Nutritional Substances Affecting The Immune System

Abstract

There are many nutrients that affect animal health and strengthen immunity. Some of these are recognized as additives. Ascorbic acid has a very important function in the immune system, in the synthesis of carnitine and in the use and absorption of other nutrients. β -glucan is a stimulator of the cardiovascular system and immune system. β -glucan has a stimulating effect on macrophages, increasing the cytotoxicity and phagocytic capacity of macrophages. It also shows antioxidant, antiviral, antibacterial, and antifungal activity and has a healing effect on wounds. Inulin is a prebiotic that is isolated from the roots of chicory and yams and is effective on the immune system. It has been determined that prebiotics, which are very difficult to digest under normal conditions, are the food of probiotics. Probiotics affect the immune system with the metabolites they secrete. Another important nutrient for immunity is amino acids. Having sufficient amino acids has a positive effect on immunity. When the minerals required in chemical reactions are at a sufficient level, they have an immune enhancing effect. Studies are carried out on the effects of boron mineral, which has rich deposits in our country, as an additive in animal feeds.

Keywords

• Boron
• ß-glucan
• Immune System
• Minerals
• Prebiotic
• Vitamin

References

1. 1. AYDIN, Ö.D., YILDIZ, G., 2020. The effects of thyme oil and black cumin oil in broiler feeding on growth performance, intestinal histomorphology, and cecal volatile fatty acids. Turk J Vet Anim Sci., 44: 17-25.
2. 2. BHARGAVA, K.K., HANSON, R.P., SUNDE, M.L., 1971. Effects of methionine and valine on growth and antibody production in chicks infected with live or killed Newcastle disease virus. Poult. Sci., 50:614-619.
3. 3. CHEN, J., SEVIOUR, R., 2007. Medicinal importance of fungal β-(1-- >3), (1-->6)-glucans. Mycol Res., 111:635-52.
4. 4. CHENG, Y.H., LEE, D.N., WEN, C.M., WENG, C.F., 2004. Effects of β-glucan supplementation on lymphocyte proliferation, macrophage chemotaxis and specific immune responses in broilers. Asian Austral. J. Anim., 17: 1145-1149.
5. 5. ELRAYEH, A.S., YILDIZ, G., 2012. Effects of inulin and β-glucan supplementation in broiler diets on growth performance, serum cholesterol, intestinal length, and immune system. Turk. J. Vet. Anim. Sci., 36(4): 388-394
6. 6. ENGSTAD, R.E., ROBERTSEN, B., 1994. Specificity of a ß-glucan receptor on macrophages from Atlantic salmon (Salmo salar L.). Developmental Comparative Immunol., 18: 397-408.
7. 7. JAMROZ, D., KAMEL, C., 2002. Plant extracts enhance broiler performance. In non ruminant nutrition: Antimicrobial agents and plant extracts on immunity, healt and performance. J. Anim. Sci., 80 (E.suppl 1), 41.
8. 8. KAPLAN, M., YILDIZ, G., 2017. The effects of dietary supplementation levels of valineon performance and immune System of broiler chickens Journal of Agricultural and Crop Research, 5:25-31.

