The role of neurotensin receptor 1 on fear memory in mice

Sedef Akbaş; Ruhan Deniz Topuz

The role of neurotensin receptor 1 on fear memory in mice

Abstract

Neurotensin (NT) is commonly found in the central nervous system and the gastrointestinal tract and known to play role as a neurotransmitter/neuromodulator/neurohormone. We aimed to investigate the effect of the neurotensin receptor agonist PD149163 and the neurotensin receptor antagonist SR142948 on contextual and cued fear conditioning. In total 174 male Balb/c mice were divided into 29 groups. In the behavioral experiments, the NT receptor agonist PD149163 (0.25, 1, 4 mg/kg) or NT receptor antagonist SR142948 (0.1, 1, 3 mg/kg) were administered to subjects before conditioning on the first day (acquisition phase) or before the test performed 24 h after conditioning (retrieval). Rota-rod test, contextual and cued fear conditioning test were performed in all groups. It was observed that the neurotensin receptor agonist PD149163 had no effect on learning in the cued fear conditioning test, but enhanced retrieval dose-dependently. The neurotensin receptor antagonist SR142948 did not affect the learning and retrieval processes in cued fear conditioning. In the contextual fear conditioning test, neither the neurotensin receptor agonist PD149163 nor the neurotensin receptor antagonist SR142948 had any effect on the learning or retrieval of fear conditioning. Our results show that neurotensin receptor agonist PD149163 increases amygdala dependent cued fear conditioning responses dose-dependently.

Keywords

References

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Details

Primary Language

English

Subjects

Medical Pharmacology

Journal Section

Research Article

Authors

Sedef Akbaş ^* This is me
Türkiye

Ruhan Deniz Topuz
Türkiye

Publication Date

June 28, 2025

Submission Date

December 31, 2020

Acceptance Date

June 28, 2021

Published in Issue

Year 2021 Volume: 25 Number: 5

IZ

https://izlik.org/JA32TJ96ZU

Cite

RIS / Bibtex

APA

Akbaş, S., & Topuz, R. D. (2025). The role of neurotensin receptor 1 on fear memory in mice. Journal of Research in Pharmacy, 25(5), 609-615. https://izlik.org/JA32TJ96ZU

AMA

1.Akbaş S, Topuz RD. The role of neurotensin receptor 1 on fear memory in mice. J. Res. Pharm. 2025;25(5):609-615. https://izlik.org/JA32TJ96ZU

Chicago

Akbaş, Sedef, and Ruhan Deniz Topuz. 2025. “The Role of Neurotensin Receptor 1 on Fear Memory in Mice”. Journal of Research in Pharmacy 25 (5): 609-15. https://izlik.org/JA32TJ96ZU.

EndNote

Akbaş S, Topuz RD (July 1, 2025) The role of neurotensin receptor 1 on fear memory in mice. Journal of Research in Pharmacy 25 5 609–615.

IEEE

[1]S. Akbaş and R. D. Topuz, “The role of neurotensin receptor 1 on fear memory in mice”, J. Res. Pharm., vol. 25, no. 5, pp. 609–615, July 2025, [Online]. Available: https://izlik.org/JA32TJ96ZU

ISNAD

Akbaş, Sedef - Topuz, Ruhan Deniz. “The Role of Neurotensin Receptor 1 on Fear Memory in Mice”. Journal of Research in Pharmacy 25/5 (July 1, 2025): 609-615. https://izlik.org/JA32TJ96ZU.

JAMA

1.Akbaş S, Topuz RD. The role of neurotensin receptor 1 on fear memory in mice. J. Res. Pharm. 2025;25:609–615.

MLA

Akbaş, Sedef, and Ruhan Deniz Topuz. “The Role of Neurotensin Receptor 1 on Fear Memory in Mice”. Journal of Research in Pharmacy, vol. 25, no. 5, July 2025, pp. 609-15, https://izlik.org/JA32TJ96ZU.

Vancouver

1.Sedef Akbaş, Ruhan Deniz Topuz. The role of neurotensin receptor 1 on fear memory in mice. J. Res. Pharm. [Internet]. 2025 Jul. 1;25(5):609-15. Available from: https://izlik.org/JA32TJ96ZU