Novel pyrazole substituted oxazole derivatives: Design, insilico studies, synthesis & biological activities

Singagari Srilakshmi; Raja Sundararajan

Novel pyrazole substituted oxazole derivatives: Design, insilico studies, synthesis & biological activities

Abstract

A potent antibacterial drug was developed by synthesizing a set of new pyrazoles substituted oxazole derivatives using multi-step synthesis. FT-IR, 1H-NMR, Mass spectroscopy, and bases of microanalyses are employed to confirm the structure of compounds. Molinspiration online tool was used to predict the molecular properties and molecular docking was used to predict the antitubercular potency of the target compounds. 10-Fold serial dilution method, agar streak dilution test, and DPPH radical scavenging methods are utilized to evaluate antitubercular, antibacterial, and radical scavenging properties of test compounds and reference drugs, respectively. Varying degree of antitubercular, antibacterial, and radical scavenging activities (mild to good) was displayed by synthesized oxazole compounds. In general, unsubstituted oxazole derivatives exhibited superior antibacterial potency than substituted analogs. In addition, meta-substituted analogs displayed higher activity than the corresponding para-substituted analogs. Among fifteen tested target compounds, the potent compound of this series was found to be 4-(4-(5-phenyl- 4,5-dihydro-1H-pyrazol-3-yl)benzylidene)-2-methyloxazol-5(4H)-one (PBO8). Hence, this analog may be used as a lead molecule to find potent & safer antibacterial agents.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Chemistry

Journal Section

Research Article

Authors

Singagari Srilakshmi
0000-0002-3912-4460
India

Raja Sundararajan ^*
0000-0003-2229-6423
India

Publication Date

June 28, 2025

Submission Date

October 7, 2021

Acceptance Date

January 11, 2022

Published in Issue

Year 2022 Volume: 26 Number: 3

IZ

https://izlik.org/JA39UL46MW

Cite

RIS / Bibtex

APA

Srilakshmi, S., & Sundararajan, R. (2025). Novel pyrazole substituted oxazole derivatives: Design, insilico studies, synthesis & biological activities. Journal of Research in Pharmacy, 26(3), 625-640. https://izlik.org/JA39UL46MW

AMA

1.Srilakshmi S, Sundararajan R. Novel pyrazole substituted oxazole derivatives: Design, insilico studies, synthesis & biological activities. J. Res. Pharm. 2025;26(3):625-640. https://izlik.org/JA39UL46MW

Chicago

Srilakshmi, Singagari, and Raja Sundararajan. 2025. “Novel Pyrazole Substituted Oxazole Derivatives: Design, Insilico Studies, Synthesis & Biological Activities”. Journal of Research in Pharmacy 26 (3): 625-40. https://izlik.org/JA39UL46MW.

EndNote

Srilakshmi S, Sundararajan R (June 1, 2025) Novel pyrazole substituted oxazole derivatives: Design, insilico studies, synthesis & biological activities. Journal of Research in Pharmacy 26 3 625–640.

IEEE

[1]S. Srilakshmi and R. Sundararajan, “Novel pyrazole substituted oxazole derivatives: Design, insilico studies, synthesis & biological activities”, J. Res. Pharm., vol. 26, no. 3, pp. 625–640, June 2025, [Online]. Available: https://izlik.org/JA39UL46MW

ISNAD

Srilakshmi, Singagari - Sundararajan, Raja. “Novel Pyrazole Substituted Oxazole Derivatives: Design, Insilico Studies, Synthesis & Biological Activities”. Journal of Research in Pharmacy 26/3 (June 1, 2025): 625-640. https://izlik.org/JA39UL46MW.

JAMA

1.Srilakshmi S, Sundararajan R. Novel pyrazole substituted oxazole derivatives: Design, insilico studies, synthesis & biological activities. J. Res. Pharm. 2025;26:625–640.

MLA

Srilakshmi, Singagari, and Raja Sundararajan. “Novel Pyrazole Substituted Oxazole Derivatives: Design, Insilico Studies, Synthesis & Biological Activities”. Journal of Research in Pharmacy, vol. 26, no. 3, June 2025, pp. 625-40, https://izlik.org/JA39UL46MW.

Vancouver

1.Singagari Srilakshmi, Raja Sundararajan. Novel pyrazole substituted oxazole derivatives: Design, insilico studies, synthesis & biological activities. J. Res. Pharm. [Internet]. 2025 Jun. 1;26(3):625-40. Available from: https://izlik.org/JA39UL46MW