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Development and optimization of antioxidant polyherbal cream using artificial neural network aided response surface methodology

Year 2020, Volume 1, Issue 2, 46 - 53, 01.08.2020
https://doi.org/10.37662/jpt.2020.6

Abstract

Artificial Neural Networks, has become phenomenal in drug modeling, in predicting experimental outcomes and in optimization studies during product development. This research seeks to use artificial neural networks (ANN) to optimize a novel formulation of Polyherbal face cream composed of Cymbopogon citratus, Hibiscus sabdariffa, and Ocimum gratissimum extracts. Central composite design was used to develop a framework for the products to be studied delineating the independent variables to be concentration of oil phase, and that of the emulsifying agents used in formulation. The dependent variables/responses are viscosity, spreadability index, and particle size of the cream. The responses gotten were then optimized using ANN models. The validity of the statistical models used for predicting the observed responses were confirmed by carrying out three confirmation experimental runs at the identified optimum conditions. The viscosity of the formulated cream decreased with increase in the amount of oil phase. However, there was a stronger correlation with amount of emulsifying phase and viscosity of the cream as increased in emulsifier product. The particle sizes did not vary greatly among the various formulations irrespective of the concentration of plant extract. Formulation of Polyherbal face cream composed of Cymbopogon citratus, Hibiscus sabdariffa, and Ocimum gratissimum extracts were shown to have significant antioxidant activity. Using ANN modeling, a prediction of an optimized formulation was made and was shown to have comparable results with the predicted values.

References

  • 1. Ilomuanya MO, Amenaghawon NA, Odimegwu J, Okubanjo OO, Aghaizu C, Oluwatobiloba A. Formulation and optimization of gentamicin hydrogel infused with tetracarpidium conophorum extract via central composite design for topical delivery. Turk J Pharm Sci. (2018); 15(3): 319-327. https://doi.org/10.4274/tjps.33042
  • 2. Edeoga HO, Omosun G, Uche LC. Chemical composition of hyptissuaveolens and ocimum gratissimum hybrids from Nigeria. Afr J Biotechnol. (2006); 5(10): 892-895.
  • 3. Akinmoladun EO, Ibukun AE, Obuotor EM, Farombi EO. Phytochemical constituent and antioxidant activity of extract from the leaves of ocimum gratissimum. Sci Res Essays. (2007); 2(5): 163-166.
  • 4. Chiu YW, Lo HJ, Huang HY, Chao PY, Hwang JM, Huang PY, Lai TJ. The antioxidant and cytoprotective activity of, ocimum gratissimum extracts against hydrogen peroxide-induced toxicity in human HepG2 cells. J Food Drug Anal. (2013); 21(3): 253-260. https://doi.org/10.1016/j.jfda.2013.07.002
  • 5. Ademiluyi AO, Oboh G. Aqueous extracts of roselle (hibiscus sabdariffa Linn.) varieties inhibit α-amylase and α-glucosidase activities in vitro. J Med Food. (2013); 16(1): 88-93. https://doi.org/10.1089/jmf.2012.0004
  • 6. Carmo ES, Pereira F, Cavalcante NM, Gayoso CW, Lima E. Treatment of pityriasis versicolor with topical application of essential oil of cymbopogon citratus (DC) stapf - therapeutic pilot study. An Bras Dermatol. (2013); 88(3): 381-385. https://doi.org/10.1590/abd1806-4841.20131800
