Effects of different sizes silica nanoparticle on the Effects of silica nanoparticles on the liver, kidney and brain in ratsliver, kidney and brain in rats: Biochemical and histopathological evaluation

Ülkü Çömelekoglu; Ebru Ballı; Serap Yalın; Pelin Eroğlu; Gulsen Bayrak; Selma Yaman; Fatma Söğüt

Effects of different sizes silica nanoparticle on the Effects of silica nanoparticles on the liver, kidney and brain in ratsliver, kidney and brain in rats: Biochemical and histopathological evaluation

Abstract

Silica is among the most popular nanoparticles. Large-scale production and use have increased the risk of human exposure to silica nanoparticles (SiO2NPs). This study aimed to investigate the toxic effects on the kidney, liver and brain of the SiO2NPs. Twenty eight male Wistar albino rats were divided into four groups (n=7 rats) as control (1 mL/day physiological saline administration for 28 day), 6 nm SiO2NP (6 nm, 150 μg/mL/day for 28 day), 20 nm SiO2NP (20 nm, 150 μg/mL/day for 28 day) and 50 nm SiO2NP (50 nm, 150 μg/mL/day for 28 day) groups. After the last administration, rats were sacrificed and kidney, liver and brain samples were taken for biochemical and histological investigation. In all groups, malondialdehyde (MDA) levels, superoxide dismutase (SOD) and catalase (CAT) activities were measured using the spectrophotometric methods. Ultrastructural changes of tissues were evaluated using transmission electron microscopy. In the kidney tissue, the MDA level significantly increased in the 6 and 50 nm groups, while the similar increase was observed in the 6 nm group of the liver and 20 and 50 nm groups of the brain. SOD activity significantly increased in the 6, 20 and 50 nm groups in brain and kidney tissues, but no significant change was observed in the liver tissue groups. Catalase activity decreased in the kidneys at 6 and 50 nm groups and increased in the 20 and 50 nm groups in liver and brain tissues. Ultrastructurally, kidney and liver tissues had normal morphological features in all groups. Degenerative changes were observed in the nerve fibers and axoplasm of myelinated and unmyelinated nerve fibers in 6 nM, 20 nM and 50 nM SiO2NP groups in the brain. These findings showed that exposure to 6, 20 and 50 nm sizes SiO2 NPs may cause toxic effects in the liver, kidney and brain.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Biochemistry

Journal Section

Research Article

Authors

Ülkü Çömelekoglu ^*
Türkiye

Ebru Ballı
Türkiye

Serap Yalın
Türkiye

Pelin Eroğlu
Türkiye

Gulsen Bayrak
Türkiye

Selma Yaman This is me
Türkiye

Fatma Söğüt
Türkiye

Publication Date

June 27, 2025

Submission Date

September 4, 2018

Acceptance Date

November 8, 2018

Published in Issue

Year 2019 Volume: 23 Number: 3

IZ

https://izlik.org/JA45UN62NJ

Cite

RIS / Bibtex

APA

Çömelekoglu, Ü., Ballı, E., Yalın, S., Eroğlu, P., Bayrak, G., Yaman, S., & Söğüt, F. (2025). Effects of different sizes silica nanoparticle on the Effects of silica nanoparticles on the liver, kidney and brain in ratsliver, kidney and brain in rats: Biochemical and histopathological evaluation. Journal of Research in Pharmacy, 23(3), 344-353. https://izlik.org/JA45UN62NJ

AMA

1.Çömelekoglu Ü, Ballı E, Yalın S, et al. Effects of different sizes silica nanoparticle on the Effects of silica nanoparticles on the liver, kidney and brain in ratsliver, kidney and brain in rats: Biochemical and histopathological evaluation. J. Res. Pharm. 2025;23(3):344-353. https://izlik.org/JA45UN62NJ

Chicago

Çömelekoglu, Ülkü, Ebru Ballı, Serap Yalın, et al. 2025. “Effects of Different Sizes Silica Nanoparticle on the Effects of Silica Nanoparticles on the Liver, Kidney and Brain in Ratsliver, Kidney and Brain in Rats: Biochemical and Histopathological Evaluation”. Journal of Research in Pharmacy 23 (3): 344-53. https://izlik.org/JA45UN62NJ.

EndNote

Çömelekoglu Ü, Ballı E, Yalın S, Eroğlu P, Bayrak G, Yaman S, Söğüt F (June 1, 2025) Effects of different sizes silica nanoparticle on the Effects of silica nanoparticles on the liver, kidney and brain in ratsliver, kidney and brain in rats: Biochemical and histopathological evaluation. Journal of Research in Pharmacy 23 3 344–353.

IEEE

[1]Ü. Çömelekoglu et al., “Effects of different sizes silica nanoparticle on the Effects of silica nanoparticles on the liver, kidney and brain in ratsliver, kidney and brain in rats: Biochemical and histopathological evaluation”, J. Res. Pharm., vol. 23, no. 3, pp. 344–353, June 2025, [Online]. Available: https://izlik.org/JA45UN62NJ

ISNAD

Çömelekoglu, Ülkü - Ballı, Ebru - Yalın, Serap - Eroğlu, Pelin - Bayrak, Gulsen - Yaman, Selma - Söğüt, Fatma. “Effects of Different Sizes Silica Nanoparticle on the Effects of Silica Nanoparticles on the Liver, Kidney and Brain in Ratsliver, Kidney and Brain in Rats: Biochemical and Histopathological Evaluation”. Journal of Research in Pharmacy 23/3 (June 1, 2025): 344-353. https://izlik.org/JA45UN62NJ.

JAMA

1.Çömelekoglu Ü, Ballı E, Yalın S, Eroğlu P, Bayrak G, Yaman S, Söğüt F. Effects of different sizes silica nanoparticle on the Effects of silica nanoparticles on the liver, kidney and brain in ratsliver, kidney and brain in rats: Biochemical and histopathological evaluation. J. Res. Pharm. 2025;23:344–353.

MLA

Çömelekoglu, Ülkü, et al. “Effects of Different Sizes Silica Nanoparticle on the Effects of Silica Nanoparticles on the Liver, Kidney and Brain in Ratsliver, Kidney and Brain in Rats: Biochemical and Histopathological Evaluation”. Journal of Research in Pharmacy, vol. 23, no. 3, June 2025, pp. 344-53, https://izlik.org/JA45UN62NJ.

Vancouver

1.Ülkü Çömelekoglu, Ebru Ballı, Serap Yalın, Pelin Eroğlu, Gulsen Bayrak, Selma Yaman, Fatma Söğüt. Effects of different sizes silica nanoparticle on the Effects of silica nanoparticles on the liver, kidney and brain in ratsliver, kidney and brain in rats: Biochemical and histopathological evaluation. J. Res. Pharm. [Internet]. 2025 Jun. 1;23(3):344-53. Available from: https://izlik.org/JA45UN62NJ