Acetylcholinesterase inhibitory activities and LC-MS analysis of the antioxidant Ferula caspica M. Bieb. and F. halophila Peşmen extracts

Çiğdem Kahraman; İpek Baysal; İffet İrem Tatlı Çankaya; Fatih Göğer; Neşe Kırımer; Zeliha Ş. Akdemir

Acetylcholinesterase inhibitory activities and LC-MS analysis of the antioxidant Ferula caspica M. Bieb. and F. halophila Peşmen extracts

Abstract

The aim of the current study is to evaluate the biological activity of F. caspica M. Bieb. which is used for the treatment of diabetes in traditional Turkish medicine and to compare with F. halophila Peşmen. Antioxidant capacities and total phenolic contents of the plants’ extracts were tested by DPPH radical scavenging assay and Folin Ciocalteu assay, respectively. Acetylcholinesterase inhibitory activities of the extracts were investigated with the aim of indicating whether there was a correlation with their antioxidant capacities. Different quinic acid and flavonoid derivatives which may be responsible for the activities of the extracts were detected using LC-MS screening in the methanol extracts. The methanol extract from the aerial parts of F. caspica was found to show most antioxidant capacity and acetylcholinesterase inhibitory activity.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacognosy

Journal Section

Research Article

Authors

Çiğdem Kahraman ^*
Türkiye

İpek Baysal This is me
Türkiye

İffet İrem Tatlı Çankaya
Türkiye

Fatih Göğer
Türkiye

Neşe Kırımer
Türkiye

Zeliha Ş. Akdemir This is me
Türkiye

Publication Date

June 27, 2025

Submission Date

September 27, 2018

Acceptance Date

December 22, 2018

Published in Issue

Year 2019 Volume: 23 Number: 3

IZ

https://izlik.org/JA98WL63DH

Cite

RIS / Bibtex

APA

Kahraman, Ç., Baysal, İ., Tatlı Çankaya, İ. İ., Göğer, F., Kırımer, N., & Akdemir, Z. Ş. (2025). Acetylcholinesterase inhibitory activities and LC-MS analysis of the antioxidant Ferula caspica M. Bieb. and F. halophila Peşmen extracts. Journal of Research in Pharmacy, 23(3), 543-551. https://izlik.org/JA98WL63DH

AMA

1.Kahraman Ç, Baysal İ, Tatlı Çankaya İİ, Göğer F, Kırımer N, Akdemir ZŞ. Acetylcholinesterase inhibitory activities and LC-MS analysis of the antioxidant Ferula caspica M. Bieb. and F. halophila Peşmen extracts. J. Res. Pharm. 2025;23(3):543-551. https://izlik.org/JA98WL63DH

Chicago

Kahraman, Çiğdem, İpek Baysal, İffet İrem Tatlı Çankaya, Fatih Göğer, Neşe Kırımer, and Zeliha Ş. Akdemir. 2025. “Acetylcholinesterase Inhibitory Activities and LC-MS Analysis of the Antioxidant Ferula Caspica M. Bieb. and F. Halophila Peşmen Extracts”. Journal of Research in Pharmacy 23 (3): 543-51. https://izlik.org/JA98WL63DH.

EndNote

Kahraman Ç, Baysal İ, Tatlı Çankaya İİ, Göğer F, Kırımer N, Akdemir ZŞ (June 1, 2025) Acetylcholinesterase inhibitory activities and LC-MS analysis of the antioxidant Ferula caspica M. Bieb. and F. halophila Peşmen extracts. Journal of Research in Pharmacy 23 3 543–551.

IEEE

[1]Ç. Kahraman, İ. Baysal, İ. İ. Tatlı Çankaya, F. Göğer, N. Kırımer, and Z. Ş. Akdemir, “Acetylcholinesterase inhibitory activities and LC-MS analysis of the antioxidant Ferula caspica M. Bieb. and F. halophila Peşmen extracts”, J. Res. Pharm., vol. 23, no. 3, pp. 543–551, June 2025, [Online]. Available: https://izlik.org/JA98WL63DH

ISNAD

Kahraman, Çiğdem - Baysal, İpek - Tatlı Çankaya, İffet İrem - Göğer, Fatih - Kırımer, Neşe - Akdemir, Zeliha Ş. “Acetylcholinesterase Inhibitory Activities and LC-MS Analysis of the Antioxidant Ferula Caspica M. Bieb. and F. Halophila Peşmen Extracts”. Journal of Research in Pharmacy 23/3 (June 1, 2025): 543-551. https://izlik.org/JA98WL63DH.

JAMA

1.Kahraman Ç, Baysal İ, Tatlı Çankaya İİ, Göğer F, Kırımer N, Akdemir ZŞ. Acetylcholinesterase inhibitory activities and LC-MS analysis of the antioxidant Ferula caspica M. Bieb. and F. halophila Peşmen extracts. J. Res. Pharm. 2025;23:543–551.

MLA

Kahraman, Çiğdem, et al. “Acetylcholinesterase Inhibitory Activities and LC-MS Analysis of the Antioxidant Ferula Caspica M. Bieb. and F. Halophila Peşmen Extracts”. Journal of Research in Pharmacy, vol. 23, no. 3, June 2025, pp. 543-51, https://izlik.org/JA98WL63DH.

Vancouver

1.Çiğdem Kahraman, İpek Baysal, İffet İrem Tatlı Çankaya, Fatih Göğer, Neşe Kırımer, Zeliha Ş. Akdemir. Acetylcholinesterase inhibitory activities and LC-MS analysis of the antioxidant Ferula caspica M. Bieb. and F. halophila Peşmen extracts. J. Res. Pharm. [Internet]. 2025 Jun. 1;23(3):543-51. Available from: https://izlik.org/JA98WL63DH