Research Article
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Year 2024, Volume: 28 Issue: 6, 1953 - 1962, 28.06.2025
https://doi.org/10.29228/jrp.868

Abstract

References

  • [1] Chen B, Li R, Yan N, Chen G, Qian W, Jiang HL, Ji C, Bi ZG. Astragaloside IV controls collagen reduction in photoaging skin by improving transforming growth factor-β/Smad signaling suppression and inhibiting matrix metalloproteinase-1. Mol Med Rep. 2015; 11(5):3344–3348. https://doi.org/10.3892%2Fmmr.2015.3212
  • [2] Ham SA, Yoo T, Hwang JS, Kang ES, Paek KS, Park C, Kim JH, Do JT, Seo HG. Peroxisome Proliferator-Activated Receptor δ modulates MMP-2 secretion and elastin expression in human dermal fibroblasts exposed to Ultraviolet B Radiation. J Dermatol Sci. 2014; 76(1):44–50. https://doi.org/10.1016/j.jdermsci.2014.07.011
  • [3] Darsika C, Sowmya KV, Suganya K, Grace FX. Preparation and evaluation of herbal peel off face mask. Am J PharmTech Res. 2015; 5(4):33–336.
  • [4] Yaar M, Gilchrest BA. Photoageing: Mechanism, prevention, and therapy. Br J Dermatol. 2007; 157(5):874–887. https://doi.org/10.1111/j.1365-2133.2007.08108.x
  • [5] DeNaverre MG. The chemistry and manufacture of cosmetics. 2nd ed. Orlando: Continental; 1975.
  • [6] Baby AR, Zague V, Maciel CPM, Kaneko TM, Consiglieri VO, Valesco MVR. Development of cosmetic mask formulations. Rev Bras Ciênc Farm. 2004; 240:159–161. https://doi.org/10.1590/S1984-82502009000300018
  • [7] Beringhs A, Rosa J, Stulzer H, Budal R, Sonaglio D. Green clay and aloe vera peel-off facial masks: Response surface methodology applied to the formulation design. AAPS Pharm Sci Tech. 2013; 14(1):444-455. https://doi.org/10.1208%2Fs12249-013-9930-8
  • [8] Garg A, Aggarwal D, Garg S, dan Singla AK. Spreading of semisolid formulations. Pharm Techn. 2002; 26:84–105.
  • [9] Abbasi S, Farzanmehr H. Optimization of the formulation of prebiotic milk chocolate based on rheological properties. Food Sci Biotechnol. 2009; 47:396–403.
  • [10] Aidoo RP, Afoakwa EO, and Dewettinck K. Optimization of inulin and polydextrose mixtures as sucrose replacers during sugar–free chocolate manufacture rheological, microstructure and physical quality characteristics. J Food Eng. 2014; 126:35–42. http://dx.doi.org/10.1016/j.jfoodeng.2013.10.036
  • [11] Mazumder MAJ, Sheardown H, Al-Ahmed A. Functional Polymers, Polymers, and Polymeric Composites: A Reference Series. Springer International Publishing AG, part of Springer Nature; 2018.
  • [12] Rowe RC, Sheskey PJ, Quinn ME. Handbook of Pharmaceutical Excipients (Sixth). Pharmaceutical Press; 2009.
  • [13] Kong D, Zhang Q, You J, Cheng Y, Hong C, Chen Z, Jiang T, Hao T. Adhesion loss mechanism based on carboxymethyl cellulose-filled hydrocolloid dressings in physiological wounds environment. Carbohydr Polym. 2020; 235:115953. https://doi.org/10.1016/j.carbpol.2020.115953
  • [14] Tariq Z, Iqbal DN, Rizwan M, Ahmad M, Faheem M, Ahmed M. Significance of biopolymer-based hydrogels and their applications in agriculture: A review in perspective of synthesis and their degree of swelling for water holding. RSC Adv. 2023; 13:24731. https://doi.org/10.1039/D3RA03472K
  • [15] Mansur AAP, Rodrigues MA, Capanema NSV, Carvalho SM, Gomesb DA, Mansur HS. Functionalized bio adhesion-enhanced carboxymethyl cellulose/polyvinyl alcohol hybrid hydrogels for chronic wound dressing applications. RSC Adv. 2023; 13:13156. https://doi.org/10.1039/D3RA01519J
  • [16] Chang HJ, Rodríguez‐Pérez IA, Fayette M, Canfield NL, Pan H, Choi D, Li X, Reed D. Effects of water‐based binders on electrochemical performance of manganese dioxide cathode in mild aqueous zinc batteries. Carbon Energy. 2021; 3:473–481. http://dx.doi.org/10.1002/cey2.84
  • [17] Stan D, Codrici E, Enciu A, Olewnik-Kruszkowska E, Gavril G, Ruta LL, Moldovan C, Brincoveanu O, Bocancia Mateescu L, Mirica A, Stan D, Tanase C. Exploring the impact of alginate—PVA ratio and the addition of bioactive substances on the performance of hybrid hydrogel membranes as potential wound dressings. Gels. 2023; 9:476. https://doi.org/10.3390/gels9060476
  • [18] Kim JO, Park JK, Kim JH, Jin SG, Yong CS, Li DX, Choi JY, Woo JS, Yoo BK, Lyoo WS, Kim J, and Choi H. Development of polyvinyl alcohol-sodium alginate gel-matrix-based wound dressing system containing nitrofurazone. Int J Pharm. 2008; 359: 79. https://doi.org/10.1016/j.ijpharm.2008.03.021
  • [19] Bochek AM, Yusupova LD, Zabivalova NM, and Petrapoviovskii GA. Rheological properties of aqueous H carboxymethyl cellulose solutions with various additives. Russ J Appl Chem. 2002; 75: 4–5. http://dx.doi.org/10.1023/A:1019585618374
  • [20] Allen LV. The art and technologi of pharmaceutical compounding. American Pharmaceutical Association, Whashington DC, 1998, pp. 322-323.
  • [21] Cheryl L, Dikeman, Michael R, Murphy, Fahey Jr GC. Dietary fibers affect viscosity of solutions and simulated human gastric and small intestinal digesta. J Nutr. 2006; 136 (4):913-919. https://doi.org/10.1093/jn/136.4.913
  • [22] Wibbeke A, Schöeppner V, Mahnken R. Experimental Investigations on the induced anisotropy of mechanical properties in polycarbonate films. ISRN Mater Sci. 2013; 649043:8. https://doi.org/10.1155/2013/649043

