Formulation and evaluation of Lornoxicam mucoadhesive buccal films

Magdy Ibrahim Mohamed; Khaled Fathey El-shaboury; Mohamed Aly Abdallah

Formulation and evaluation of Lornoxicam mucoadhesive buccal films

Abstract

Lornoxicam (LN) is a non-steroidal anti-inflammatory and analgesic drug of the oxicam class. As with other non-steroidal anti-inflammatory drugs, it has the same side effects of this group of drugs if they are taken orally such as gastrointestinal, renal and hepatic disorders. Besides, it binds extensively to plasma albumin (99%), has a relatively short plasma half-life (3 to 5 hrs) and undergoes first pass hepatic metabolism and gastrointestinal degradation upon oral administration. These drawbacks render LN a good candidate for local delivery via sustained release dosage forms. Therefore, LN mucoadhesive buccal films were prepared by the solvent casting method using different polymers, that is sodium carboxymethyl cellulose (Na CMC), hydroxypropylmethyl cellulose (HPMC), hydroxypropyl cellulose (HPC), gelatin, polyethylene glycol (PEG) and polyvinyl pyrrolidone (PVP) K-30. Differential scanning calorimetry (DSC) and infrared spectroscopy (IR) studies indicated the absence of any physical or chemical interaction of the drug with any of the used polymers. The prepared films were evaluated for their weight uniformity, thickness uniformity, swelling index, surface pH, folding endurance, in vitro drug release as well as mucoadhesion force. On the basis of the results obtained, it was deduced that the best formula of LN mucoadhesive buccal films was that containing a mixture of Na CMC, HPC and PVP; since it exhibited a high bioadhesive strength, a high percentage of drug release, a good folding endurance and a high swelling index. It can be finally concluded that mucoadhesive buccal films can be one of the alternatives available for administration of LN in order to minimize its side effects and avoid the disadvantages of parenteral and oral routes of administration.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Delivery Technologies

Journal Section

Research Article

Authors

Magdy Ibrahim Mohamed ^* This is me
0000-0002-0480-7720
Egypt

Khaled Fathey El-shaboury This is me
0009-0008-2278-7381
Egypt

Mohamed Aly Abdallah This is me
Egypt

Publication Date

June 28, 2025

Submission Date

April 4, 2024

Acceptance Date

May 17, 2024

Published in Issue

Year 2024 Volume: 28 Number: 4

IZ

https://izlik.org/JA28WN68FL

Cite

RIS / Bibtex

APA

Mohamed, M. I., El-shaboury, K. F., & Abdallah, M. A. (2025). Formulation and evaluation of Lornoxicam mucoadhesive buccal films. Journal of Research in Pharmacy, 28(4), 1152-1165. https://izlik.org/JA28WN68FL

AMA

1.Mohamed MI, El-shaboury KF, Abdallah MA. Formulation and evaluation of Lornoxicam mucoadhesive buccal films. J. Res. Pharm. 2025;28(4):1152-1165. https://izlik.org/JA28WN68FL

Chicago

Mohamed, Magdy Ibrahim, Khaled Fathey El-shaboury, and Mohamed Aly Abdallah. 2025. “Formulation and Evaluation of Lornoxicam Mucoadhesive Buccal Films”. Journal of Research in Pharmacy 28 (4): 1152-65. https://izlik.org/JA28WN68FL.

EndNote

Mohamed MI, El-shaboury KF, Abdallah MA (July 1, 2025) Formulation and evaluation of Lornoxicam mucoadhesive buccal films. Journal of Research in Pharmacy 28 4 1152–1165.

IEEE

[1]M. I. Mohamed, K. F. El-shaboury, and M. A. Abdallah, “Formulation and evaluation of Lornoxicam mucoadhesive buccal films”, J. Res. Pharm., vol. 28, no. 4, pp. 1152–1165, July 2025, [Online]. Available: https://izlik.org/JA28WN68FL

ISNAD

Mohamed, Magdy Ibrahim - El-shaboury, Khaled Fathey - Abdallah, Mohamed Aly. “Formulation and Evaluation of Lornoxicam Mucoadhesive Buccal Films”. Journal of Research in Pharmacy 28/4 (July 1, 2025): 1152-1165. https://izlik.org/JA28WN68FL.

JAMA

1.Mohamed MI, El-shaboury KF, Abdallah MA. Formulation and evaluation of Lornoxicam mucoadhesive buccal films. J. Res. Pharm. 2025;28:1152–1165.

MLA

Mohamed, Magdy Ibrahim, et al. “Formulation and Evaluation of Lornoxicam Mucoadhesive Buccal Films”. Journal of Research in Pharmacy, vol. 28, no. 4, July 2025, pp. 1152-65, https://izlik.org/JA28WN68FL.

Vancouver

1.Magdy Ibrahim Mohamed, Khaled Fathey El-shaboury, Mohamed Aly Abdallah. Formulation and evaluation of Lornoxicam mucoadhesive buccal films. J. Res. Pharm. [Internet]. 2025 Jul. 1;28(4):1152-65. Available from: https://izlik.org/JA28WN68FL