Encountering the potentials of probiotics against urogenital tract infections in females

Zainab Abdullah Khaleel; Zahraa Amer Hashim; Vildan Celiksoy

doi:10.12991/jrespharm.1667840

Encountering the potentials of probiotics against urogenital tract infections in females

Abstract

Urinary tract infection (UTI) and vaginitis are common conditions among females, significantly impacting overall life health and quality, imposing economical burdens and rising concerns of antibiotic resistance and limiting current treatments, probiotics have emerged as promising non antibiotic adjuvant and alternatives. Lactobacillus species restore and sustain a balanced microbiome offering protection against uro-pathogens by enhancement of epithelium barrier, immune modulation, competitive exclusions and biofilm disruptions. Clinical trials have documented the efficacy of probiotics both orally and vaginally in reducing UTI, preventing recurrences and restoring vaginal microbiota. This review highlights the aspects of probiotics mechanism of action, clinical trials and applications, exploring potentials of next generation probiotics and advancement in in delivery systems. While probiotics offer promising efficacy in managing UTI and vaginitis, further research studies are required to clarify exact mechanisms, strains potentials, dosage forms and doses, framing regulations regarding probiotics industry and tailored probiotics field.

Keywords

Supporting Institution

none

Project Number

Not applicable

Ethical Statement

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References

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Details

Primary Language

English

Subjects

Pharmaceutical Microbiology

Journal Section

Review

Authors

Zainab Abdullah Khaleel This is me
0009-0003-9877-410X
Iraq

Zahraa Amer Hashim ^*
0000-0002-0635-5772
Iraq

Vildan Celiksoy This is me
0000-0002-9261-7053
United Kingdom

Publication Date

January 11, 2026

Submission Date

April 2, 2025

Acceptance Date

May 17, 2025

Published in Issue

Year 2026 Volume: 30 Number: 1

DOI

https://doi.org/10.12991/jrespharm.1667840

IZ

https://izlik.org/JA95KG82XZ

Cite

RIS / Bibtex

APA

Abdullah Khaleel, Z., Amer Hashim, Z., & Celiksoy, V. (2026). Encountering the potentials of probiotics against urogenital tract infections in females. Journal of Research in Pharmacy, 30(1), 246-262. https://doi.org/10.12991/jrespharm.1667840

AMA

1.Abdullah Khaleel Z, Amer Hashim Z, Celiksoy V. Encountering the potentials of probiotics against urogenital tract infections in females. J. Res. Pharm. 2026;30(1):246-262. doi:10.12991/jrespharm.1667840

Chicago

Abdullah Khaleel, Zainab, Zahraa Amer Hashim, and Vildan Celiksoy. 2026. “Encountering the Potentials of Probiotics Against Urogenital Tract Infections in Females”. Journal of Research in Pharmacy 30 (1): 246-62. https://doi.org/10.12991/jrespharm.1667840.

EndNote

Abdullah Khaleel Z, Amer Hashim Z, Celiksoy V (January 1, 2026) Encountering the potentials of probiotics against urogenital tract infections in females. Journal of Research in Pharmacy 30 1 246–262.

IEEE

[1]Z. Abdullah Khaleel, Z. Amer Hashim, and V. Celiksoy, “Encountering the potentials of probiotics against urogenital tract infections in females”, J. Res. Pharm., vol. 30, no. 1, pp. 246–262, Jan. 2026, doi: 10.12991/jrespharm.1667840.

ISNAD

Abdullah Khaleel, Zainab - Amer Hashim, Zahraa - Celiksoy, Vildan. “Encountering the Potentials of Probiotics Against Urogenital Tract Infections in Females”. Journal of Research in Pharmacy 30/1 (January 1, 2026): 246-262. https://doi.org/10.12991/jrespharm.1667840.

JAMA

1.Abdullah Khaleel Z, Amer Hashim Z, Celiksoy V. Encountering the potentials of probiotics against urogenital tract infections in females. J. Res. Pharm. 2026;30:246–262.

MLA

Abdullah Khaleel, Zainab, et al. “Encountering the Potentials of Probiotics Against Urogenital Tract Infections in Females”. Journal of Research in Pharmacy, vol. 30, no. 1, Jan. 2026, pp. 246-62, doi:10.12991/jrespharm.1667840.

Vancouver

1.Zainab Abdullah Khaleel, Zahraa Amer Hashim, Vildan Celiksoy. Encountering the potentials of probiotics against urogenital tract infections in females. J. Res. Pharm. 2026 Jan. 1;30(1):246-62. doi:10.12991/jrespharm.1667840