Optimization of peel-off gel mask formula containing Binahong (Anredera cordifolia) leaf extract based PVA CMC- alginate combination

Year 2024, Volume: 28 Issue: 6, 1953 - 1962, 28.06.2025
https://doi.org/10.29228/jrp.868

Abstract

Facial masks are often used for the prevention of skin damage, such as skin aging due to free radical activity. The peel-off gel mask is convenient because it can be easily removed after drying without rinsing. Free radical activity can be inhibited by using antioxidants. One of the antioxidants can be derived from natural materials such as binahong. This study aimed to optimize the peel-off gel mask formula containing binahong leaf extract and evaluate the antioxidant activity of the gel mask formula during the storage period. Peel-off gel masks were prepared by combining PVA, CMC-Na, and sodium alginate as gelling agents. A simplex lattice design (SLD) method was used to optimize the peel-off gel mask formula. The optimum formulation was obtained using a combination of 3.5 g PVA, 1.5 g sodium alginate, 5 g propylene glycol, and 0.1 g potassium sorbate. The optimum formulation has an average spreading capacity of 9.2 ± 0.21 cm, adhesion capacity of 1.09 ± 0.33 seconds, viscosity level of 1491.67 ± 10.78 cP, pH of 7.21 ± 0.02, a drying time of 68 ± 6.24 min, tensile strength of 1.792 ± 0.25 MPa, elongation of 68.077% ± 1.14, and antioxidant capacity with inhibition percentage of 55.087% ± 2.87. The peel-off gel mask containing binahong leaf extract meets the good criteria as the peel-off gel mask. Moreover, the characteristics of the optimal formula peel-off gel mask did not change significantly for 4 weeks of storage at 40oC ± 2oC/75%RH ± 5%RH.

