In vitro antioxidant and cytotoxic activity of Muscari neglectum growing in Turkey

Esra Eroğlu Özkan; Serpil Demirci Kayıran; Turgut Taşkın; Mahmoud Abudayyak [m. F. Kenanoğlu]

In vitro antioxidant and cytotoxic activity of Muscari neglectum growing in Turkey

Abstract

Muscari species have been used as antirheumatic, stomachic, diuretic, expectorant and anti verruca in folk medicine. The species have also been used as food for humans and animals in Turkey. In this study, the antioxidant and cytotoxic activities of different extracts obtained from Muscari neglectum were studied. The antioxidant capacities of the extracts were evaluated with DPPH free radical scavenging activity, metal chelating capacity and ABTS cation radical scavenging capacity assays. The cytotoxic potentials of the extracts were determined by MTT and LDH assays on HeLa-cells (human cancer cell line) and NRK-52E-cells (rat kidney cell line). The aqueous extracts from M. neglectum bulbs (IC50: 2.83± 0.54 mg/mL) and herba (IC50: 8.52± 1.3 mg/mL) exhibited stronger DPPH free radical scavenging activity than other extracts, respectively. The ethanol extract from M. neglectum bulbs showed the highest ABTS (27.88 %) cation radical scavenging activity. According to the metal chelating activity test results, the aqueous extracts from M. neglectum herba and bulbs showed the strongest metal chelating activity (28.99% and 28.07%, respectively)

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacognosy, Pharmaceutical Botany

Journal Section

Research Article

Authors

Esra Eroğlu Özkan ^*
0000-0002-1569-2535
Türkiye

Serpil Demirci Kayıran
0000-0001-8340-3347
Türkiye

Turgut Taşkın
0000-0001-8475-6478
Türkiye

Mahmoud Abudayyak [m. F. Kenanoğlu]
0000-0003-2286-4777
Türkiye

Publication Date

June 27, 2025

Submission Date

September 19, 2017

Acceptance Date

November 29, 2017

Published in Issue

Year 2018 Volume: 22 Number: 1

IZ

https://izlik.org/JA35CD69CX

Cite

RIS / Bibtex

APA

Eroğlu Özkan, E., Demirci Kayıran, S., Taşkın, T., & Abudayyak [m. F. Kenanoğlu], M. (2025). In vitro antioxidant and cytotoxic activity of Muscari neglectum growing in Turkey. Journal of Research in Pharmacy, 22(1), 74-79. https://izlik.org/JA35CD69CX

AMA

1.Eroğlu Özkan E, Demirci Kayıran S, Taşkın T, Abudayyak [m. F. Kenanoğlu] M. In vitro antioxidant and cytotoxic activity of Muscari neglectum growing in Turkey. J. Res. Pharm. 2025;22(1):74-79. https://izlik.org/JA35CD69CX

Chicago

Eroğlu Özkan, Esra, Serpil Demirci Kayıran, Turgut Taşkın, and Mahmoud Abudayyak [m. F. Kenanoğlu]. 2025. “In Vitro Antioxidant and Cytotoxic Activity of Muscari Neglectum Growing in Turkey”. Journal of Research in Pharmacy 22 (1): 74-79. https://izlik.org/JA35CD69CX.

EndNote

Eroğlu Özkan E, Demirci Kayıran S, Taşkın T, Abudayyak [m. F. Kenanoğlu] M (June 1, 2025) In vitro antioxidant and cytotoxic activity of Muscari neglectum growing in Turkey. Journal of Research in Pharmacy 22 1 74–79.

IEEE

[1]E. Eroğlu Özkan, S. Demirci Kayıran, T. Taşkın, and M. Abudayyak [m. F. Kenanoğlu], “In vitro antioxidant and cytotoxic activity of Muscari neglectum growing in Turkey”, J. Res. Pharm., vol. 22, no. 1, pp. 74–79, June 2025, [Online]. Available: https://izlik.org/JA35CD69CX

ISNAD

Eroğlu Özkan, Esra - Demirci Kayıran, Serpil - Taşkın, Turgut - Abudayyak [m. F. Kenanoğlu], Mahmoud. “In Vitro Antioxidant and Cytotoxic Activity of Muscari Neglectum Growing in Turkey”. Journal of Research in Pharmacy 22/1 (June 1, 2025): 74-79. https://izlik.org/JA35CD69CX.

JAMA

1.Eroğlu Özkan E, Demirci Kayıran S, Taşkın T, Abudayyak [m. F. Kenanoğlu] M. In vitro antioxidant and cytotoxic activity of Muscari neglectum growing in Turkey. J. Res. Pharm. 2025;22:74–79.

MLA

Eroğlu Özkan, Esra, et al. “In Vitro Antioxidant and Cytotoxic Activity of Muscari Neglectum Growing in Turkey”. Journal of Research in Pharmacy, vol. 22, no. 1, June 2025, pp. 74-79, https://izlik.org/JA35CD69CX.

Vancouver

1.Esra Eroğlu Özkan, Serpil Demirci Kayıran, Turgut Taşkın, Mahmoud Abudayyak [m. F. Kenanoğlu]. In vitro antioxidant and cytotoxic activity of Muscari neglectum growing in Turkey. J. Res. Pharm. [Internet]. 2025 Jun. 1;22(1):74-9. Available from: https://izlik.org/JA35CD69CX