Chemical analysis and enzyme inhibitory activities of essential oil obtained from Allium proponticum subsp. proponticum, an endemic species

Ceren Emir; Ahmet Emir

Chemical analysis and enzyme inhibitory activities of essential oil obtained from Allium proponticum subsp. proponticum, an endemic species

Abstract

Allium species belong to the Amaryllidaceae family and are represented with approximately 900 species, with 220 taxa found in Turkey. The aim of the present study is to analyze the chemical structure and to investigate the enzyme inhibitory activities linked to Alzheimer's Disease, skin disorders, and type 2 Diabetes Mellitus of essential oil obtained from Allium proponticum subsp. proponticum, which is an endemic species. The essential oil was obtained with hydrodistillation using a Clevenger-type apparatus from flower parts of the plant and the analysis was carried out by Gas Chromatography Mass Spectrometry. Inhibitory activities of samples against acetylcholinesterase, butyrylcholinesterase, tyrosinase, α-amylase, and α-glucosidase were realized in a 96-well microplate using an ELISA microplate reader. The yield of essential oils was 0.0095 %. A total of 17 components, 11 of sulfur-containing compounds (73.83 %), were identified, constituting 86.72 % of the total essential oil. IC50 values of enzymes inhibitory activities were 258.47 ± 3.28 for acetylcholinesterase, 522.81 ± 1.29 for butyrylcholinesterase, 38.22 ± 1.87 for tyrosinase, 28.50 ± 1.12 for α-glucosidase and 14.68 ± 0.78 for α-amylase. To conclude, the essential oil of Allium proponticum subsp. proponticum with its sulfur-containing compounds

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacognosy

Journal Section

Research Article

Authors

Ceren Emir
0000-0001-8516-9830
Türkiye

Ahmet Emir ^*
0000-0002-0971-7716
Türkiye

Publication Date

June 28, 2025

Submission Date

November 1, 2021

Acceptance Date

February 13, 2022

Published in Issue

Year 2022 Volume: 26 Number: 3

IZ

https://izlik.org/JA55ES78WT

Cite

RIS / Bibtex

APA

Emir, C., & Emir, A. (2025). Chemical analysis and enzyme inhibitory activities of essential oil obtained from Allium proponticum subsp. proponticum, an endemic species. Journal of Research in Pharmacy, 26(3), 574-580. https://izlik.org/JA55ES78WT

AMA

1.Emir C, Emir A. Chemical analysis and enzyme inhibitory activities of essential oil obtained from Allium proponticum subsp. proponticum, an endemic species. J. Res. Pharm. 2025;26(3):574-580. https://izlik.org/JA55ES78WT

Chicago

Emir, Ceren, and Ahmet Emir. 2025. “Chemical Analysis and Enzyme Inhibitory Activities of Essential Oil Obtained from Allium Proponticum Subsp. Proponticum, an Endemic Species”. Journal of Research in Pharmacy 26 (3): 574-80. https://izlik.org/JA55ES78WT.

EndNote

Emir C, Emir A (June 1, 2025) Chemical analysis and enzyme inhibitory activities of essential oil obtained from Allium proponticum subsp. proponticum, an endemic species. Journal of Research in Pharmacy 26 3 574–580.

IEEE

[1]C. Emir and A. Emir, “Chemical analysis and enzyme inhibitory activities of essential oil obtained from Allium proponticum subsp. proponticum, an endemic species”, J. Res. Pharm., vol. 26, no. 3, pp. 574–580, June 2025, [Online]. Available: https://izlik.org/JA55ES78WT

ISNAD

Emir, Ceren - Emir, Ahmet. “Chemical Analysis and Enzyme Inhibitory Activities of Essential Oil Obtained from Allium Proponticum Subsp. Proponticum, an Endemic Species”. Journal of Research in Pharmacy 26/3 (June 1, 2025): 574-580. https://izlik.org/JA55ES78WT.

JAMA

1.Emir C, Emir A. Chemical analysis and enzyme inhibitory activities of essential oil obtained from Allium proponticum subsp. proponticum, an endemic species. J. Res. Pharm. 2025;26:574–580.

MLA

Emir, Ceren, and Ahmet Emir. “Chemical Analysis and Enzyme Inhibitory Activities of Essential Oil Obtained from Allium Proponticum Subsp. Proponticum, an Endemic Species”. Journal of Research in Pharmacy, vol. 26, no. 3, June 2025, pp. 574-80, https://izlik.org/JA55ES78WT.

Vancouver

1.Ceren Emir, Ahmet Emir. Chemical analysis and enzyme inhibitory activities of essential oil obtained from Allium proponticum subsp. proponticum, an endemic species. J. Res. Pharm. [Internet]. 2025 Jun. 1;26(3):574-80. Available from: https://izlik.org/JA55ES78WT