References

  • [1] Chen B, Li R, Yan N, Chen G, Qian W, Jiang HL, Ji C, Bi ZG. Astragaloside IV controls collagen reduction in photoaging skin by improving transforming growth factor-β/Smad signaling suppression and inhibiting matrix metalloproteinase-1. Mol Med Rep. 2015; 11(5):3344–3348. https://doi.org/10.3892%2Fmmr.2015.3212
  • [2] Ham SA, Yoo T, Hwang JS, Kang ES, Paek KS, Park C, Kim JH, Do JT, Seo HG. Peroxisome Proliferator-Activated Receptor δ modulates MMP-2 secretion and elastin expression in human dermal fibroblasts exposed to Ultraviolet B Radiation. J Dermatol Sci. 2014; 76(1):44–50. https://doi.org/10.1016/j.jdermsci.2014.07.011
  • [3] Darsika C, Sowmya KV, Suganya K, Grace FX. Preparation and evaluation of herbal peel off face mask. Am J PharmTech Res. 2015; 5(4):33–336.
  • [4] Yaar M, Gilchrest BA. Photoageing: Mechanism, prevention, and therapy. Br J Dermatol. 2007; 157(5):874–887. https://doi.org/10.1111/j.1365-2133.2007.08108.x
  • [5] DeNaverre MG. The chemistry and manufacture of cosmetics. 2nd ed. Orlando: Continental; 1975.
  • [6] Baby AR, Zague V, Maciel CPM, Kaneko TM, Consiglieri VO, Valesco MVR. Development of cosmetic mask formulations. Rev Bras Ciênc Farm. 2004; 240:159–161. https://doi.org/10.1590/S1984-82502009000300018
  • [7] Beringhs A, Rosa J, Stulzer H, Budal R, Sonaglio D. Green clay and aloe vera peel-off facial masks: Response surface methodology applied to the formulation design. AAPS Pharm Sci Tech. 2013; 14(1):444-455. https://doi.org/10.1208%2Fs12249-013-9930-8
  • [8] Garg A, Aggarwal D, Garg S, dan Singla AK. Spreading of semisolid formulations. Pharm Techn. 2002; 26:84–105.
  • [9] Abbasi S, Farzanmehr H. Optimization of the formulation of prebiotic milk chocolate based on rheological properties. Food Sci Biotechnol. 2009; 47:396–403.
  • [10] Aidoo RP, Afoakwa EO, and Dewettinck K. Optimization of inulin and polydextrose mixtures as sucrose replacers during sugar–free chocolate manufacture rheological, microstructure and physical quality characteristics. J Food Eng. 2014; 126:35–42. http://dx.doi.org/10.1016/j.jfoodeng.2013.10.036
  • [11] Mazumder MAJ, Sheardown H, Al-Ahmed A. Functional Polymers, Polymers, and Polymeric Composites: A Reference Series. Springer International Publishing AG, part of Springer Nature; 2018.
  • [12] Rowe RC, Sheskey PJ, Quinn ME. Handbook of Pharmaceutical Excipients (Sixth). Pharmaceutical Press; 2009.
  • [13] Kong D, Zhang Q, You J, Cheng Y, Hong C, Chen Z, Jiang T, Hao T. Adhesion loss mechanism based on carboxymethyl cellulose-filled hydrocolloid dressings in physiological wounds environment. Carbohydr Polym. 2020; 235:115953. https://doi.org/10.1016/j.carbpol.2020.115953
  • [14] Tariq Z, Iqbal DN, Rizwan M, Ahmad M, Faheem M, Ahmed M. Significance of biopolymer-based hydrogels and their applications in agriculture: A review in perspective of synthesis and their degree of swelling for water holding. RSC Adv. 2023; 13:24731. https://doi.org/10.1039/D3RA03472K
  • [15] Mansur AAP, Rodrigues MA, Capanema NSV, Carvalho SM, Gomesb DA, Mansur HS. Functionalized bio adhesion-enhanced carboxymethyl cellulose/polyvinyl alcohol hybrid hydrogels for chronic wound dressing applications. RSC Adv. 2023; 13:13156. https://doi.org/10.1039/D3RA01519J
  • [16] Chang HJ, Rodríguez‐Pérez IA, Fayette M, Canfield NL, Pan H, Choi D, Li X, Reed D. Effects of water‐based binders on electrochemical performance of manganese dioxide cathode in mild aqueous zinc batteries. Carbon Energy. 2021; 3:473–481. http://dx.doi.org/10.1002/cey2.84
  • [17] Stan D, Codrici E, Enciu A, Olewnik-Kruszkowska E, Gavril G, Ruta LL, Moldovan C, Brincoveanu O, Bocancia Mateescu L, Mirica A, Stan D, Tanase C. Exploring the impact of alginate—PVA ratio and the addition of bioactive substances on the performance of hybrid hydrogel membranes as potential wound dressings. Gels. 2023; 9:476. https://doi.org/10.3390/gels9060476
  • [18] Kim JO, Park JK, Kim JH, Jin SG, Yong CS, Li DX, Choi JY, Woo JS, Yoo BK, Lyoo WS, Kim J, and Choi H. Development of polyvinyl alcohol-sodium alginate gel-matrix-based wound dressing system containing nitrofurazone. Int J Pharm. 2008; 359: 79. https://doi.org/10.1016/j.ijpharm.2008.03.021
  • [19] Bochek AM, Yusupova LD, Zabivalova NM, and Petrapoviovskii GA. Rheological properties of aqueous H carboxymethyl cellulose solutions with various additives. Russ J Appl Chem. 2002; 75: 4–5. http://dx.doi.org/10.1023/A:1019585618374
  • [20] Allen LV. The art and technologi of pharmaceutical compounding. American Pharmaceutical Association, Whashington DC, 1998, pp. 322-323.
  • [21] Cheryl L, Dikeman, Michael R, Murphy, Fahey Jr GC. Dietary fibers affect viscosity of solutions and simulated human gastric and small intestinal digesta. J Nutr. 2006; 136 (4):913-919. https://doi.org/10.1093/jn/136.4.913
  • [22] Wibbeke A, Schöeppner V, Mahnken R. Experimental Investigations on the induced anisotropy of mechanical properties in polycarbonate films. ISRN Mater Sci. 2013; 649043:8. https://doi.org/10.1155/2013/649043
There are 22 citations in total.

