Effect of aerial part and root extracts from Ferulago mughlae Peșmen and Ferulago sandrasica Peșmen & Quézel growing in Turkey on erectile dysfunction in streptozotocin-induced diabetic rats

Songül Karakaya; Fatma Gül Delimustafaoğlu; Didem Yilmaz Oral; Serap Gur

Effect of aerial part and root extracts from Ferulago mughlae Peșmen and Ferulago sandrasica Peșmen & Quézel growing in Turkey on erectile dysfunction in streptozotocin-induced diabetic rats

Abstract

Ferulago species have been utilised since ancient times as antihelmentic, peptic, sedative and aphrodisiac, and as the seasoning in view of their special odors. In Turkish traditional medicine, the roots from some members of this genus are utilized as aphrodisiac, so we determined to show in vitro relaxant effect of F. mughlae Peșmen and F. sandrasica Peșmen & Quézel species extracts on corpus cavernosum (CC). A totality of 20 adult male Sprague-Dawley rats (diabetic and control groups) were induced by single intraperitoneal injection of 40 mg/kg of Streptozotocin. In vitro organ bath tests were carried out on rats to evaluate isometric pressure. Tissues were stretched with phenylephrine (Phe), and relaxation responses relevant to acetylcholine (ACh, 1 mM ), sodium nitroprusside (SNP 0.1 µM ) and electrical field stimulation (EFS, frequency 20 Hz) were gained. Whole these concentration-response curves were replicated with aqueous extracts obtained from the aerial parts and roots. The extracts were active in both groups. It was found that root extracts of F. mughlae and F. sandrasica yielded 97.80% and 97.55% relaxation. Among the extracts of roots (especially roots of F. mughlae) showed the best activity. On the other hand, lyophilized aqueous extracts of aerial part (especially F. sandrasica) showed the worst activity. Based on this findings, the roots of this species deserve further in vivo assessments for their aphrodisiac potential.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacognosy

Journal Section

Research Article

Authors

Songül Karakaya ^*
Türkiye

Fatma Gül Delimustafaoğlu
Türkiye

Didem Yilmaz Oral This is me
Türkiye

Serap Gur
Türkiye

Publication Date

June 27, 2025

Submission Date

March 27, 2018

Acceptance Date

August 14, 2018

Published in Issue

Year 2019 Volume: 23 Number: 2

IZ

https://izlik.org/JA58HE86DZ

Cite

RIS / Bibtex

APA

Karakaya, S., Delimustafaoğlu, F. G., Yilmaz Oral, D., & Gur, S. (2025). Effect of aerial part and root extracts from Ferulago mughlae Peșmen and Ferulago sandrasica Peșmen & Quézel growing in Turkey on erectile dysfunction in streptozotocin-induced diabetic rats. Journal of Research in Pharmacy, 23(2), 235-241. https://izlik.org/JA58HE86DZ

AMA

1.Karakaya S, Delimustafaoğlu FG, Yilmaz Oral D, Gur S. Effect of aerial part and root extracts from Ferulago mughlae Peșmen and Ferulago sandrasica Peșmen & Quézel growing in Turkey on erectile dysfunction in streptozotocin-induced diabetic rats. J. Res. Pharm. 2025;23(2):235-241. https://izlik.org/JA58HE86DZ

Chicago

Karakaya, Songül, Fatma Gül Delimustafaoğlu, Didem Yilmaz Oral, and Serap Gur. 2025. “Effect of Aerial Part and Root Extracts from Ferulago Mughlae Peșmen and Ferulago Sandrasica Peșmen & Quézel Growing in Turkey on Erectile Dysfunction in Streptozotocin-Induced Diabetic Rats”. Journal of Research in Pharmacy 23 (2): 235-41. https://izlik.org/JA58HE86DZ.

EndNote

Karakaya S, Delimustafaoğlu FG, Yilmaz Oral D, Gur S (June 1, 2025) Effect of aerial part and root extracts from Ferulago mughlae Peșmen and Ferulago sandrasica Peșmen & Quézel growing in Turkey on erectile dysfunction in streptozotocin-induced diabetic rats. Journal of Research in Pharmacy 23 2 235–241.

IEEE

[1]S. Karakaya, F. G. Delimustafaoğlu, D. Yilmaz Oral, and S. Gur, “Effect of aerial part and root extracts from Ferulago mughlae Peșmen and Ferulago sandrasica Peșmen & Quézel growing in Turkey on erectile dysfunction in streptozotocin-induced diabetic rats”, J. Res. Pharm., vol. 23, no. 2, pp. 235–241, June 2025, [Online]. Available: https://izlik.org/JA58HE86DZ

ISNAD

Karakaya, Songül - Delimustafaoğlu, Fatma Gül - Yilmaz Oral, Didem - Gur, Serap. “Effect of Aerial Part and Root Extracts from Ferulago Mughlae Peșmen and Ferulago Sandrasica Peșmen & Quézel Growing in Turkey on Erectile Dysfunction in Streptozotocin-Induced Diabetic Rats”. Journal of Research in Pharmacy 23/2 (June 1, 2025): 235-241. https://izlik.org/JA58HE86DZ.

JAMA

1.Karakaya S, Delimustafaoğlu FG, Yilmaz Oral D, Gur S. Effect of aerial part and root extracts from Ferulago mughlae Peșmen and Ferulago sandrasica Peșmen & Quézel growing in Turkey on erectile dysfunction in streptozotocin-induced diabetic rats. J. Res. Pharm. 2025;23:235–241.

MLA

Karakaya, Songül, et al. “Effect of Aerial Part and Root Extracts from Ferulago Mughlae Peșmen and Ferulago Sandrasica Peșmen & Quézel Growing in Turkey on Erectile Dysfunction in Streptozotocin-Induced Diabetic Rats”. Journal of Research in Pharmacy, vol. 23, no. 2, June 2025, pp. 235-41, https://izlik.org/JA58HE86DZ.

Vancouver

1.Songül Karakaya, Fatma Gül Delimustafaoğlu, Didem Yilmaz Oral, Serap Gur. Effect of aerial part and root extracts from Ferulago mughlae Peșmen and Ferulago sandrasica Peșmen & Quézel growing in Turkey on erectile dysfunction in streptozotocin-induced diabetic rats. J. Res. Pharm. [Internet]. 2025 Jun. 1;23(2):235-41. Available from: https://izlik.org/JA58HE86DZ