  • 7. Amenaghawon NA, Amagbewan E. Evaluating the effect of acid mixtures and solids loading on furfural production from sugarcane bagasse: Optimization using response surface methodology and artificial neural network. RJEES. (2017); 2(2): 578-587.
  • 8. Nath A, Chattopadhyay PK. Optimization of oven toasting for improving crispness and other quality attributes of ready to eat potato- soy snack using response surface methodology. J Food Eng. (2007); 80(4): 1282-1292. https://doi.org/10.1016/j.jfoodeng.2006.09.023
  • 9. Fahimi S, Mortazavi SA, Abdollahi M, Hajimehdipoor H. Formulation of a traditionally used polyherbal product for burn healing and HPTLC fingerprinting of its phenolic contents. Iran J Pharm Res. (2016); 15(1): 95-105.
  • 10. DjiobieTchienou G, TsatsopTsague R, MbamPega T, Bama V, Bamseck A, DongmoSokeng S, Ngassoum M. Multi-response optimization in the formulation of a topical cream from natural ingredients. Cosmetics. (2018); 5(7): 1-14. https://doi.org/10.3390/cosmetics5010007
  • 11. Shen Q, Zhang B, Xu R, Wang Y, Ding X, Li P. Antioxidant activity in vitro of the selenium-contained protein from the Se-enriched Bifidobacterium animalis 01. Anaerobe. (2010); 16 (4): 380-386. https://doi.org/10.1016/j.anaerobe.2010.06.006
  • 12. Ilomuanya MO, Okubanjo OO, Azubuike CP, Oguntibeju A. Evaluation of the frequency of use of herbal drugs with concomitant administration of highly active antiretroviral therapy and its effect on medication adherence in two health care facilities in south western Nigeria. J AIDS HIV Res. (2017); 9(1): 8-16. https://doi.org/10.5897/JAHR2016.0399
  • 13. Ilomuanya MO, Akhimien T, Aghaizu C, Adeyinka O, Ajayi T. Polyherbal antioxidant topical preparation comprising ethanol extract of tetracarpidium conophorum and ocimum gratissimum: Formulation and evaluation. Dhaka Univ J Pharm Sci. (2018); 17(2): 213-219. https://doi.org/10.3329/dujps.v17i2.39178
  • 14. Moldovan M, Lahmar A, Bogdan C, Părăuan S. Formulation and evaluation of a water-in-oil cream containing herbal active ingredients and ferulic acid. Clujul Med. (2017); 90(2): 212-219. https://doi.org/10.15386/cjmed-668
  • 15. Nikovska K. Study of olive oil-in-water emulsions with protein emulsifiers. Emir J Food Agric. (2012); 24: 17-24. https://doi.org/10.9755/ejfa.v24i1.10594
  • 16. Sun C, Gunasekaran S. Effects of protein concentration and oil-phase volume fraction on the stability and rheology of menhaden oil-in- water emulsions stabilized by whey protein isolate with xanthan gum. Food Hydrocoll. (2009); 23(1): 165-174. https://doi.org/10.1016/j.foodhyd.2007.12.006
  • 17. Inoue Y, Suzuki K, Maeda R, Shimura A, Murata I, Kanamoto I. Evaluation of formulation properties and skin penetration in the same additive-containing formulation. Res Pharm Sci. (2014); 4: 42-49. https://doi.org/10.1016/j.rinphs.2014.09.003
  • 18. Dapčević-Hadnađev T, Dokić P, Krstonošić V, Hadnađev M. Influence of oil phase concentration on droplet size distribution and stability of oil-in-water emulsions. Eur J Lipid Sci Technol. (2013); 115(3): 313-321. https://doi.org/10.1002/ejlt.201100321

