Freeze dried multicomponent inclusion complexes of quercetin: Physicochemical evaluation and pharmacodynamic study

Anita Kulkarni; Remeth Dias; Vishwajeet Ghorpade

Freeze dried multicomponent inclusion complexes of quercetin: Physicochemical evaluation and pharmacodynamic study

Abstract

The present study was undertaken to investigate the effect of cyclodextrin (CD) complexation in presence of hydrophilic polymer on physicochemical properties as well as anti- inflammatory activity of quercetin (QUN). The initial phase solubility studies were carried out in presence and absence of hydrophilic polymers (hydroxypropylmethylcellulose, polyvinylpyrrolidone K30 and poloxamer 188) to study their effect on the stability and complexation efficiency of CDs. The binary (QUN-βCD and QUN-HPβCD) and multicomponent (QUN-βCD-POLO and QUN-HPβCD-POLO) inclusion complexes of QUN prepared using lyophilization technique. The complexes were subjected to DSC, ATR-FTIR, XRPD and SEM analysis, and evaluated for drug content and saturation solubility. The phase solubility studies revealed the formation of QUN-βCD and QUN-HPβCD complexes with 1:1 stoichiometry. The incorporation of POLO increased the stability as well as complexation efficiency of CDs. FTIR and DSC analysis indicated hydrogen bonding interaction POLO with QUN and CDs. XRD and SEM analysis revealed greater amorphization in case of multicomponent inclusion complexes. All complexes showed uniform drug content. QUN HPβCD-POLO exhibited maximum solubility than the physical mixtures and other complexes. The pure QUN and QUN-HPβCD-POLO were tested for in vivo anti-inflammatory activity by Carrageenan induced rat paw edema method. QUN-HPβCD-POLO exhibited significant increase in anti-inflammatory activity as compared to pure QUN.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Chemistry

Journal Section

Research Article

Authors

Anita Kulkarni This is me
India

Remeth Dias ^* This is me
India

Vishwajeet Ghorpade This is me
India

Publication Date

June 27, 2025

Submission Date

September 21, 2018

Acceptance Date

November 19, 2018

Published in Issue

Year 2019 Volume: 23 Number: 3

IZ

https://izlik.org/JA72ZM43BP

Cite

RIS / Bibtex

APA

Kulkarni, A., Dias, R., & Ghorpade, V. (2025). Freeze dried multicomponent inclusion complexes of quercetin: Physicochemical evaluation and pharmacodynamic study. Journal of Research in Pharmacy, 23(3), 403-414. https://izlik.org/JA72ZM43BP

AMA

1.Kulkarni A, Dias R, Ghorpade V. Freeze dried multicomponent inclusion complexes of quercetin: Physicochemical evaluation and pharmacodynamic study. J. Res. Pharm. 2025;23(3):403-414. https://izlik.org/JA72ZM43BP

Chicago

Kulkarni, Anita, Remeth Dias, and Vishwajeet Ghorpade. 2025. “Freeze Dried Multicomponent Inclusion Complexes of Quercetin: Physicochemical Evaluation and Pharmacodynamic Study”. Journal of Research in Pharmacy 23 (3): 403-14. https://izlik.org/JA72ZM43BP.

EndNote

Kulkarni A, Dias R, Ghorpade V (June 1, 2025) Freeze dried multicomponent inclusion complexes of quercetin: Physicochemical evaluation and pharmacodynamic study. Journal of Research in Pharmacy 23 3 403–414.

IEEE

[1]A. Kulkarni, R. Dias, and V. Ghorpade, “Freeze dried multicomponent inclusion complexes of quercetin: Physicochemical evaluation and pharmacodynamic study”, J. Res. Pharm., vol. 23, no. 3, pp. 403–414, June 2025, [Online]. Available: https://izlik.org/JA72ZM43BP

ISNAD

Kulkarni, Anita - Dias, Remeth - Ghorpade, Vishwajeet. “Freeze Dried Multicomponent Inclusion Complexes of Quercetin: Physicochemical Evaluation and Pharmacodynamic Study”. Journal of Research in Pharmacy 23/3 (June 1, 2025): 403-414. https://izlik.org/JA72ZM43BP.

JAMA

1.Kulkarni A, Dias R, Ghorpade V. Freeze dried multicomponent inclusion complexes of quercetin: Physicochemical evaluation and pharmacodynamic study. J. Res. Pharm. 2025;23:403–414.

MLA

Kulkarni, Anita, et al. “Freeze Dried Multicomponent Inclusion Complexes of Quercetin: Physicochemical Evaluation and Pharmacodynamic Study”. Journal of Research in Pharmacy, vol. 23, no. 3, June 2025, pp. 403-14, https://izlik.org/JA72ZM43BP.

Vancouver

1.Anita Kulkarni, Remeth Dias, Vishwajeet Ghorpade. Freeze dried multicomponent inclusion complexes of quercetin: Physicochemical evaluation and pharmacodynamic study. J. Res. Pharm. [Internet]. 2025 Jun. 1;23(3):403-14. Available from: https://izlik.org/JA72ZM43BP