Electroanalytical determination of salbutamol in pharmaceutical formulations using cathodically pretreated boron-doped diamond electrode

Year 2018, Volume: 22 Issue: 3, 460 - 468, 27.06.2025

Pınar Talay Pınar , Hoshyar Saadi Ali Abdullah Abdulwahed Abdullah Yavuz Yardım , Zühre Şentürk

https://doi.org/10.12991/jrp.2018.88

Cited By: 5

https://izlik.org/JA36LM32UM

Abstract

This paper examined for the first time the possibilities of the usage of the cathodically pretreated borondoped diamond (CPT-BDD) electrode for the redox behavior of salbutamol (SAL) using cyclic and adsorptive stripping voltammetry. The cyclic voltammograms showed an irreversible and adsorption-controlled oxidation peak at about +1.0 V in the Britton-Robinson (BR) buffer (pH 9.0) solution. Under the optimized experimental condition, using squarewave adsorptive stripping mode, the compound yielded a well-defined voltammetric response in BR buffer, pH 9.0 at +0.95 V (vs. Ag/AgCl) (after 30 s accumulation at an open circuit condition). A linear calibration graph was obtained in the concentration range of 4.15 to 83 μg mL-1 (1.73x10-5 -3.47x10-4 M). A detection limit of 1.21 μg mL-1 (5.06x10-6 M) was observed. The suggested method was also applied to the determination of SAL in the drug formulations.

Keywords

Salbutamol , boron-doped diamond electrode , square-wave adsorptive stripping voltammetry , pharmaceutical formulations

