Neusilin based liquisolid compacts of albendazole: Design, development, characterization and in vitro anthelmintic activity İD İD

Year 2019, Volume: 23 Issue: 3, 441 - 456, 27.06.2025

Amol Shete Ashwini Salunkhe Adhikrao Yadav , Sfurti Sakhare Rajendra Doijad

Abstract

The present investigation deals with enhancement of dissolution rate of high dose drug albendazole (ABZ)
using liquisolid compacts. Study of precompression characteristics, influence of excipients on drug release
characteristics and to compare drug release profile of the formulated liquisolid compacts with the directly compressible
laboratory made formulation. Liquisolid compacts were prepared by using three by twofactorial designs and evaluated
for differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), in vitro nthelmintic, in vitro antifungal
study and in vitro dissolution study. There was improvement in the dissolution rate and solubility was attributed to
decreased melting point and crystallinity of albendazole. In vitro anthelmintic and antifungal activities of neusilin based
liquisolid compacts were more than pure albendazole. The drug content of liquisolid compacts was not affected when
stored at room temperature for a period of 3 months. This study also provided evidence that it is possible to load high
amounts of drug into liquisolid compacts due to the neusilin allows higher liquid adsorption capacities. Neusilin based
technique is useful for the preparation of liquisolid compacts of high dose drug like albendazole with enhancement in
dissolution rate

Keywords

Albendazole , dissolution , liquisolid , compacts

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