Potential protective effects of silk fibroin against ethanol induced gastric ulcer

Aslı Aykaç; Buse Karanlık; Ahmet Özer Şehirli

Potential protective effects of silk fibroin against ethanol induced gastric ulcer

Abstract

Ulcers that develop due to alcohol consumption are frequently confronted. The aim of this study was to investigate the protective effects of silk fibroin on the pro-apoptotic and anti-apoptotic protein expression levels on ethanol induced-ulcer models in rats. For three consecutive days, orogastrically either silk fibroin or saline were given to rats. On the 4th day, animals were deprived of food but allowed free access to water for 24 h before the experiment. While control groups were treated with only physiological saline, the ulcer groups were treated orally either with saline or silk fibroin groups. For ulcer induction, 1 ml of absolute ethanol by gavage were given to both group. Firstly, intracardiac blood was taken at 60 min of EtOH or saline administration and immediately animals were decapitated. In blood samples, the amount of TNF-, IL-1β were analysed whereas in stomach tissues, the levels of MDA, GSH, and MPO activity and the expression levels of bcl-2, Bax, caspase-3 and -9 were determined. In ulcer groups, the amount of TNF- , IL-1β, MDA, MPO, caspase-3 and caspase-9 were found to be significantly higher compared to control groups whereas in GSH, Bcl-2/Bax were found to be lower (p < 0.005). In treatment groups it is observed that silk fibroin recovers the amount of TNF-, IL 1-β, MDA, MPO, GSH, caspase-3, caspase-9, and Bcl2/Bax. In conclusion, for the treatment of the gastric ulcer SF thought to be very efficient therapeutic agent.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacology and Pharmaceutical Sciences (Other)

Journal Section

Research Article

Authors

Aslı Aykaç ^*
0000-0002-4885-5070
Kuzey Kıbrıs Türk Cumhuriyeti

Buse Karanlık This is me
0000-0002-4181-6837
Kuzey Kıbrıs Türk Cumhuriyeti

Ahmet Özer Şehirli
0000-0002-5175-9290
Kuzey Kıbrıs Türk Cumhuriyeti

Publication Date

June 27, 2025

Submission Date

August 2, 2017

Acceptance Date

September 20, 2017

Published in Issue

Year 2018 Volume: 22 Number: 2

IZ

https://izlik.org/JA99NB38ZB

Cite

RIS / Bibtex

APA

Aykaç, A., Karanlık, B., & Şehirli, A. Ö. (2025). Potential protective effects of silk fibroin against ethanol induced gastric ulcer. Journal of Research in Pharmacy, 22(2), 163-172. https://izlik.org/JA99NB38ZB

AMA

1.Aykaç A, Karanlık B, Şehirli AÖ. Potential protective effects of silk fibroin against ethanol induced gastric ulcer. J. Res. Pharm. 2025;22(2):163-172. https://izlik.org/JA99NB38ZB

Chicago

Aykaç, Aslı, Buse Karanlık, and Ahmet Özer Şehirli. 2025. “Potential Protective Effects of Silk Fibroin Against Ethanol Induced Gastric Ulcer”. Journal of Research in Pharmacy 22 (2): 163-72. https://izlik.org/JA99NB38ZB.

EndNote

Aykaç A, Karanlık B, Şehirli AÖ (June 1, 2025) Potential protective effects of silk fibroin against ethanol induced gastric ulcer. Journal of Research in Pharmacy 22 2 163–172.

IEEE

[1]A. Aykaç, B. Karanlık, and A. Ö. Şehirli, “Potential protective effects of silk fibroin against ethanol induced gastric ulcer”, J. Res. Pharm., vol. 22, no. 2, pp. 163–172, June 2025, [Online]. Available: https://izlik.org/JA99NB38ZB

ISNAD

Aykaç, Aslı - Karanlık, Buse - Şehirli, Ahmet Özer. “Potential Protective Effects of Silk Fibroin Against Ethanol Induced Gastric Ulcer”. Journal of Research in Pharmacy 22/2 (June 1, 2025): 163-172. https://izlik.org/JA99NB38ZB.

JAMA

1.Aykaç A, Karanlık B, Şehirli AÖ. Potential protective effects of silk fibroin against ethanol induced gastric ulcer. J. Res. Pharm. 2025;22:163–172.

MLA

Aykaç, Aslı, et al. “Potential Protective Effects of Silk Fibroin Against Ethanol Induced Gastric Ulcer”. Journal of Research in Pharmacy, vol. 22, no. 2, June 2025, pp. 163-72, https://izlik.org/JA99NB38ZB.

Vancouver

1.Aslı Aykaç, Buse Karanlık, Ahmet Özer Şehirli. Potential protective effects of silk fibroin against ethanol induced gastric ulcer. J. Res. Pharm. [Internet]. 2025 Jun. 1;22(2):163-72. Available from: https://izlik.org/JA99NB38ZB