References

• [1] Kraft A. Doped diamond: A compact review on a new, versatile electrode material. Int J Electrochem Sci. 2007;2:355-358.
• [2] Luong JHT, Male KB, Glennon JD. Boron-doped diamond electrode: synthesis, characterization, functionalization and analytical applications. Analyst. 2009;134(10):1965-1979.
• [3] Yiğit A, Yardım Y, Selçuk Zorer Ö, Şentürk Z. Electrochemical determination of pterostilbene at a cathodically pretreated boron-doped diamond electrode using square-wave adsorptive anodic stripping voltammetry in cationic surfactant media. Sens Actuator B-Chem. 2016;23:688-695.
• [4] Yiğit A, Yardım Y, Şentürk Z. Voltammetric sensor based on boron-doped diamond electrode for simultaneous determination of paracetamol, caffeine, and aspirin in pharmaceutical formulations. IEEE Sens J. 2016;16(6):1674-1680.
• [5] Saadi Ali H, Abdullah AA, Pınar PT, Yardım Y, Şentürk Z. Simultaneous voltammetric determination of vanillin and caffeine in food products using an anodically pretreated boron-doped diamond electrode: Its comparison with HPLC-DAD. Talanta. 2017;170:384-391.
• [6] Samiec P, Švorc Ľ, Stanković DM, Vojs M, Marton M, Navrátilová Z. Mercury-free and modification-free electroanalytical approach towards bromazepam and alprazolam sensing: A facile and efficient assay for their quantification in pharmaceuticals using boron-doped diamond electrodes. Sens Actuator B-Chem. 2017;245:963-971.
• [7] Stanković DM, Švorc Ľ, Mariano JFML, Ortner A, Kalcher K. Electrochemical determination of natural drug colchicine in pharmaceuticals and human serum sample and its interaction with DNA. Electroanalysis. 2017;29(10):2276-2281.
• [8] Talay Pınar P, Şentürk Z. Voltammetric investigation of antiviral drug valacyclovir at a boron-doped diamond electrode in different electrolyte media: Its determination enhanced by anionic surfactant in pharmaceuticals and biological fluids. Curr Pharm Anal. 2017;13(2):175-187.
• [9] Caiyun L, Long W. Research on determination of clenbuterol and salbutamol in pork by SPE-HPLC. IEEE Sens J. 2011;1024-1026.
• [10] Bernal JL, del Nozal MJ, Velasco H, Toribio L. HPLC versus SFC for the determination of salbutamol sulphate and its impurities in pharmaceuticals. J Liq Chromatogr Relat Technol. 1996;19(10):1579-1589.
• [11] Geeta N, Baggi TR. An improved spectrophotometric method for the determination of salbutamol sulfate with 3-methylbenzthiazolinone-2-hydrazone. Microchem J. 1989;39(2):137-144.
• [12] Rotta ET, Amantéa SL, Froehlich PE, Becker A. Determination of plasma salbutamol concentrations after nebulization in a pediatric emergency department. J Pediatr. 2007;83(5):481-484.
• [13] Vela J, Yanes EG, Stalcup AM. Quantitative determination of clenbuterol, salbutamol and tulobuterol enantiomers by capillary electrophoresis. Fresenius J Anal Chem. 2001;369(3-4):212-219.
• [14] Rele RV. UV-spectrophotometric third order derivative method for simultaneous estimation of ambroxal hydrochloride and salbutamol sulphate in combined pharmaceutical dosage form. Der Pharmacia Lettre. 2016;8(3):261-266.
• [15] Rele RV. Simultaneous UV-spectrophotometric estimation of bromhexine hydrochloride and salbutamol sulphate by second order derivative method in combined dosage form. Res J Pharm Tech. 2015;8(6):702-706.
• [16] Rele RV. Simultaneous spectrophotometric estimation of ambroxal hydrochloride and salbutamol sulphate by second order derivative method in combined dosage form. Res J Pharm Tech. 2015;8(4):432-436.
• [17] Qin Y, Zou Y, Liang M, Yu Q, Huang Y, Li T, Xu X. Determination of salbutamol in human plasma by column-switching HPLC with UV detection. Sichuan Da Xue Xue Bao Yi Xue Ban. 2003;34(3):576-579.
• [18] Zhang XZ, Gan YR, Zhao FN. Determination of salbutamol in human plasma and urine by high-performance liquid chromatography with a coulometric electrode array system. J Chromatogr Sci. 2004;42(5):263-267.
• [19] Erram SV, Fanska CB, Asif M. Determination of albuterol sulfate and its related substances in albuterol sulfate inhalation solution, 0.5% by RP-HPLC. J Pharm Biomed Anal. 2006;40(4):864-874.
• [20] Zhenjiang L, Bo Z, Jianfan S, Yinhui Y, Ming L, Daolin D, Fang Z, Jiawen L. Highly efficient detection of salbutamol in environmental water samples by an enzyme immunoassay. Sci Total Environ. 2018;613-614:861-865.
• [21] Rosales-Conrado N, Dell'Aica M, León-González MED, Pérez-Arribas LV, Polo-Díez LM. Determination of salbutamol by direct chiral reversed-phase HPLC using teicoplanin as stationary phase and its application to natural water analysis. Biomed Chromatogr. 2013;27(11):1413-1422.
