Boron nitride nanoparticles: Preparation, characterization, stability and evaluation of antibacterial activities

Emrah Özakar; Rukiye Sevinç Özakar; Mehmet Cemal Adigüzel

Boron nitride nanoparticles: Preparation, characterization, stability and evaluation of antibacterial activities

Abstract

In recent years, antibiotics have been the ideal drugs for treating infections caused by microorganisms due to their broad-spectrum effects. However, as a result of the unconscious and widespread use of antibiotics, an important disadvantage of current treatments is the emergence of resistant bacteria. With the development of nanotechnology, nano-sized materials, which have entered our lives, have started to be used frequently in health. Nano-sized materials may form lower resistance compared to conventional antibiotics. Boron nitride has outstanding optical and mechanical properties; It is one of the boron derivatives widely used in biomedical applications today. In this study, boron nitride nanoparticles were obtained by emulsification-solvent evaporation method, characterization (size, zeta potential, PDI, SEM, FTIR and XRD) studies were performed, stability was investigated, and potential antibacterial effect on nine different microorganisms was evaluated by minimum inhibitory concentration (MIC) and agar-well disc diffusion method. In our study, boron nitride nanoparticles were successfully prepared by an emulsification-solvent evaporation method, which is a top-down technique, easily, rapidly and in high yield. Surprisingly, our 466 nm boron nitride nanoparticles with high negative zeta potential (-38.4±0.90 mV) and highly homogeneous particle size distribution (0.144±0.01 PDI) influenced all nine different bacteria. Our negatively charged boron nitride nanoparticles showed a very high inhibitory effect, especially on Bacillus cereus, Escherichia coli and Staphylococcus aureus, even at very low doses (0.02±0.01, 0.80±0.23 and 0.05±0.03 µg/mL, respectively). This study was conducted to prepare nanoparticle formulations of water-insoluble Boron nitride, characterize them, stability and determine their therapeutic effectiveness on nine different bacteria. These findings may make boron nitride nanoparticles not only a reliable and effective antimicrobial agent in health and cosmetics but also an optimal alternative for food preservation.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Delivery Technologies

Journal Section

Research Article

Authors

Emrah Özakar ^*
0000-0002-7443-208X
Türkiye

Rukiye Sevinç Özakar
0000-0002-2972-8084
Türkiye

Mehmet Cemal Adigüzel
0000-0002-2385-9649
Türkiye

Publication Date

June 28, 2025

Submission Date

January 24, 2024

Acceptance Date

March 8, 2024

Published in Issue

Year 2024 Volume: 28 Number: 4

IZ

https://izlik.org/JA85DJ84PB

Cite

RIS / Bibtex

APA

Özakar, E., Sevinç Özakar, R., & Adigüzel, M. C. (2025). Boron nitride nanoparticles: Preparation, characterization, stability and evaluation of antibacterial activities. Journal of Research in Pharmacy, 28(4), 1188-1199. https://izlik.org/JA85DJ84PB

AMA

1.Özakar E, Sevinç Özakar R, Adigüzel MC. Boron nitride nanoparticles: Preparation, characterization, stability and evaluation of antibacterial activities. J. Res. Pharm. 2025;28(4):1188-1199. https://izlik.org/JA85DJ84PB

Chicago

Özakar, Emrah, Rukiye Sevinç Özakar, and Mehmet Cemal Adigüzel. 2025. “Boron Nitride Nanoparticles: Preparation, Characterization, Stability and Evaluation of Antibacterial Activities”. Journal of Research in Pharmacy 28 (4): 1188-99. https://izlik.org/JA85DJ84PB.

EndNote

Özakar E, Sevinç Özakar R, Adigüzel MC (July 1, 2025) Boron nitride nanoparticles: Preparation, characterization, stability and evaluation of antibacterial activities. Journal of Research in Pharmacy 28 4 1188–1199.

IEEE

[1]E. Özakar, R. Sevinç Özakar, and M. C. Adigüzel, “Boron nitride nanoparticles: Preparation, characterization, stability and evaluation of antibacterial activities”, J. Res. Pharm., vol. 28, no. 4, pp. 1188–1199, July 2025, [Online]. Available: https://izlik.org/JA85DJ84PB

ISNAD

Özakar, Emrah - Sevinç Özakar, Rukiye - Adigüzel, Mehmet Cemal. “Boron Nitride Nanoparticles: Preparation, Characterization, Stability and Evaluation of Antibacterial Activities”. Journal of Research in Pharmacy 28/4 (July 1, 2025): 1188-1199. https://izlik.org/JA85DJ84PB.

JAMA

1.Özakar E, Sevinç Özakar R, Adigüzel MC. Boron nitride nanoparticles: Preparation, characterization, stability and evaluation of antibacterial activities. J. Res. Pharm. 2025;28:1188–1199.

MLA

Özakar, Emrah, et al. “Boron Nitride Nanoparticles: Preparation, Characterization, Stability and Evaluation of Antibacterial Activities”. Journal of Research in Pharmacy, vol. 28, no. 4, July 2025, pp. 1188-99, https://izlik.org/JA85DJ84PB.

Vancouver

1.Emrah Özakar, Rukiye Sevinç Özakar, Mehmet Cemal Adigüzel. Boron nitride nanoparticles: Preparation, characterization, stability and evaluation of antibacterial activities. J. Res. Pharm. [Internet]. 2025 Jul. 1;28(4):1188-99. Available from: https://izlik.org/JA85DJ84PB