Forty Micromole Hydroxychloroquine Enhanced Cytotoxic Effect of Doxorubicin Against Laryngeal Cancer Cell Line HEp-2

Year 2022, Volume: 26 Issue: 4 , 714 - 721 , 28.06.2025

Hasanain Kamil Owadh Rana A. Ghaleb Fatima Adnan Alzubaidi

https://izlik.org/JA35GH98LS

Abstract

Autophagy processes are essential biological mechanisms control human cell survival and induction of
cell death. Many researches indicate that cancer cells growth is affected by inhibition or induction of autophagy
processes and laryngeal cancer "the most common type of head and neck cancer" is one of various types of tumors
which effected by autophagy process. Numerous articles studied impact of adding autophagy inhibiter to cancer
treatment protocol, and the current work study the in-vitro anticancer effect of doxorubicin alone and in combination
with an autophagy inhibitor agent hydroxychloroquine against HEp-2 (laryngeal cancer) cell line. The present study
suggested valuable effect of doxorubicin anticancer activity against HEp-2 cell line when used after hydroxychloroquine
pretreatment, which may play promising role in treatment of laryngeal cancer.

Keywords

Autophagy , autophagy inhibitor , doxorubicin , head and neck cancer , HEp-2 , hydroxychloroquine

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