Development of biosynthesized silver nanoparticles from Cinnamomum tamala for anti-oxidant, anti-microbial and anti-cancer activity

Laxman Vıjapur; Y Srinivas; Anita Desai; Avinash S Gudigennavar; Somalingeshwar Siddramshettar; Pooja Yaragattimath

Development of biosynthesized silver nanoparticles from Cinnamomum tamala for anti-oxidant, anti-microbial and anti-cancer activity

Abstract

Purpose: The purpose of this study was to determine the effect of biosynthesized silver nanoparticles (AgNPs) from Cinnamomum tamala aqueous extract (CTAE) for antioxidant, antimicrobial and anticancer activity. Experimental approach: Biosynthesis of AgNPs was successfully achieved by using CTAE by eco-friendly and a cheaper method. In this study we used CTAE for biosynthesis, which reduces silver ions into AgNPs. The obtained AgNPs were characterized by UV, FTIR, DLS, TEM and EDAX analysis. They were further analyzed for their anti- oxidant, anti-microbial, anti-cancer activities. Key results: The presence of biosynthesized AgNPs (422nm) was confirmed by UV-visible spectroscopy. FT-IR spectrum was used to confirm the presence of different functional groups in the biomolecules which were responsible for capping & reducing of the nanoparticles. Dynamic light scattering of the prepared formulations revealed all the formulations were in nano- range, F1 showed the mean particle size 239.1nm.TEM Analysis revealed that the size of the particleswere in nano-range of 20.38nm and presence of silver was confirmed through EDAX. The IC50 value of F1 indicated 91.30µg/ml for H2O2 scavenging activity and 102.43µg/ml for DPPH scavenging activity. Biosynthesized AgNPs (F1) showed good antimicrobial activity against two gram negative bacteria and one gram positive bacteria. MTT assay of optimized formulation F1 was compared with CTAE showed significant antiproliferative activity against A375 cancer cell line with IC50 for CTAE was 47.24µg/ml, where as for biosynthesized AgNPs the IC50 was 22µg/ml. Apoptosis studies of formulation F1 showed higher early apoptosis as compared to CTAE. Conclusion: The biosynthesized silver nanoparticles (F1) showed good antioxidant activity, antimicrobial activity and anti cancer activity compared to CTAE.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacognosy

Journal Section

Research Article

Authors

Laxman Vıjapur ^*
0000-0003-2043-8862
India

Y Srinivas
0000-0002-8472-0958
India

Anita Desai
0000-0003-1032-2604
India

Avinash S Gudigennavar This is me
0000-0001-7099-5857
India

Somalingeshwar Siddramshettar
0000-0001-7648-6666
India

Pooja Yaragattimath This is me
0000-0003-3851-7497
India

Publication Date

June 27, 2025

Submission Date

September 8, 2022

Acceptance Date

October 21, 2022

Published in Issue

Year 2023 Volume: 27 Number: 2

IZ

https://izlik.org/JA84CK38SK

Cite

RIS / Bibtex

APA

Vıjapur, L., Srinivas, Y., Desai, A., Gudigennavar, A. S., Siddramshettar, S., & Yaragattimath, P. (2025). Development of biosynthesized silver nanoparticles from Cinnamomum tamala for anti-oxidant, anti-microbial and anti-cancer activity. Journal of Research in Pharmacy, 27(2), 769-782. https://izlik.org/JA84CK38SK

AMA

1.Vıjapur L, Srinivas Y, Desai A, Gudigennavar AS, Siddramshettar S, Yaragattimath P. Development of biosynthesized silver nanoparticles from Cinnamomum tamala for anti-oxidant, anti-microbial and anti-cancer activity. J. Res. Pharm. 2025;27(2):769-782. https://izlik.org/JA84CK38SK

Chicago

Vıjapur, Laxman, Y Srinivas, Anita Desai, Avinash S Gudigennavar, Somalingeshwar Siddramshettar, and Pooja Yaragattimath. 2025. “Development of Biosynthesized Silver Nanoparticles from Cinnamomum Tamala for Anti-Oxidant, Anti-Microbial and Anti-Cancer Activity”. Journal of Research in Pharmacy 27 (2): 769-82. https://izlik.org/JA84CK38SK.

EndNote

Vıjapur L, Srinivas Y, Desai A, Gudigennavar AS, Siddramshettar S, Yaragattimath P (June 1, 2025) Development of biosynthesized silver nanoparticles from Cinnamomum tamala for anti-oxidant, anti-microbial and anti-cancer activity. Journal of Research in Pharmacy 27 2 769–782.

IEEE

[1]L. Vıjapur, Y. Srinivas, A. Desai, A. S. Gudigennavar, S. Siddramshettar, and P. Yaragattimath, “Development of biosynthesized silver nanoparticles from Cinnamomum tamala for anti-oxidant, anti-microbial and anti-cancer activity”, J. Res. Pharm., vol. 27, no. 2, pp. 769–782, June 2025, [Online]. Available: https://izlik.org/JA84CK38SK

ISNAD

Vıjapur, Laxman - Srinivas, Y - Desai, Anita - Gudigennavar, Avinash S - Siddramshettar, Somalingeshwar - Yaragattimath, Pooja. “Development of Biosynthesized Silver Nanoparticles from Cinnamomum Tamala for Anti-Oxidant, Anti-Microbial and Anti-Cancer Activity”. Journal of Research in Pharmacy 27/2 (June 1, 2025): 769-782. https://izlik.org/JA84CK38SK.

JAMA

1.Vıjapur L, Srinivas Y, Desai A, Gudigennavar AS, Siddramshettar S, Yaragattimath P. Development of biosynthesized silver nanoparticles from Cinnamomum tamala for anti-oxidant, anti-microbial and anti-cancer activity. J. Res. Pharm. 2025;27:769–782.

MLA

Vıjapur, Laxman, et al. “Development of Biosynthesized Silver Nanoparticles from Cinnamomum Tamala for Anti-Oxidant, Anti-Microbial and Anti-Cancer Activity”. Journal of Research in Pharmacy, vol. 27, no. 2, June 2025, pp. 769-82, https://izlik.org/JA84CK38SK.

Vancouver

1.Laxman Vıjapur, Y Srinivas, Anita Desai, Avinash S Gudigennavar, Somalingeshwar Siddramshettar, Pooja Yaragattimath. Development of biosynthesized silver nanoparticles from Cinnamomum tamala for anti-oxidant, anti-microbial and anti-cancer activity. J. Res. Pharm. [Internet]. 2025 Jun. 1;27(2):769-82. Available from: https://izlik.org/JA84CK38SK