Investigation of the protective and therapeutic efficacy of Myrtus communis extract in aluminum chloride and D-galactose-induced Alzheimer's disease in rats

Kübra Yalman; Ali Şen; Ozge Cevik; Beril Kadıoğlu Yaman; Büşra Ertaş; Sıla Yildiz; Göksel Şener

Investigation of the protective and therapeutic efficacy of Myrtus communis extract in aluminum chloride and D-galactose-induced Alzheimer's disease in rats

Abstract

This study investigated the possible protective and therapeutic effects of Myrtus communis subsp. communis ethanol extract (MC) in aluminum chloride (AlCl3) and D-galactose (D-Gal) induced Alzheimer's disease in rats. MC was orally given to rats as a protective treatment for 90 days and, in other two groups starting from the 60th day MC (100-200 mg/kg) was administered, concomitantly with AlCl3 and D-Gal. Learning and memory functions were evaluated by the behavioral tests. Biological activities of MC treatment were examined in hippocampal tissues by ELISA tests. D-Gal and AlCl3-treated rats showed increased amyloid beta (Aβ) and 8-hydroxy-2-deoxyguanosine (8-OHdG) levels, acetylcholinesterase activity and decreased neprilysin, Na+-K+ATPase and SOD levels in parallel with a decrease in Novel Object Recognition Test, Morris Water Maze and Passive Avoidance Test scores. On the other hand, MC administration reversed the behavioral impairments and improved learning and memory. Moreover, MC treatment decreased Aβ and 8-OHdG levels and acetylcholinesterase activity and increased neprilysin levels, Na+-K+ATPase and SOD levels. Our results suggest that MC has beneficial effects on cognitive and neuronal functions through its anticholinesterase and antioxidant properties.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacology and Pharmaceutical Sciences (Other)

Journal Section

Research Article

Authors

Kübra Yalman This is me
0000-0002-7059-812X
Türkiye

Ali Şen
0000-0002-2144-5741
Türkiye

Ozge Cevik
Türkiye

Beril Kadıoğlu Yaman
0000-0001-8887-4826
Türkiye

Büşra Ertaş
0000-0001-8374-1098
Türkiye

Sıla Yildiz This is me
Türkiye

Göksel Şener ^*
0000-0001-7444-6193
Türkiye

Publication Date

June 28, 2025

Submission Date

June 27, 2022

Acceptance Date

July 15, 2022

Published in Issue

Year 2022 Volume: 26 Number: 5

IZ

https://izlik.org/JA54XP56WE

Cite

RIS / Bibtex

APA

Yalman, K., Şen, A., Cevik, O., Kadıoğlu Yaman, B., Ertaş, B., Yildiz, S., & Şener, G. (2025). Investigation of the protective and therapeutic efficacy of Myrtus communis extract in aluminum chloride and D-galactose-induced Alzheimer’s disease in rats. Journal of Research in Pharmacy, 26(5), 1363-1374. https://izlik.org/JA54XP56WE

AMA

1.Yalman K, Şen A, Cevik O, et al. Investigation of the protective and therapeutic efficacy of Myrtus communis extract in aluminum chloride and D-galactose-induced Alzheimer’s disease in rats. J. Res. Pharm. 2025;26(5):1363-1374. https://izlik.org/JA54XP56WE

Chicago

Yalman, Kübra, Ali Şen, Ozge Cevik, et al. 2025. “Investigation of the Protective and Therapeutic Efficacy of Myrtus Communis Extract in Aluminum Chloride and D-Galactose-Induced Alzheimer’s Disease in Rats”. Journal of Research in Pharmacy 26 (5): 1363-74. https://izlik.org/JA54XP56WE.

EndNote

Yalman K, Şen A, Cevik O, Kadıoğlu Yaman B, Ertaş B, Yildiz S, Şener G (June 1, 2025) Investigation of the protective and therapeutic efficacy of Myrtus communis extract in aluminum chloride and D-galactose-induced Alzheimer’s disease in rats. Journal of Research in Pharmacy 26 5 1363–1374.

IEEE

[1]K. Yalman et al., “Investigation of the protective and therapeutic efficacy of Myrtus communis extract in aluminum chloride and D-galactose-induced Alzheimer’s disease in rats”, J. Res. Pharm., vol. 26, no. 5, pp. 1363–1374, June 2025, [Online]. Available: https://izlik.org/JA54XP56WE

ISNAD

Yalman, Kübra - Şen, Ali - Cevik, Ozge - Kadıoğlu Yaman, Beril - Ertaş, Büşra - Yildiz, Sıla - Şener, Göksel. “Investigation of the Protective and Therapeutic Efficacy of Myrtus Communis Extract in Aluminum Chloride and D-Galactose-Induced Alzheimer’s Disease in Rats”. Journal of Research in Pharmacy 26/5 (June 1, 2025): 1363-1374. https://izlik.org/JA54XP56WE.

JAMA

1.Yalman K, Şen A, Cevik O, Kadıoğlu Yaman B, Ertaş B, Yildiz S, Şener G. Investigation of the protective and therapeutic efficacy of Myrtus communis extract in aluminum chloride and D-galactose-induced Alzheimer’s disease in rats. J. Res. Pharm. 2025;26:1363–1374.

MLA

Yalman, Kübra, et al. “Investigation of the Protective and Therapeutic Efficacy of Myrtus Communis Extract in Aluminum Chloride and D-Galactose-Induced Alzheimer’s Disease in Rats”. Journal of Research in Pharmacy, vol. 26, no. 5, June 2025, pp. 1363-74, https://izlik.org/JA54XP56WE.

Vancouver

1.Kübra Yalman, Ali Şen, Ozge Cevik, Beril Kadıoğlu Yaman, Büşra Ertaş, Sıla Yildiz, Göksel Şener. Investigation of the protective and therapeutic efficacy of Myrtus communis extract in aluminum chloride and D-galactose-induced Alzheimer’s disease in rats. J. Res. Pharm. [Internet]. 2025 Jun. 1;26(5):1363-74. Available from: https://izlik.org/JA54XP56WE