Electrochemical detection of anticancer drug lumazine and DNA interaction by using carbon nanotube modified electrodes
Abstract
The interaction of lumazine (LMZ) with dsDNA was investigated with differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS) by using disposable carbon nanotubes-modified pencil graphite electrode (CNTs-PGE). The passive adsorption process was used to modify the electrode surface by CNTs and then dsDNA was immobilized onto the modified PGEs. The performance of CNT-PGEs was studied by examining the optimum analytical conditions with DPV and then impedance method was performed to characterize the modification of CNTs onto the electrode surface.
Keywords
References
- [1] Wang J. From DNA biosensors to gene chips. Nucl Acids Res. 2000; 28: 3011-3016. [CrossRef]
- [2] Palecek E, Fojta M. Detecting DNA hybridization and damage. Anal Chem. 2001; 73: 75A-83A. [CrossRef]
- [3] Erdem A. Nanomaterial-based electrochemical DNA sensing strategies. Talanta. 2007; 74: 318-325. [CrossRef]
- [4] Kuralay F, Karadeniz H, Muti M, Erdem A. Electrochemical DNA detection using carbon nanotubes. Curr Physical Chem. 2011; 1: 325-333. [CrossRef]
- [5] Erdem A, Ozsoz M. Electrochemical DNA Biosensors based on DNA‐Drug Interactions. Electroanalysis. 2002; 14: 965-974. [CrossRef]
- [6] Karadeniz H, Alparslan L, Erdem A, Karasulu E. Electrochemical investigation of interaction between Mitomycin C and DNA in a novel drug-delivery system. J Pharm Biomed Anal. 2007; 45: 322-326. [CrossRef]
- [7] Wang J, Ozsoz M, Cai X, Rivas G, Shiraishi H, Grant DH, Chicharro M, Fernandes J, Palecek E. Interactions of antitumor drug daunomycin with DNA in solution and at the surface. Bioelectrochem Bioenerg. 1998; 45: 33-40. [CrossRef]
- [8] Palecek E. From polarography of DNA to microanalysis with nucleic acid-modified electrodes. Electroanalysis. 1996; 8: 7-14. [CrossRef]
Details
Primary Language
English
Subjects
Pharmaceutical Analytical Chemistry
Journal Section
Research Article
Publication Date
June 27, 2025
Submission Date
October 26, 2018
Acceptance Date
April 13, 2019
Published in Issue
Year 2019 Volume: 23 Number: 4
APA
Karadeniz, H., Ekşin, E., & Erdem, A. (2025). Electrochemical detection of anticancer drug lumazine and DNA interaction by using carbon nanotube modified electrodes. Journal of Research in Pharmacy, 23(4), 682-688. https://izlik.org/JA87TK98XR
AMA
1.Karadeniz H, Ekşin E, Erdem A. Electrochemical detection of anticancer drug lumazine and DNA interaction by using carbon nanotube modified electrodes. J. Res. Pharm. 2025;23(4):682-688. https://izlik.org/JA87TK98XR
Chicago
Karadeniz, Hakan, Ece Ekşin, and Arzum Erdem. 2025. “Electrochemical Detection of Anticancer Drug Lumazine and DNA Interaction by Using Carbon Nanotube Modified Electrodes”. Journal of Research in Pharmacy 23 (4): 682-88. https://izlik.org/JA87TK98XR.
EndNote
Karadeniz H, Ekşin E, Erdem A (June 1, 2025) Electrochemical detection of anticancer drug lumazine and DNA interaction by using carbon nanotube modified electrodes. Journal of Research in Pharmacy 23 4 682–688.
IEEE
[1]H. Karadeniz, E. Ekşin, and A. Erdem, “Electrochemical detection of anticancer drug lumazine and DNA interaction by using carbon nanotube modified electrodes”, J. Res. Pharm., vol. 23, no. 4, pp. 682–688, June 2025, [Online]. Available: https://izlik.org/JA87TK98XR
ISNAD
Karadeniz, Hakan - Ekşin, Ece - Erdem, Arzum. “Electrochemical Detection of Anticancer Drug Lumazine and DNA Interaction by Using Carbon Nanotube Modified Electrodes”. Journal of Research in Pharmacy 23/4 (June 1, 2025): 682-688. https://izlik.org/JA87TK98XR.
JAMA
1.Karadeniz H, Ekşin E, Erdem A. Electrochemical detection of anticancer drug lumazine and DNA interaction by using carbon nanotube modified electrodes. J. Res. Pharm. 2025;23:682–688.
MLA
Karadeniz, Hakan, et al. “Electrochemical Detection of Anticancer Drug Lumazine and DNA Interaction by Using Carbon Nanotube Modified Electrodes”. Journal of Research in Pharmacy, vol. 23, no. 4, June 2025, pp. 682-8, https://izlik.org/JA87TK98XR.
Vancouver
1.Hakan Karadeniz, Ece Ekşin, Arzum Erdem. Electrochemical detection of anticancer drug lumazine and DNA interaction by using carbon nanotube modified electrodes. J. Res. Pharm. [Internet]. 2025 Jun. 1;23(4):682-8. Available from: https://izlik.org/JA87TK98XR