Encapsulation of paclitaxel in electrosprayed chitosan nanoparticles

Yücel Başpınar; Hasan Akbaba; Oguz Bayraktar

Encapsulation of paclitaxel in electrosprayed chitosan nanoparticles

Abstract

Paclitaxel is an anti-cancer drug, used to treat ovarian, breast and non-small-cell lung cancer among others. The low aqueous solubility of paclitaxel is a limiting factor for its application. Thus, paclitaxel is solubilized with help of surfactants and co-solvents, approved as Taxol®. Unfortunately, serious side effects like life-threatening hypersensitivity reactions and hemo-toxicity are limiting its use. Due to this, alternative formulations of paclitaxel are required. Nanoparticles represent an important approach to improve the poor solubility of drugs. In that context, electrospray for the preparation of nanoparticles is a promising approach. Due to these facts it was aimed in this study to develop and characterize paclitaxel loaded zein nanoparticles with and without the addition of chitosan. For that purpose the influence of the preparation parameters like the applied voltage and the flow rate on the characteristic properties of the particles were investigated step by step. The nanoparticles were characterized by investigating their particle size, size distribution, zeta potential, shapes and morphologies with help of dynamic light scattering, encapsulation efficiencies and AFM images, respectively. It was succeeded to prepare paclitaxel loaded zein nanoparticles without chitosan at a voltage of 22.5 kV and a flow rate of 0.2 ml/h having a particle size of 231 nm and an encapsulation effciency of 89%, while the paclitaxel loaded zein nanoparticles with chitosan had a particle size of 339 nm and an encapsulation effciency of 94%, prepared with 22.5 kV and a flow rate of 0.3 ml/h.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Biotechnology, Pharmaceutical Chemistry

Journal Section

Research Article

Authors

Yücel Başpınar ^*
Türkiye

Hasan Akbaba
Türkiye

Oguz Bayraktar
Türkiye

Publication Date

June 27, 2025

Submission Date

April 16, 2019

Acceptance Date

August 15, 2019

Published in Issue

Year 2019 Volume: 23 Number: 5

IZ

https://izlik.org/JA76RE83RH

Cite

RIS / Bibtex

APA

Başpınar, Y., Akbaba, H., & Bayraktar, O. (2025). Encapsulation of paclitaxel in electrosprayed chitosan nanoparticles. Journal of Research in Pharmacy, 23(5), 886-896. https://izlik.org/JA76RE83RH

AMA

1.Başpınar Y, Akbaba H, Bayraktar O. Encapsulation of paclitaxel in electrosprayed chitosan nanoparticles. J. Res. Pharm. 2025;23(5):886-896. https://izlik.org/JA76RE83RH

Chicago

Başpınar, Yücel, Hasan Akbaba, and Oguz Bayraktar. 2025. “Encapsulation of Paclitaxel in Electrosprayed Chitosan Nanoparticles”. Journal of Research in Pharmacy 23 (5): 886-96. https://izlik.org/JA76RE83RH.

EndNote

Başpınar Y, Akbaba H, Bayraktar O (July 1, 2025) Encapsulation of paclitaxel in electrosprayed chitosan nanoparticles. Journal of Research in Pharmacy 23 5 886–896.

IEEE

[1]Y. Başpınar, H. Akbaba, and O. Bayraktar, “Encapsulation of paclitaxel in electrosprayed chitosan nanoparticles”, J. Res. Pharm., vol. 23, no. 5, pp. 886–896, July 2025, [Online]. Available: https://izlik.org/JA76RE83RH

ISNAD

Başpınar, Yücel - Akbaba, Hasan - Bayraktar, Oguz. “Encapsulation of Paclitaxel in Electrosprayed Chitosan Nanoparticles”. Journal of Research in Pharmacy 23/5 (July 1, 2025): 886-896. https://izlik.org/JA76RE83RH.

JAMA

1.Başpınar Y, Akbaba H, Bayraktar O. Encapsulation of paclitaxel in electrosprayed chitosan nanoparticles. J. Res. Pharm. 2025;23:886–896.

MLA

Başpınar, Yücel, et al. “Encapsulation of Paclitaxel in Electrosprayed Chitosan Nanoparticles”. Journal of Research in Pharmacy, vol. 23, no. 5, July 2025, pp. 886-9, https://izlik.org/JA76RE83RH.

Vancouver

1.Yücel Başpınar, Hasan Akbaba, Oguz Bayraktar. Encapsulation of paclitaxel in electrosprayed chitosan nanoparticles. J. Res. Pharm. [Internet]. 2025 Jul. 1;23(5):886-9. Available from: https://izlik.org/JA76RE83RH