Synthesis of novel pyrazoline derivatives and evaluation of their antimicrobial activity

Fatih Tok; Muhammed Oğuzhan Doğan; Burçak Gürbüz; Bedia Kaymakçıoğlu

Synthesis of novel pyrazoline derivatives and evaluation of their antimicrobial activity

Abstract

In this study, new nine pyrazoline derivatives were synthesized from chalcone derivatives. The antimicrobial activity of nine pyrazoline derivatives to four standard bacterial strains (Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecalis) and four standard yeast strains (Candida albicans, Candida glabrata, Candida parapsilosis, Candida tropicalis) was investigated by the microdilution method for in accordance with the Clinical and Laboratory Standards Institute (CLSI) standard, and the Minimal Inhibitory Concentration (MIC) values of these derivatives were determined. Among these derivatives; compounds 7 and 8 against bacterial strains and compounds 2 and 3 against yeast strains exhibited good antimicrobial activity.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Chemistry, Pharmaceutical Microbiology

Journal Section

Research Article

Authors

Fatih Tok ^*
0000-0002-4569-008X
Türkiye

Muhammed Oğuzhan Doğan This is me
0000-0002-3911-6858
Türkiye

Burçak Gürbüz
0000-0002-1002-8264
Türkiye

Bedia Kaymakçıoğlu
0000-0003-0817-8236
Türkiye

Publication Date

June 28, 2025

Submission Date

June 23, 2022

Acceptance Date

July 19, 2022

Published in Issue

Year 2022 Volume: 26 Number: 5

IZ

https://izlik.org/JA23TR78UH

Cite

RIS / Bibtex

APA

Tok, F., Doğan, M. O., Gürbüz, B., & Kaymakçıoğlu, B. (2025). Synthesis of novel pyrazoline derivatives and evaluation of their antimicrobial activity. Journal of Research in Pharmacy, 26(5), 1453-1460. https://izlik.org/JA23TR78UH

AMA

1.Tok F, Doğan MO, Gürbüz B, Kaymakçıoğlu B. Synthesis of novel pyrazoline derivatives and evaluation of their antimicrobial activity. J. Res. Pharm. 2025;26(5):1453-1460. https://izlik.org/JA23TR78UH

Chicago

Tok, Fatih, Muhammed Oğuzhan Doğan, Burçak Gürbüz, and Bedia Kaymakçıoğlu. 2025. “Synthesis of Novel Pyrazoline Derivatives and Evaluation of Their Antimicrobial Activity”. Journal of Research in Pharmacy 26 (5): 1453-60. https://izlik.org/JA23TR78UH.

EndNote

Tok F, Doğan MO, Gürbüz B, Kaymakçıoğlu B (June 1, 2025) Synthesis of novel pyrazoline derivatives and evaluation of their antimicrobial activity. Journal of Research in Pharmacy 26 5 1453–1460.

IEEE

[1]F. Tok, M. O. Doğan, B. Gürbüz, and B. Kaymakçıoğlu, “Synthesis of novel pyrazoline derivatives and evaluation of their antimicrobial activity”, J. Res. Pharm., vol. 26, no. 5, pp. 1453–1460, June 2025, [Online]. Available: https://izlik.org/JA23TR78UH

ISNAD

Tok, Fatih - Doğan, Muhammed Oğuzhan - Gürbüz, Burçak - Kaymakçıoğlu, Bedia. “Synthesis of Novel Pyrazoline Derivatives and Evaluation of Their Antimicrobial Activity”. Journal of Research in Pharmacy 26/5 (June 1, 2025): 1453-1460. https://izlik.org/JA23TR78UH.

JAMA

1.Tok F, Doğan MO, Gürbüz B, Kaymakçıoğlu B. Synthesis of novel pyrazoline derivatives and evaluation of their antimicrobial activity. J. Res. Pharm. 2025;26:1453–1460.

MLA

Tok, Fatih, et al. “Synthesis of Novel Pyrazoline Derivatives and Evaluation of Their Antimicrobial Activity”. Journal of Research in Pharmacy, vol. 26, no. 5, June 2025, pp. 1453-60, https://izlik.org/JA23TR78UH.

Vancouver

1.Fatih Tok, Muhammed Oğuzhan Doğan, Burçak Gürbüz, Bedia Kaymakçıoğlu. Synthesis of novel pyrazoline derivatives and evaluation of their antimicrobial activity. J. Res. Pharm. [Internet]. 2025 Jun. 1;26(5):1453-60. Available from: https://izlik.org/JA23TR78UH