Details

Primary Language English
Subjects Pharmaceutical Delivery Technologies
Journal Section Research Article
Authors

Listia Ayu Winingrum This is me 0009-0008-9630-5453

Khadijah Zai 0000-0003-4447-6177

Submission Date November 10, 2023
Acceptance Date February 26, 2024
Publication Date June 28, 2025
Published in Issue Year 2024 Volume: 28 Issue: 6

Cite

APA Winingrum, L. A., & Zai, K. (2025). Optimization of peel-off gel mask formula containing Binahong (Anredera cordifolia) leaf extract based PVA CMC- alginate combination. Journal of Research in Pharmacy, 28(6), 1953-1962. https://doi.org/10.29228/jrp.868
AMA Winingrum LA, Zai K. Optimization of peel-off gel mask formula containing Binahong (Anredera cordifolia) leaf extract based PVA CMC- alginate combination. J. Res. Pharm. July 2025;28(6):1953-1962. doi:10.29228/jrp.868
Chicago Winingrum, Listia Ayu, and Khadijah Zai. “Optimization of Peel-off Gel Mask Formula Containing Binahong (Anredera Cordifolia) Leaf Extract Based PVA CMC- Alginate Combination”. Journal of Research in Pharmacy 28, no. 6 (July 2025): 1953-62. https://doi.org/10.29228/jrp.868.
EndNote Winingrum LA, Zai K (July 1, 2025) Optimization of peel-off gel mask formula containing Binahong (Anredera cordifolia) leaf extract based PVA CMC- alginate combination. Journal of Research in Pharmacy 28 6 1953–1962.
IEEE L. A. Winingrum and K. Zai, “Optimization of peel-off gel mask formula containing Binahong (Anredera cordifolia) leaf extract based PVA CMC- alginate combination”, J. Res. Pharm., vol. 28, no. 6, pp. 1953–1962, 2025, doi: 10.29228/jrp.868.
ISNAD Winingrum, Listia Ayu - Zai, Khadijah. “Optimization of Peel-off Gel Mask Formula Containing Binahong (Anredera Cordifolia) Leaf Extract Based PVA CMC- Alginate Combination”. Journal of Research in Pharmacy 28/6 (July2025), 1953-1962. https://doi.org/10.29228/jrp.868.
JAMA Winingrum LA, Zai K. Optimization of peel-off gel mask formula containing Binahong (Anredera cordifolia) leaf extract based PVA CMC- alginate combination. J. Res. Pharm. 2025;28:1953–1962.
MLA Winingrum, Listia Ayu and Khadijah Zai. “Optimization of Peel-off Gel Mask Formula Containing Binahong (Anredera Cordifolia) Leaf Extract Based PVA CMC- Alginate Combination”. Journal of Research in Pharmacy, vol. 28, no. 6, 2025, pp. 1953-62, doi:10.29228/jrp.868.
Vancouver Winingrum LA, Zai K. Optimization of peel-off gel mask formula containing Binahong (Anredera cordifolia) leaf extract based PVA CMC- alginate combination. J. Res. Pharm. 2025;28(6):1953-62.