Benzofuran fused phenyl pyrimidine/pyrazole schiff base derivatives as bioactive agents: anticancer, antimicrobial and molecular docking studies

Year 2022, Volume: 26 Issue: 5, 1432 - 1442, 28.06.2025

Sudarshana Shetty Rangaswamy Javarappa Nagaraja Naik

https://izlik.org/JA93SU86GK

Abstract

Benzofuran fused phenyl pyrimidine/pyrazole schiff base derivatives 8(a-e) and 9(a-e) have been
synthesized by a three step reaction. The structures of the synthesized compounds were established based on the
analytical and spectral data. The in-vitro anticancer and antimicrobial activity of compounds against MCF-7 and HeLa
cancer cell lines and microbes were studied. The compounds 8c and 9c showed significant levels of anticancer activity
compared to the standard. Molecular docking studies were performed on the active site of transferase (PDB ID: 4ANM)
with the synthesized ligands 8(a-e) and 9(a-e) for the optimization of the investigated compounds as potential cancer
cell inhibitors. The antimicrobial activity was performed by using well diffusion method, compounds 8d and 9d showed
maximum inhibition effect against the tested microbial pathogens, respectively.

Keywords

Benzofuran fused , pyrimidine , pyrazole , anticancer , antimicrobial , molecular docking

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