9. 9. KARABAYIR, N., GÖKÇAY, G., 2006. Vitamin C. Türkiye Klinikleri J Pediatr Sci., 2:37-41.
10. 10. KARASU, K., ÖZTÜRK, E., 2014. Tıbbi ve Aromatik Bitkilerin Kanatlılarda Antioksidan ve Antimikrobiyal Etkileri. Turkish Journal of Agricultural and Natural Sciences, Special Issue, 2:1766-1772
11. 11. KHALAFALLA, M.M.E., 2009. Utilization of some med oreochromis niloticus ical plants as feed additives for Nile Tilapia, Oreochromis Niloticus, Feeds. Mediterranean Aquaculture Journal, 2(1): 9-18.
12. 12. KITANDU, A., JURANOVA, R., 2006. Progress in control measures for chicken coccidiosis. Actavet Brno, 265-276.
13. 13. KRAKOWSKI, L., KRZYZANNOWSKI, J., WRONA, Z., SIWICKI, A.K., 1999. The effect of nonspecific immunositimulation of pregnant mares with 1,3/1,6 glucan and levamisol on the immunoglobulins levels in collostrum, selected incidences of nonspecific cellular and humoral immunity in foals in neonatal and postnatal period. Vet. Immunol. and Immunopathol., 68:1-11.
14. 14. KURTOĞLU, V., KURTOĞLU, F., COŞKUN, B., ŞEKER, E., BALEVI, T., CETINGÜL, I.S., 2002. Effects of Boron supplementation on Performance and some Serum Biochemical Parameters in Laying Hens. Rev. Med. Vet. – Toulous, 153: 823-828.
15. 15. LEE, K-W., EVERTS, H., BEYNEN, A.C., 2004. Essential oils in broiler nutrition. Int. J. Poultry Sci., 3(12): 738-752.
16. 16. LEVINE, M., 1986. New Concepts in the Biology and Biochemistry of Ascorbic Acid. N. Eng. J. Med., 3:892-902.
17. 17. MANSELL, P.W.A., 1986. Employment of soluble glucan in the treatment of patients with Acquired Immunodeficiency Syndrome. M.D Anderson Cancer Center, IND., 1986.
18. 18. NIITTYNEN, L., KAJANDER, K., KORPELA, R.. 2007. Galacto-oligosaccharides and bowel function. Scand J Food Nutr., 51:62.
19. 19. NINESS, K.R., 1999. Inulin and oligofructose: What are they? J. Nutr., 129: 1402–1406.
20. 20. PRICE, G.B., MAKINODAN, T., 1972. Immunologic deficiencies in senescence. The Journal of Immunology, 108:403-412.
21. 21. SABATER-MOLINA, M., LARQUE, E., TORRELLA, F., ZAMORA, S., 2009. Dietary fructooligosaccharides and potential benefits on health. J Physiol Biochem., 65:315–328.
22. 22. SAÇAKLI, P., 2019. Mineraller ve bağışıklık ilişkisi. Demirel G (ed), Hayvanlarda Beslenme ve Bağışıklık İlişkisi. 1. Baskı. Ankara: Türkiye Klinikleri, 35-41.
23. 23. SAINI, R., DAVIS, S., DUDLEY- CASH, W., 2004. Oregano essential oil reduces the expression of coccidiosis in broiler. 22. World Poultry Congress book of abstracts. s: 583.
24. 24. SIZMAZ, O., YILDIZ, G., 2014. Effects of single or combined dietary supplementation of boric acid and ascorbic acid on growth performance, bone mineralization and cholesterolemia in broilers. Inter J Agri Biosci., 3(5): 214-218.
25. 25. SRINIVASJOIS, R., RAO, S., PATOLE, S., 2009. Prebiotic supplementation of formula in preterm neonates: a systematic review and meta-analysis of randomized controlled trials. Clin Nutr., 28:237–242.
26. 26. SYNLAB, 2018. C Vitamini. Erişim Adresi: https://www.synlab.com.tr/ fileadmin/standortseiten/synlab_tr/pdf/SYNLAB_VITAMIN_C__ASKORBIK_ASIT_.pdf Erişim Tarihi: 20.08.2020.
27. 27. THORNTON, S.A., CORZO, G.T., PHARR, W.A., DOZIER, III, MILES, D.M., KIDD, M.T., 2006. Valine requirements for immune and growth responses in broilers from 3 to 6 weeks of age. Br. Poult. Sci., 47:190-199.
28. 28. TONSY, H.D., MAHMOUD, S.H., LABIB, E.H., ZAKI, M.A., 2011. Effect of some medicinal plants diets on the mono-sex Nile Tilapia (Oreochromis niloticus), growth performance, feed utilization and some physiological parameters. Egypt J. Aquat. Biol. & Fish., 15(2): 53-72.
29. 29. TURAN F, GÜRAĞAÇ R, SAYIN S. 2012. Su Ürünleri Yetiştiriciliğinde Esansiyel Yağlar. Türk Bilimsel Derlemeler Dergisi, 5(1): 35-40.
30. 30. VETVICKA, V., 2003. Beta Glukan. Immuneks Toplantı Programı. Atatürk Kültür Merkezi, İzmir.
31. 31. VIEIRA, S.L., BERRES, J., REIS, R.N., OYARZABAL, O.A., CONEGLIAN, J.L.B., FREITAS, D.M., PENA, J.E.M., TORRES, C.A., 2008. Studies with sanguinarine like alkaloids as feed additive in broiler diets. Brazilian Journal of Poultry Science, 10: 67-71.
32. 32. WATZL, B., GIRRBACH, S., ROLLER, M., 2005. Inulin, oligofructose and immunomodulation. Brit. J. Nutr. 93: 49–55.
33. 33. WEI, D., ZHANG, L., WILLIAMS, D.L., BROWDER, I.W., 2002. Glucan stimulates human dermal fibroblast collagen biosynthesis through a nuclear factor-1 dependent mechanism. Wound Repair Regen; 10: 161-168.
34. 34. WYDE, P., 1989. NSC-24™: Research report on oral and intraperitoneal applications in mice. ImmuDyne, Inc.
35. 35. YARSAN, E., GÜLEÇ, M., 2003. Kanatlılarda Stres, Vitamin ve Mineral Uygulamaları. Türk Veteriner Hekimleri Birliği Dergisi. 55-63.
36. 36. YEŞİLBAĞ, D., EREN, M., 2008. Yaşlı Yumurta Tavuğu Rasyonlarında Borik Asit Kullanımı. 2. Ulusal Bor Çalıştayı Bildirileri Kitabı, 17-18 Nisan 2008, Ankara. 613-618.
37. 37. YILDIZ, G., ABACIOĞLU, Ö., 2007. Sağlık ve Hayvan Besleme Açısından Bor. IV. Ulusal Hayvan Besleme Kongresi, 24-28 Haziran 2007, Bursa. 481-487.
38. 38. YILDIZ, Y., SACAKLI, P., GUNGOR, T.. 2006. The effect of dietary Jerusalem artichoke (Helianthus tuberosus L.) on performance, egg quality characteristics and egg cholesterol content in laying hens. Czech J. Anim. Sci., 51(8): 349–354.