Research Article

Electrochemical detection of anticancer drug lumazine and DNA interaction by using carbon nanotube modified electrodes

Volume: 23 Number: 4 June 27, 2025

Electrochemical detection of anticancer drug lumazine and DNA interaction by using carbon nanotube modified electrodes

Abstract

The interaction of lumazine (LMZ) with dsDNA was investigated with differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS) by using disposable carbon nanotubes-modified pencil graphite electrode (CNTs-PGE). The passive adsorption process was used to modify the electrode surface by CNTs and then dsDNA was immobilized onto the modified PGEs. The performance of CNT-PGEs was studied by examining the optimum analytical conditions with DPV and then impedance method was performed to characterize the modification of CNTs onto the electrode surface.

Keywords

References

  1. [1] Wang J. From DNA biosensors to gene chips. Nucl Acids Res. 2000; 28: 3011-3016. [CrossRef]
  2. [2] Palecek E, Fojta M. Detecting DNA hybridization and damage. Anal Chem. 2001; 73: 75A-83A. [CrossRef]
  3. [3] Erdem A. Nanomaterial-based electrochemical DNA sensing strategies. Talanta. 2007; 74: 318-325. [CrossRef]
  4. [4] Kuralay F, Karadeniz H, Muti M, Erdem A. Electrochemical DNA detection using carbon nanotubes. Curr Physical Chem. 2011; 1: 325-333. [CrossRef]
  5. [5] Erdem A, Ozsoz M. Electrochemical DNA Biosensors based on DNA‐Drug Interactions. Electroanalysis. 2002; 14: 965-974. [CrossRef]
  6. [6] Karadeniz H, Alparslan L, Erdem A, Karasulu E. Electrochemical investigation of interaction between Mitomycin C and DNA in a novel drug-delivery system. J Pharm Biomed Anal. 2007; 45: 322-326. [CrossRef]
  7. [7] Wang J, Ozsoz M, Cai X, Rivas G, Shiraishi H, Grant DH, Chicharro M, Fernandes J, Palecek E. Interactions of antitumor drug daunomycin with DNA in solution and at the surface. Bioelectrochem Bioenerg. 1998; 45: 33-40. [CrossRef]
  8. [8] Palecek E. From polarography of DNA to microanalysis with nucleic acid-modified electrodes. Electroanalysis. 1996; 8: 7-14. [CrossRef]

Details

Primary Language

English

Subjects

Pharmaceutical Analytical Chemistry

Journal Section

Research Article

Authors

Ece Ekşin
Türkiye

Arzum Erdem * This is me
Türkiye

Publication Date

June 27, 2025

Submission Date

October 26, 2018

Acceptance Date

April 13, 2019

Published in Issue

Year 2019 Volume: 23 Number: 4

APA
Karadeniz, H., Ekşin, E., & Erdem, A. (2025). Electrochemical detection of anticancer drug lumazine and DNA interaction by using carbon nanotube modified electrodes. Journal of Research in Pharmacy, 23(4), 682-688. https://izlik.org/JA87TK98XR
AMA
1.Karadeniz H, Ekşin E, Erdem A. Electrochemical detection of anticancer drug lumazine and DNA interaction by using carbon nanotube modified electrodes. J. Res. Pharm. 2025;23(4):682-688. https://izlik.org/JA87TK98XR
Chicago
Karadeniz, Hakan, Ece Ekşin, and Arzum Erdem. 2025. “Electrochemical Detection of Anticancer Drug Lumazine and DNA Interaction by Using Carbon Nanotube Modified Electrodes”. Journal of Research in Pharmacy 23 (4): 682-88. https://izlik.org/JA87TK98XR.
EndNote
Karadeniz H, Ekşin E, Erdem A (June 1, 2025) Electrochemical detection of anticancer drug lumazine and DNA interaction by using carbon nanotube modified electrodes. Journal of Research in Pharmacy 23 4 682–688.
IEEE
[1]H. Karadeniz, E. Ekşin, and A. Erdem, “Electrochemical detection of anticancer drug lumazine and DNA interaction by using carbon nanotube modified electrodes”, J. Res. Pharm., vol. 23, no. 4, pp. 682–688, June 2025, [Online]. Available: https://izlik.org/JA87TK98XR
ISNAD
Karadeniz, Hakan - Ekşin, Ece - Erdem, Arzum. “Electrochemical Detection of Anticancer Drug Lumazine and DNA Interaction by Using Carbon Nanotube Modified Electrodes”. Journal of Research in Pharmacy 23/4 (June 1, 2025): 682-688. https://izlik.org/JA87TK98XR.
JAMA
1.Karadeniz H, Ekşin E, Erdem A. Electrochemical detection of anticancer drug lumazine and DNA interaction by using carbon nanotube modified electrodes. J. Res. Pharm. 2025;23:682–688.
MLA
Karadeniz, Hakan, et al. “Electrochemical Detection of Anticancer Drug Lumazine and DNA Interaction by Using Carbon Nanotube Modified Electrodes”. Journal of Research in Pharmacy, vol. 23, no. 4, June 2025, pp. 682-8, https://izlik.org/JA87TK98XR.
Vancouver
1.Hakan Karadeniz, Ece Ekşin, Arzum Erdem. Electrochemical detection of anticancer drug lumazine and DNA interaction by using carbon nanotube modified electrodes. J. Res. Pharm. [Internet]. 2025 Jun. 1;23(4):682-8. Available from: https://izlik.org/JA87TK98XR