Year 2020, Volume 1, Issue 2, 46 - 53, 01.08.2020
https://doi.org/10.37662/jpt.2020.6

Abstract

References

  • 1. Ilomuanya MO, Amenaghawon NA, Odimegwu J, Okubanjo OO, Aghaizu C, Oluwatobiloba A. Formulation and optimization of gentamicin hydrogel infused with tetracarpidium conophorum extract via central composite design for topical delivery. Turk J Pharm Sci. (2018); 15(3): 319-327. https://doi.org/10.4274/tjps.33042
  • 2. Edeoga HO, Omosun G, Uche LC. Chemical composition of hyptissuaveolens and ocimum gratissimum hybrids from Nigeria. Afr J Biotechnol. (2006); 5(10): 892-895.
  • 3. Akinmoladun EO, Ibukun AE, Obuotor EM, Farombi EO. Phytochemical constituent and antioxidant activity of extract from the leaves of ocimum gratissimum. Sci Res Essays. (2007); 2(5): 163-166.
  • 4. Chiu YW, Lo HJ, Huang HY, Chao PY, Hwang JM, Huang PY, Lai TJ. The antioxidant and cytoprotective activity of, ocimum gratissimum extracts against hydrogen peroxide-induced toxicity in human HepG2 cells. J Food Drug Anal. (2013); 21(3): 253-260. https://doi.org/10.1016/j.jfda.2013.07.002
  • 5. Ademiluyi AO, Oboh G. Aqueous extracts of roselle (hibiscus sabdariffa Linn.) varieties inhibit α-amylase and α-glucosidase activities in vitro. J Med Food. (2013); 16(1): 88-93. https://doi.org/10.1089/jmf.2012.0004
  • 6. Carmo ES, Pereira F, Cavalcante NM, Gayoso CW, Lima E. Treatment of pityriasis versicolor with topical application of essential oil of cymbopogon citratus (DC) stapf - therapeutic pilot study. An Bras Dermatol. (2013); 88(3): 381-385. https://doi.org/10.1590/abd1806-4841.20131800
  • 7. Amenaghawon NA, Amagbewan E. Evaluating the effect of acid mixtures and solids loading on furfural production from sugarcane bagasse: Optimization using response surface methodology and artificial neural network. RJEES. (2017); 2(2): 578-587.
  • 8. Nath A, Chattopadhyay PK. Optimization of oven toasting for improving crispness and other quality attributes of ready to eat potato- soy snack using response surface methodology. J Food Eng. (2007); 80(4): 1282-1292. https://doi.org/10.1016/j.jfoodeng.2006.09.023
  • 9. Fahimi S, Mortazavi SA, Abdollahi M, Hajimehdipoor H. Formulation of a traditionally used polyherbal product for burn healing and HPTLC fingerprinting of its phenolic contents. Iran J Pharm Res. (2016); 15(1): 95-105.
  • 10. DjiobieTchienou G, TsatsopTsague R, MbamPega T, Bama V, Bamseck A, DongmoSokeng S, Ngassoum M. Multi-response optimization in the formulation of a topical cream from natural ingredients. Cosmetics. (2018); 5(7): 1-14. https://doi.org/10.3390/cosmetics5010007
  • 11. Shen Q, Zhang B, Xu R, Wang Y, Ding X, Li P. Antioxidant activity in vitro of the selenium-contained protein from the Se-enriched Bifidobacterium animalis 01. Anaerobe. (2010); 16 (4): 380-386. https://doi.org/10.1016/j.anaerobe.2010.06.006
  • 12. Ilomuanya MO, Okubanjo OO, Azubuike CP, Oguntibeju A. Evaluation of the frequency of use of herbal drugs with concomitant administration of highly active antiretroviral therapy and its effect on medication adherence in two health care facilities in south western Nigeria. J AIDS HIV Res. (2017); 9(1): 8-16. https://doi.org/10.5897/JAHR2016.0399
  • 13. Ilomuanya MO, Akhimien T, Aghaizu C, Adeyinka O, Ajayi T. Polyherbal antioxidant topical preparation comprising ethanol extract of tetracarpidium conophorum and ocimum gratissimum: Formulation and evaluation. Dhaka Univ J Pharm Sci. (2018); 17(2): 213-219. https://doi.org/10.3329/dujps.v17i2.39178
  • 14. Moldovan M, Lahmar A, Bogdan C, Părăuan S. Formulation and evaluation of a water-in-oil cream containing herbal active ingredients and ferulic acid. Clujul Med. (2017); 90(2): 212-219. https://doi.org/10.15386/cjmed-668
  • 15. Nikovska K. Study of olive oil-in-water emulsions with protein emulsifiers. Emir J Food Agric. (2012); 24: 17-24. https://doi.org/10.9755/ejfa.v24i1.10594
  • 16. Sun C, Gunasekaran S. Effects of protein concentration and oil-phase volume fraction on the stability and rheology of menhaden oil-in- water emulsions stabilized by whey protein isolate with xanthan gum. Food Hydrocoll. (2009); 23(1): 165-174. https://doi.org/10.1016/j.foodhyd.2007.12.006
  • 17. Inoue Y, Suzuki K, Maeda R, Shimura A, Murata I, Kanamoto I. Evaluation of formulation properties and skin penetration in the same additive-containing formulation. Res Pharm Sci. (2014); 4: 42-49. https://doi.org/10.1016/j.rinphs.2014.09.003
  • 18. Dapčević-Hadnađev T, Dokić P, Krstonošić V, Hadnađev M. Influence of oil phase concentration on droplet size distribution and stability of oil-in-water emulsions. Eur J Lipid Sci Technol. (2013); 115(3): 313-321. https://doi.org/10.1002/ejlt.201100321

Details

Primary Language English
Subjects Pharmacology and Pharmacy
Journal Section Research Articles
Authors

Margaret ILOMUANYA> (Primary Author)
University of Lagos
0000-0001-8819-1937
Nigeria


