Interplay of Extended Clearance and Salivary Excretion Classification Systems

Abstract

The aim of this commentary is to investigate the interplay of Extended Clearance Classification System (ECCS) and Salivary Excretion Classification System (SECS). ECCS utilized the involvement of transporters to classify drugs based on permeability, ionization and molecular weight for the purpose of predicting rate determining clearance. On the other hand, SECS classified drugs based on permeability and protein binding for the purpose of predicting salivary excretion of drugs. Conclusion: The proposed Salivary Excretion Classification System (SECS) can be used as a guide for drug salivary excretion based on permeability and protein binding, but not transporters involved.

Keywords

• EECS
• SECS
• BCS
• ADMIT predictor
• transporters

References

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