Development a taste-masked acetaminophen solid dispersions using Eudragit® E100 polymer by solvent evaporation technique

Sally Shahoud; Wassim Abdelwahed; Tamim Hammad

Development a taste-masked acetaminophen solid dispersions using Eudragit® E100 polymer by solvent evaporation technique

Abstract

The bitter taste of acetaminophen greatly reduced its formulation in oral dosage forms, so masking the taste was tested using the solid dispersion technique by Eudragit E100 and the solvent evaporation method. The obtained solid dispersions were characterized by FT-IR and DSC. Then, production yield, and drug loading have been determined, and the efficiency of this technique in taste masking by in vitro-in vivo evaluation were investigated by measuring the amount of drug released at pH=6.8 similar to saliva and pH=1.2 similar to stomach. FT-IR demonstrated that absence of interactions between drug and polymer and DSC results showed the complete formation of solid dispersion for F2 and partial formation with F1 and F3. Production yield was more than 96% for all formulations, and drug loading ranged between 99-103% and this increased with special dishes, while in vitro drug release results at pH=1.2 after 15min reached 84.95±0.55,100.89±0.70, and 95.78±0.71 (μg/ml) for F1, F2, and F3 respectively. In another hand, taste-masking evaluation at pH=6.8 showed drug release amount after 2min less than the determination bitterness threshold (900μg/ml) there were 114.98,75.97, and 10.26 μg/ml for F1, F2, and F3 respectively. Therefore, this technique is considered efficient in masking the taste with obtaining a good production yield.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacology and Pharmaceutical Sciences (Other)

Journal Section

Research Article

Authors

Sally Shahoud ^* This is me
0000-0001-9753-1606
Syria

Wassim Abdelwahed This is me
0000-0002-6353-8831
Syria

Tamim Hammad This is me
0000-0001-5234-1817
Syria

Publication Date

June 28, 2025

Submission Date

December 12, 2022

Acceptance Date

April 11, 2023

Published in Issue

Year 2023 Volume: 27 Number: 5

IZ

https://izlik.org/JA27DU99ME

Cite

RIS / Bibtex

APA

Shahoud, S., Abdelwahed, W., & Hammad, T. (2025). Development a taste-masked acetaminophen solid dispersions using Eudragit® E100 polymer by solvent evaporation technique. Journal of Research in Pharmacy, 27(5), 1998-2006. https://izlik.org/JA27DU99ME

AMA

1.Shahoud S, Abdelwahed W, Hammad T. Development a taste-masked acetaminophen solid dispersions using Eudragit® E100 polymer by solvent evaporation technique. J. Res. Pharm. 2025;27(5):1998-2006. https://izlik.org/JA27DU99ME

Chicago

Shahoud, Sally, Wassim Abdelwahed, and Tamim Hammad. 2025. “Development a Taste-Masked Acetaminophen Solid Dispersions Using Eudragit® E100 Polymer by Solvent Evaporation Technique”. Journal of Research in Pharmacy 27 (5): 1998-2006. https://izlik.org/JA27DU99ME.

EndNote

Shahoud S, Abdelwahed W, Hammad T (July 1, 2025) Development a taste-masked acetaminophen solid dispersions using Eudragit® E100 polymer by solvent evaporation technique. Journal of Research in Pharmacy 27 5 1998–2006.

IEEE

[1]S. Shahoud, W. Abdelwahed, and T. Hammad, “Development a taste-masked acetaminophen solid dispersions using Eudragit® E100 polymer by solvent evaporation technique”, J. Res. Pharm., vol. 27, no. 5, pp. 1998–2006, July 2025, [Online]. Available: https://izlik.org/JA27DU99ME

ISNAD

Shahoud, Sally - Abdelwahed, Wassim - Hammad, Tamim. “Development a Taste-Masked Acetaminophen Solid Dispersions Using Eudragit® E100 Polymer by Solvent Evaporation Technique”. Journal of Research in Pharmacy 27/5 (July 1, 2025): 1998-2006. https://izlik.org/JA27DU99ME.

JAMA

1.Shahoud S, Abdelwahed W, Hammad T. Development a taste-masked acetaminophen solid dispersions using Eudragit® E100 polymer by solvent evaporation technique. J. Res. Pharm. 2025;27:1998–2006.

MLA

Shahoud, Sally, et al. “Development a Taste-Masked Acetaminophen Solid Dispersions Using Eudragit® E100 Polymer by Solvent Evaporation Technique”. Journal of Research in Pharmacy, vol. 27, no. 5, July 2025, pp. 1998-06, https://izlik.org/JA27DU99ME.

Vancouver

1.Sally Shahoud, Wassim Abdelwahed, Tamim Hammad. Development a taste-masked acetaminophen solid dispersions using Eudragit® E100 polymer by solvent evaporation technique. J. Res. Pharm. [Internet]. 2025 Jul. 1;27(5):1998-2006. Available from: https://izlik.org/JA27DU99ME