Chukwuebuka ONWUBUYA This is me
Univerisity of Lagos
0000-0000-0000-0000
Nigeria


Andrew AMENAGHAWON This is me
University of Benin
0000-0003-0433-0114
Nigeria

Publication Date August 1, 2020
Submission Date July 20, 2020
Acceptance Date November 28, 2020
Published in Issue Year 2020, Volume 1, Issue 2

Cite

Bibtex @research article { jpharmtech772096, journal = {Journal of Pharmaceutical Technology}, eissn = {2717-7904}, address = {Anadolu Üniversitesi Eczacılık Fakültesi Farmasötik Teknoloji Abd Tepebaşı Eskişehir}, publisher = {Mustafa Sinan KAYNAK}, year = {2020}, volume = {1}, number = {2}, pages = {46 - 53}, doi = {10.37662/jpt.2020.6}, title = {Development and optimization of antioxidant polyherbal cream using artificial neural network aided response surface methodology}, key = {cite}, author = {Ilomuanya, Margaret and Onwubuya, Chukwuebuka and Amenaghawon, Andrew} }
APA Ilomuanya, M. , Onwubuya, C. & Amenaghawon, A. (2020). Development and optimization of antioxidant polyherbal cream using artificial neural network aided response surface methodology . Journal of Pharmaceutical Technology , 1 (2) , 46-53 . DOI: 10.37662/jpt.2020.6
MLA Ilomuanya, M. , Onwubuya, C. , Amenaghawon, A. "Development and optimization of antioxidant polyherbal cream using artificial neural network aided response surface methodology" . Journal of Pharmaceutical Technology 1 (2020 ): 46-53 <https://dergipark.org.tr/en/pub/jpharmtech/issue/54948/772096>
Chicago Ilomuanya, M. , Onwubuya, C. , Amenaghawon, A. "Development and optimization of antioxidant polyherbal cream using artificial neural network aided response surface methodology". Journal of Pharmaceutical Technology 1 (2020 ): 46-53
RIS TY - JOUR T1 - Development and optimization of antioxidant polyherbal cream using artificial neural network aided response surface methodology AU - MargaretIlomuanya, ChukwuebukaOnwubuya, AndrewAmenaghawon Y1 - 2020 PY - 2020 N1 - doi: 10.37662/jpt.2020.6 DO - 10.37662/jpt.2020.6 T2 - Journal of Pharmaceutical Technology JF - Journal JO - JOR SP - 46 EP - 53 VL - 1 IS - 2 SN - -2717-7904 M3 - doi: 10.37662/jpt.2020.6 UR - https://doi.org/10.37662/jpt.2020.6 Y2 - 2020 ER -
EndNote %0 Journal of Pharmaceutical Technology Development and optimization of antioxidant polyherbal cream using artificial neural network aided response surface methodology %A Margaret Ilomuanya , Chukwuebuka Onwubuya , Andrew Amenaghawon %T Development and optimization of antioxidant polyherbal cream using artificial neural network aided response surface methodology %D 2020 %J Journal of Pharmaceutical Technology %P -2717-7904 %V 1 %N 2 %R doi: 10.37662/jpt.2020.6 %U 10.37662/jpt.2020.6
ISNAD Ilomuanya, Margaret , Onwubuya, Chukwuebuka , Amenaghawon, Andrew . "Development and optimization of antioxidant polyherbal cream using artificial neural network aided response surface methodology". Journal of Pharmaceutical Technology 1 / 2 (August 2020): 46-53 . https://doi.org/10.37662/jpt.2020.6
AMA Ilomuanya M. , Onwubuya C. , Amenaghawon A. Development and optimization of antioxidant polyherbal cream using artificial neural network aided response surface methodology. J Pharm Technol. 2020; 1(2): 46-53.
Vancouver Ilomuanya M. , Onwubuya C. , Amenaghawon A. Development and optimization of antioxidant polyherbal cream using artificial neural network aided response surface methodology. Journal of Pharmaceutical Technology. 2020; 1(2): 46-53.
IEEE M. Ilomuanya , C. Onwubuya and A. Amenaghawon , "Development and optimization of antioxidant polyherbal cream using artificial neural network aided response surface methodology", Journal of Pharmaceutical Technology, vol. 1, no. 2, pp. 46-53, Aug. 2020, doi:10.37662/jpt.2020.6

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