Employment of liquisolid approach in the development optimization and evaluation of an oral disintegrating tablet of aripiprazole

Vishranth N; P Sudheer; Darshan P R; Venkatesh Prasad S; Imran Pasha

Employment of liquisolid approach in the development optimization and evaluation of an oral disintegrating tablet of aripiprazole

Abstract

The major problems associated with the oral route of administration are low solubility, low permeability, and hepatic degradation of drugs, leading to low bioavailability issues. Therefore, in this study, a biopharmaceutics classification systems (BCS) class II drug aripiprazole was chosen to develop an oral disintegrating tablet using liquisolid technology to enhance the solubility and dissolution rate of the drug. Liquisolid compact of aripiprazole was prepared using polyethylene glycol (PEG 400) as a nonvolatile solvent, microcrystalline cellulose (MCC) as a carrier, and Aerosil 200 as a coating material. The formulations were optimized via the 23-factorial design. The optimum formulation was further converted to oral disintegrating tablets with the help of the super disintegrant, cross povidone, and the produced tablets were evaluated. The water solubility of aripiprazole was observed to have increased from 4.5µg/ml to 0.13mg/ml in the liquisolid form and angle of repose was found to be reasonably passable. As was observed from the experimental design, the solvent, solvent: carrier, and carrier were seen to have a significant influence on the selected responses. The X-ray diffraction pattern of the optimized formula indicated a reduction in the peak number and the peak intensities compared to the pure drug. The tablets prepared of liquisolid compacts displayed good tableting properties. The disintegration time was found to be 40 seconds. The stability studies indicated no apparent changes in the properties after a storage period of 3 months. The liquisolid compacts are an inexpensive method of preparing oral disintegrating tablets of Aripiprazole with an assurance of suitable dissolution property of the drug.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacology and Pharmaceutical Sciences (Other)

Journal Section

Research Article

Authors

Vishranth N This is me
0000-0002-5608-5029
India

P Sudheer ^*
0000-0002-7041-8993
India

Darshan P R This is me
0000-0002-7394-6986
India

Venkatesh Prasad S This is me
0000-0003-3360-5711
India

Imran Pasha This is me
0000-0003-3324-3810
India

Publication Date

June 27, 2025

Submission Date

September 12, 2022

Acceptance Date

November 21, 2022

Published in Issue

Year 2023 Volume: 27 Number: 2

IZ

https://izlik.org/JA97EA54ZT

Cite

RIS / Bibtex

APA

N, V., Sudheer, P., P R, D., S, V. P., & Pasha, I. (2025). Employment of liquisolid approach in the development optimization and evaluation of an oral disintegrating tablet of aripiprazole. Journal of Research in Pharmacy, 27(2), 811-824. https://izlik.org/JA97EA54ZT

AMA

1.N V, Sudheer P, P R D, S VP, Pasha I. Employment of liquisolid approach in the development optimization and evaluation of an oral disintegrating tablet of aripiprazole. J. Res. Pharm. 2025;27(2):811-824. https://izlik.org/JA97EA54ZT

Chicago

N, Vishranth, P Sudheer, Darshan P R, Venkatesh Prasad S, and Imran Pasha. 2025. “Employment of Liquisolid Approach in the Development Optimization and Evaluation of an Oral Disintegrating Tablet of Aripiprazole”. Journal of Research in Pharmacy 27 (2): 811-24. https://izlik.org/JA97EA54ZT.

EndNote

N V, Sudheer P, P R D, S VP, Pasha I (June 1, 2025) Employment of liquisolid approach in the development optimization and evaluation of an oral disintegrating tablet of aripiprazole. Journal of Research in Pharmacy 27 2 811–824.

IEEE

[1]V. N, P. Sudheer, D. P R, V. P. S, and I. Pasha, “Employment of liquisolid approach in the development optimization and evaluation of an oral disintegrating tablet of aripiprazole”, J. Res. Pharm., vol. 27, no. 2, pp. 811–824, June 2025, [Online]. Available: https://izlik.org/JA97EA54ZT

ISNAD

N, Vishranth - Sudheer, P - P R, Darshan - S, Venkatesh Prasad - Pasha, Imran. “Employment of Liquisolid Approach in the Development Optimization and Evaluation of an Oral Disintegrating Tablet of Aripiprazole”. Journal of Research in Pharmacy 27/2 (June 1, 2025): 811-824. https://izlik.org/JA97EA54ZT.

JAMA

1.N V, Sudheer P, P R D, S VP, Pasha I. Employment of liquisolid approach in the development optimization and evaluation of an oral disintegrating tablet of aripiprazole. J. Res. Pharm. 2025;27:811–824.

MLA

N, Vishranth, et al. “Employment of Liquisolid Approach in the Development Optimization and Evaluation of an Oral Disintegrating Tablet of Aripiprazole”. Journal of Research in Pharmacy, vol. 27, no. 2, June 2025, pp. 811-24, https://izlik.org/JA97EA54ZT.

Vancouver

1.Vishranth N, P Sudheer, Darshan P R, Venkatesh Prasad S, Imran Pasha. Employment of liquisolid approach in the development optimization and evaluation of an oral disintegrating tablet of aripiprazole. J. Res. Pharm. [Internet]. 2025 Jun. 1;27(2):811-24. Available from: https://izlik.org/JA97EA54ZT