Neusilin based liquisolid compacts of albendazole: Design, development, characterization and in vitro anthelmintic activity İD İD

Amol Shete; Ashwini Salunkhe; Adhikrao Yadav; Sfurti Sakhare; Rajendra Doijad

Neusilin based liquisolid compacts of albendazole: Design, development, characterization and in vitro anthelmintic activity İD İD

Abstract

The present investigation deals with enhancement of dissolution rate of high dose drug albendazole (ABZ) using liquisolid compacts. Study of precompression characteristics, influence of excipients on drug release characteristics and to compare drug release profile of the formulated liquisolid compacts with the directly compressible laboratory made formulation. Liquisolid compacts were prepared by using three by twofactorial designs and evaluated for differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), in vitro nthelmintic, in vitro antifungal study and in vitro dissolution study. There was improvement in the dissolution rate and solubility was attributed to decreased melting point and crystallinity of albendazole. In vitro anthelmintic and antifungal activities of neusilin based liquisolid compacts were more than pure albendazole. The drug content of liquisolid compacts was not affected when stored at room temperature for a period of 3 months. This study also provided evidence that it is possible to load high amounts of drug into liquisolid compacts due to the neusilin allows higher liquid adsorption capacities. Neusilin based technique is useful for the preparation of liquisolid compacts of high dose drug like albendazole with enhancement in dissolution rate

Keywords

References

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Details

Primary Language

English

Subjects

Basic Pharmacology

Journal Section

Research Article

Authors

Amol Shete ^* This is me
India

Ashwini Salunkhe This is me
India

Adhikrao Yadav
India

Sfurti Sakhare This is me
India

Rajendra Doijad This is me
India

Publication Date

June 27, 2025

Submission Date

November 17, 2018

Acceptance Date

February 7, 2019

Published in Issue

Year 2019 Volume: 23 Number: 3

IZ

https://izlik.org/JA42ZX76ZR

Cite

RIS / Bibtex

APA

Shete, A., Salunkhe, A., Yadav, A., Sakhare, S., & Doijad, R. (2025). Neusilin based liquisolid compacts of albendazole: Design, development, characterization and in vitro anthelmintic activity İD İD. Journal of Research in Pharmacy, 23(3), 441-456. https://izlik.org/JA42ZX76ZR

AMA

1.Shete A, Salunkhe A, Yadav A, Sakhare S, Doijad R. Neusilin based liquisolid compacts of albendazole: Design, development, characterization and in vitro anthelmintic activity İD İD. J. Res. Pharm. 2025;23(3):441-456. https://izlik.org/JA42ZX76ZR

Chicago

Shete, Amol, Ashwini Salunkhe, Adhikrao Yadav, Sfurti Sakhare, and Rajendra Doijad. 2025. “Neusilin Based Liquisolid Compacts of Albendazole: Design, Development, Characterization and in Vitro Anthelmintic Activity İD İD”. Journal of Research in Pharmacy 23 (3): 441-56. https://izlik.org/JA42ZX76ZR.

EndNote

Shete A, Salunkhe A, Yadav A, Sakhare S, Doijad R (June 1, 2025) Neusilin based liquisolid compacts of albendazole: Design, development, characterization and in vitro anthelmintic activity İD İD. Journal of Research in Pharmacy 23 3 441–456.

IEEE

[1]A. Shete, A. Salunkhe, A. Yadav, S. Sakhare, and R. Doijad, “Neusilin based liquisolid compacts of albendazole: Design, development, characterization and in vitro anthelmintic activity İD İD”, J. Res. Pharm., vol. 23, no. 3, pp. 441–456, June 2025, [Online]. Available: https://izlik.org/JA42ZX76ZR

ISNAD

Shete, Amol - Salunkhe, Ashwini - Yadav, Adhikrao - Sakhare, Sfurti - Doijad, Rajendra. “Neusilin Based Liquisolid Compacts of Albendazole: Design, Development, Characterization and in Vitro Anthelmintic Activity İD İD”. Journal of Research in Pharmacy 23/3 (June 1, 2025): 441-456. https://izlik.org/JA42ZX76ZR.

JAMA

1.Shete A, Salunkhe A, Yadav A, Sakhare S, Doijad R. Neusilin based liquisolid compacts of albendazole: Design, development, characterization and in vitro anthelmintic activity İD İD. J. Res. Pharm. 2025;23:441–456.

MLA

Shete, Amol, et al. “Neusilin Based Liquisolid Compacts of Albendazole: Design, Development, Characterization and in Vitro Anthelmintic Activity İD İD”. Journal of Research in Pharmacy, vol. 23, no. 3, June 2025, pp. 441-56, https://izlik.org/JA42ZX76ZR.

Vancouver

1.Amol Shete, Ashwini Salunkhe, Adhikrao Yadav, Sfurti Sakhare, Rajendra Doijad. Neusilin based liquisolid compacts of albendazole: Design, development, characterization and in vitro anthelmintic activity İD İD. J. Res. Pharm. [Internet]. 2025 Jun. 1;23(3):441-56. Available from: https://izlik.org/JA42ZX76ZR