Verapamil versus tamoxifen in treatment of experimentally induced infertility

Mohammed J Manna; Luma S Baqir; Haidar A Abdulamir

Verapamil versus tamoxifen in treatment of experimentally induced infertility

Abstract

Clinical and epidemiological studies indicated that there is an increased incidence of male infertility, with many cases that do not respond well to treatments. This study is aimed at evaluating the therapeutic effects of verapamil and tamoxifen against infertility, which may provide an essential strategy for the treatment of this disorder. A case-control study was conducted on 64 male albino rats, divided into four groups (16 for each); group A (control group); group B (infertile group that is induced by the ornidazole); and groups C and D, which are pretreated with verapamil and tamoxifen, respectively, in combination with ornidazole every day for four weeks. Serum levels of testosterone, follicle-stimulating hormone (FSH), luteinizing hormone (LH), glutathione (GSH), nitric oxide (NO), malondialdehyde (MDA), and superoxide dismutase (SOD) were assessed, and sperm parameters, including sperm count, sperm motility percentage, sperm morphology percentage, and sperm viability, were investigated. Furthermore, Motic Image Plus 2.0 ML was used to measure the mean diameter of the seminiferous tubules (SNT), and a morphometric analysis of 20 tubules per rat was also performed. The results revealed that both verapamil and tamoxifen provide a significant improvement in sperm count, motility, morphology, and dead sperm, with a significant improvement in testosterone, FSH, LH, GSH, NO, MDA, and SOD levels compared with the infertile group. Histophotometric results showed that verapamil and tamoxifen improved the number and size of SNT, Leydig cells, and Sertoli cell counts, which may indicate the promise of using these agents in the treatment of male infertility.

Keywords

References

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Details

Primary Language

English

Subjects

Medical Pharmacology

Journal Section

Research Article

Authors

Mohammed J Manna ^* This is me
0000-0001-5307-1361
Iraq

Luma S Baqir This is me
0000-0003-0807-6774
Iraq

Haidar A Abdulamir
Iraq

Publication Date

June 28, 2025

Submission Date

July 5, 2024

Acceptance Date

July 15, 2024

Published in Issue

Year 2024 Volume: 28 Number: 5

IZ

https://izlik.org/JA39KH54XA

Cite

RIS / Bibtex

APA

Manna, M. J., Baqir, L. S., & Abdulamir, H. A. (2025). Verapamil versus tamoxifen in treatment of experimentally induced infertility. Journal of Research in Pharmacy, 28(5), 1485-1491. https://izlik.org/JA39KH54XA

AMA

1.Manna MJ, Baqir LS, Abdulamir HA. Verapamil versus tamoxifen in treatment of experimentally induced infertility. J. Res. Pharm. 2025;28(5):1485-1491. https://izlik.org/JA39KH54XA

Chicago

Manna, Mohammed J, Luma S Baqir, and Haidar A Abdulamir. 2025. “Verapamil versus Tamoxifen in Treatment of Experimentally Induced Infertility”. Journal of Research in Pharmacy 28 (5): 1485-91. https://izlik.org/JA39KH54XA.

EndNote

Manna MJ, Baqir LS, Abdulamir HA (July 1, 2025) Verapamil versus tamoxifen in treatment of experimentally induced infertility. Journal of Research in Pharmacy 28 5 1485–1491.

IEEE

[1]M. J. Manna, L. S. Baqir, and H. A. Abdulamir, “Verapamil versus tamoxifen in treatment of experimentally induced infertility”, J. Res. Pharm., vol. 28, no. 5, pp. 1485–1491, July 2025, [Online]. Available: https://izlik.org/JA39KH54XA

ISNAD

Manna, Mohammed J - Baqir, Luma S - Abdulamir, Haidar A. “Verapamil versus Tamoxifen in Treatment of Experimentally Induced Infertility”. Journal of Research in Pharmacy 28/5 (July 1, 2025): 1485-1491. https://izlik.org/JA39KH54XA.

JAMA

1.Manna MJ, Baqir LS, Abdulamir HA. Verapamil versus tamoxifen in treatment of experimentally induced infertility. J. Res. Pharm. 2025;28:1485–1491.

MLA

Manna, Mohammed J, et al. “Verapamil versus Tamoxifen in Treatment of Experimentally Induced Infertility”. Journal of Research in Pharmacy, vol. 28, no. 5, July 2025, pp. 1485-91, https://izlik.org/JA39KH54XA.

Vancouver

1.Mohammed J Manna, Luma S Baqir, Haidar A Abdulamir. Verapamil versus tamoxifen in treatment of experimentally induced infertility. J. Res. Pharm. [Internet]. 2025 Jul. 1;28(5):1485-91. Available from: https://izlik.org/JA39KH54XA