology 1 (2020 ): 25-39 <https://dergipark.org.tr/en/pub/jpharmtech/issue/54396/741841>
Chicago Seko, I , Şahi̇n, A , Tonbul, H , Çapan, Y . "Brain-targeted nanoparticles to overcome the blood-brain barrier". Journal of Pharmaceutical Technology 1 (2020 ): 25-39
RIS TY - JOUR T1 - Brain-targeted nanoparticles to overcome the blood-brain barrier AU - Indrit Seko , Adem Şahi̇n , Hayrettin Tonbul , Yılmaz Çapan Y1 - 2020 PY - 2020 N1 - doi: 10.37662/jpt.2020.4 DO - 10.37662/jpt.2020.4 T2 - Journal of Pharmaceutical Technology JF - Journal JO - JOR SP - 25 EP - 39 VL - 1 IS - 1 SN - -2717-7904 M3 - doi: 10.37662/jpt.2020.4 UR - https://doi.org/10.37662/jpt.2020.4 Y2 - 2020 ER -
EndNote %0 Journal of Pharmaceutical Technology Brain-targeted nanoparticles to overcome the blood-brain barrier %A Indrit Seko , Adem Şahi̇n , Hayrettin Tonbul , Yılmaz Çapan %T Brain-targeted nanoparticles to overcome the blood-brain barrier %D 2020 %J Journal of Pharmaceutical Technology %P -2717-7904 %V 1 %N 1 %R doi: 10.37662/jpt.2020.4 %U 10.37662/jpt.2020.4
ISNAD Seko, Indrit , Şahi̇n, Adem , Tonbul, Hayrettin , Çapan, Yılmaz . "Brain-targeted nanoparticles to overcome the blood-brain barrier". Journal of Pharmaceutical Technology 1 / 1 (April 2020): 25-39 . https://doi.org/10.37662/jpt.2020.4
AMA Seko I , Şahi̇n A , Tonbul H , Çapan Y . Brain-targeted nanoparticles to overcome the blood-brain barrier. J Pharm Technol. 2020; 1(1): 25-39.
Vancouver Seko I , Şahi̇n A , Tonbul H , Çapan Y . Brain-targeted nanoparticles to overcome the blood-brain barrier. Journal of Pharmaceutical Technology. 2020; 1(1): 25-39.