Strategic application of a mixed polymeric micellar solid dispersion system to domperidone for improved biopharmaceutical characteristics

Shimul Halder; M. A. K. Azad; Md. Shamiul Islam; Istiak Hossen; Lata Shuma; Eva Rahman Kabir

Strategic application of a mixed polymeric micellar solid dispersion system to domperidone for improved biopharmaceutical characteristics

Abstract

The main objective of this work was to improve the biopharmaceutical properties of Domperidone (DMP)- loaded mixed polymeric micellar solid dispersion (MMSD). The apparent solubility of DMP in polymer solutions was used to choose suitable amphiphilic polymers for the preparation of an MMSD system. Different ratios of Soluplus® and Kolliphor® P188 (ranging 0–80 %w/w) have been used to prepare the MMSD-DMP by solvent evaporation method and physicochemically characterized. Among the tested different ratios of Soluplus® and Kolliphor® P188, the optimal ratio of polymers was selected based on the solubility and surface properties. The solubility of optimized MMSD-DMP in water was found more than 17 times higher compared to that of the crystalline DMP. The crystallinity evaluations of the optimized formulation revealed amorphization of DMP, resulting in enhanced solubility. The drug release pattern did not change significantly between formulations of MMSD-DMP produced by rotary vacuum drying and freeze drying. From these findings, MMSD approach might be a promising dosage option for DMP, offering enhanced biopharmaceutical behaviors leading to improved oral absorption.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Biotechnology

Journal Section

Research Article

Authors

Shimul Halder ^* This is me
0000-0002-8445-2965
Bangladesh

M. A. K. Azad This is me
0000-0002-1493-8433
Bangladesh

Md. Shamiul Islam This is me
0000-0002-8835-3024
Bangladesh

Istiak Hossen This is me
0000-0002-4154-7278
Bangladesh

Lata Shuma This is me
0000-0001-7661-7857
Bangladesh

Eva Rahman Kabir This is me
0000-0001-9016-0865
Bangladesh

Publication Date

June 27, 2025

Submission Date

July 31, 2022

Acceptance Date

November 13, 2022

Published in Issue

Year 2023 Volume: 27 Number: 2

IZ

https://izlik.org/JA77GX55SG

Cite

RIS / Bibtex

APA

Halder, S., Azad, M. A. K., Islam, M. S., Hossen, I., Shuma, L., & Kabir, E. R. (2025). Strategic application of a mixed polymeric micellar solid dispersion system to domperidone for improved biopharmaceutical characteristics. Journal of Research in Pharmacy, 27(2), 860-872. https://izlik.org/JA77GX55SG

AMA

1.Halder S, Azad MAK, Islam MS, Hossen I, Shuma L, Kabir ER. Strategic application of a mixed polymeric micellar solid dispersion system to domperidone for improved biopharmaceutical characteristics. J. Res. Pharm. 2025;27(2):860-872. https://izlik.org/JA77GX55SG

Chicago

Halder, Shimul, M. A. K. Azad, Md. Shamiul Islam, Istiak Hossen, Lata Shuma, and Eva Rahman Kabir. 2025. “Strategic Application of a Mixed Polymeric Micellar Solid Dispersion System to Domperidone for Improved Biopharmaceutical Characteristics”. Journal of Research in Pharmacy 27 (2): 860-72. https://izlik.org/JA77GX55SG.

EndNote

Halder S, Azad MAK, Islam MS, Hossen I, Shuma L, Kabir ER (June 1, 2025) Strategic application of a mixed polymeric micellar solid dispersion system to domperidone for improved biopharmaceutical characteristics. Journal of Research in Pharmacy 27 2 860–872.

IEEE

[1]S. Halder, M. A. K. Azad, M. S. Islam, I. Hossen, L. Shuma, and E. R. Kabir, “Strategic application of a mixed polymeric micellar solid dispersion system to domperidone for improved biopharmaceutical characteristics”, J. Res. Pharm., vol. 27, no. 2, pp. 860–872, June 2025, [Online]. Available: https://izlik.org/JA77GX55SG

ISNAD

Halder, Shimul - Azad, M. A. K. - Islam, Md. Shamiul - Hossen, Istiak - Shuma, Lata - Kabir, Eva Rahman. “Strategic Application of a Mixed Polymeric Micellar Solid Dispersion System to Domperidone for Improved Biopharmaceutical Characteristics”. Journal of Research in Pharmacy 27/2 (June 1, 2025): 860-872. https://izlik.org/JA77GX55SG.

JAMA

1.Halder S, Azad MAK, Islam MS, Hossen I, Shuma L, Kabir ER. Strategic application of a mixed polymeric micellar solid dispersion system to domperidone for improved biopharmaceutical characteristics. J. Res. Pharm. 2025;27:860–872.

MLA

Halder, Shimul, et al. “Strategic Application of a Mixed Polymeric Micellar Solid Dispersion System to Domperidone for Improved Biopharmaceutical Characteristics”. Journal of Research in Pharmacy, vol. 27, no. 2, June 2025, pp. 860-72, https://izlik.org/JA77GX55SG.

Vancouver

1.Shimul Halder, M. A. K. Azad, Md. Shamiul Islam, Istiak Hossen, Lata Shuma, Eva Rahman Kabir. Strategic application of a mixed polymeric micellar solid dispersion system to domperidone for improved biopharmaceutical characteristics. J. Res. Pharm. [Internet]. 2025 Jun. 1;27(2):860-72. Available from: https://izlik.org/JA77GX55SG