• [22] Montes Nino AM, Granja RHMM, Reche KVG, Wanschel ACBA, Salerno AG. Laboratory validation of an LC-MS/MS method for the detection of ractopamine, clenbuterol and salbutamol in bovine and swine muscle at sub-μg kg–1 regulatory limits. Food Addit Contam Part A Chem. 2017;34(5):785-792.
• [23] Chan SH, Lee W, Asmawi MZ, Tan SC. Chiral liquid chromatography-mass spectrometry (LC-MS/MS) method development for the detection of salbutamol in urine samples. J Chromatogr B Analyt Technol Biomed Life Sci. 2016;1025:83-91.
• [24] Wang Y, Caldwell R, Cowan DA, Legido-Quigley C. LC-MS-based metabolomics discovers purine endogenous associations with low-dose salbutamol in urine collected for antidoping tests. Anal Chem. 2016;88(4):2243-2249.
• [25] Zhou T, Zeng J, Liu S, Xu L, Tan W. Study on the determination and chiral inversion of R-salbutamol in human plasma and urine by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2015;1002:218-227.
• [26] Pérez-Silva I, Ramírez-Silva MT, Galán-Vidal CA, Rodríguez JA, Páez-Hernández ME. Evaluation of the use of solvent impregnated resins in the analysis of salbutamol in human urine followed by capillary electrophoresis. React Funct Polym. 2016;105:89-94.
• [27] Fan LY, Chen Q, Zhang W, Cao CX. Sensitive determination of illegal drugs of clenbuterol and salbutamol in swine urine by capillary electrophoresis with on-line stacking based on the moving reaction boundary. Anal Methods. 2013;5(11):2848-2853.
• [28] Samir A, Lotfy HM, Salem H, Abdelkawy M. Development and validation of simultaneous spectrophotometric and TLC-spectrodensitometric methods for determination of beclomethasone dipropionate and salbutamol in combined dosage form. Spectrochim Acta A Mol Biomol Spectrosc. 2014;128:127-136.
• [29] Dave Hiral N, Mashru Rajeshree C, Patel Alpesh K. Thin layer chromatographic method for the determination of ternary mixture containing salbutamol sulphate, ambroxol hydrochloride and theophylline. Int J Pharm Sci. 2010;2:390-394.
• [30] Liu Z, Zhang B, Sun J, Zhu F, Luan J. Highly efficient detection of salbutamol in environmental water samples by an enzyme immunoassay. Sci Total Environ. 2018;613:861-865.
• [31] Dong T, Tang Q, Zhao K, Deng A, Li J. Ultrasensitive electrochemiluminescent salbutamol immunoassay with dual-signal amplification using CdSe@SiO2 as label and gold nanoparticles as substrate. Microchim Acta. 2017;184(3):961-968.
• [32] Du P. Preparation of molecular imprinting electro-biosensor for the rapid detection of salbutamol and its application in food. Mod Food Sci Technol. 2017;33(2):250-255.
• [33] Guo XC, Wang HH, Chen XJ, Kang WY, Zhou WH. One step electrodeposition of graphene-Au nanocomposites for highly sensitive electrochemical detection of salbutamol. Int J Electrochem Sci. 2017;12:861-875.
• [34] Rajkumar M, Li YS, Chen SM. Electrochemical detection of toxic ractopamine and salbutamol in pig meat and human urine samples by using poly taurine/zirconia nanoparticles modified electrodes. Colloids Surf B Biointerfaces. 2013;110:242-247.
• [35] Lin KC, Hong CP, Chen SM. Simultaneous determination for toxic ractopamine and salbutamol in pork sample using hybrid carbon nanotubes. Sens Actuators B Chem. 2013;177:428-436.
• [36] Attaran AM, Javanbakht M, Fathollahi F, Enhessari M. Determination of salbutamol in pharmaceutical and serum samples by adsorptive stripping voltammetry on a carbon paste electrode modified by iron titanate nanopowders. Electroanalysis. 2012;24(10):2013-2020.
• [37] Mi Q, Wang ZW, Chai CY, Zhao B, Chen CY. Multilayer structured immunosensor based on a glassy carbon electrode modified with multi-wall carbon nanotubes, polythionine, and gold nanoparticles. Microchim Acta. 2011;173(3):459-467.
• [38] Shen L, Li Z, He P. Electrochemical behavior of β2-agonists at graphite nanosheet modified electrodes. Electrochem Commun. 2010;12(7):876-881.
• [39] Yılmaz N, Özkan SA, Uslu B, Şentürk Z, Biryol İ. Voltammetric determination of salbutamol based on electrochemical oxidation at platinum and glassy carbon electrodes. Tr J Chem. 1998;22(2):175-182.
• [40] Wei Y, Zhang Q, Shao C, Zhang L, Li X. Voltammetric determination of salbutamol on a glassy carbon electrode coated with a nanomaterial thin film. J Anal Chem. 2010;65(4):398-403.
• [41] Bard AJ, Faulkner LR. Electrochemical Methods: Fundamentals and Applications, 2nd ed., John Wiley & Sons, Inc, New York, 2000.